Exertional sickling: Questions and controversy

Sickle cell trait (SCT) occurs in about 8% of African-Americans and is often described to be of little clinical consequence. Over time, a number of risks have emerged, and among these are rare but catastrophic episodes of sudden death in athletes and other individuals associated with physical activities which is often described as exercise collapse associated with sickle trait (ECAST). Despite an epidemiologic link between SCT and sudden death as well as numerous case reports in both medical literature and lay press, no clear understanding of the key pathophysiologic events has been identified. Strategies for identification of individuals at risk and prevention of ECAST have been both elusive and controversial. Stakeholders have advocated for different approaches to this issue particularly with regard to screening for hemoglobin S. Furthermore, the recommendations and guidelines that are in place for the early recognition of ECAST and the prevention and treatment of the illness are not well defined and remain fragmented. Among the cases identified, those in collegiate football players in the United States are often highlighted. This manuscript examines these case studies and the current recommendations to identify areas of consensus and controversy regarding recommendations for prevention, recognition and treatment of ECAST

The Effects of Inter-particle Attractions on Colloidal Sedimentation

We use a mesoscopic simulation technique to study the effect of short-ranged inter-particle attraction on the steady-state sedimentation of colloidal suspensions. Attractions increase the average sedimentation velocity $v_s$ compared to the pure hard-sphere case, and for strong enough attractions, a non-monotonic dependence on the packing fraction $\phi$ with a maximum velocity at intermediate $\phi$ is observed. Attractions also strongly enhance hydrodynamic velocity fluctuations, which show a pronounced maximum size as a function of $\phi$. These results are linked to a complex interplay between hydrodynamics and the formation and break-up of transient many-particle clusters.Comment: 4 pages 4 figure

Direct numerical simulations for non-Newtonian rheology of concentrated particle dispersions

The non-Newtonian behavior of a monodisperse concentrated dispersion of spherical particles was investigated using a direct numerical simulation method, that takes into account hydrodynamic interactions and thermal fluctuations accurately. Simulations were performed under steady shear flow with periodic boundary conditions in the three directions. The apparent shear viscosity of the dispersions was calculated at volume fractions ranging from 0.31 to 0.56. Shear-thinning behavior was clearly observed at high volume fractions. The low- and high-limiting viscosities were then estimated from the apparent viscosity by fitting these data into a semi-empirical formula. Furthermore, the short-time motions were examined for Brownian particles fluctuating in concentrated dispersions, for which the fluid inertia plays an important role. The mean square displacement was monitored in the vorticity direction at several different Peclet numbers and volume fractions so that the particle diffusion coefficient is determined from the long-time behavior of the mean square displacement. Finally, the relationship between the non-Newtonian viscosity of the dispersions and the structural relaxation of the dispersed Brownian particles is examined

Multiplicity at the Stellar/Substellar Boundary in Upper Scorpius

We present the results of a high-resolution imaging survey of 12 brown dwarfs and very low mass stars in the closest (~145 pc) young (~5 Myr) OB association, Upper Scorpius. We obtained images with the Advanced Camera for Surveys/High Resolution Camera on HST through the F555W (V), F775W (i'), and F850LP (z') filters. This survey discovered three new binary systems, including one marginally resolved pair with a projected separation of only 4.9 AU, resulting in an observed binary fraction of 25+/-14% at separations >4 AU. After correcting for detection biases assuming a uniform distribution of mass ratios for q>0.6, the estimated binary fraction is 33+/-17%. The binary fraction is consistent with that inferred for higher-mass stars in Upper Sco, but the separation and mass ratio distributions appear to be different. All three low-mass binary systems in Upper Sco are tight (<18 AU) and of similar mass (q>0.6), consistent with expectations based on previous multiplicity studies of brown dwarfs and very low mass stars in the field and in open clusters. The implication is that the distinct separation and mass ratio distributions of low-mass systems are set in the formation process or at very young ages, rather than by dynamical disruption of wide systems at ages >5 Myr. Finally, we combine the survey detection limits with the models of Burrows et al. (1997) to show that there are no planets or very low-mass brown dwarfs with masses >10 M_J at projected separations >20 AU, or masses >5 M_J at projected separations >40 AU orbiting any of the low-mass (0.04-0.10 M_sun) objects in our sample.Comment: Accepted for publication in ApJ; 10 pages, 4 figures in emulateapj forma

Studies in physiological undernourishment in sheep

1. An examination of changes in weight and body composition in a flock of free -grazing Scottish Blackface ewes indicated that, during the greater part of pregnancy, these ewes were undernourished and catabolizing considerable amounts of body tissue.2. The nutritional states of ewes from two differently managed Scottish Blackface flocks were characterized during late pregnancy in terms of circulating concentrations of plasma free fatty acids and ketones. Marked undernourishment was evident in both situations.3. Data collected in a variety of situations supported the hypothesis that the severity of undernourishment during late pregnancy is determined principally by foetal weight and the level of food intake. Within a group of pregnant ewes with comparable intakes, the general degree of undernourishment is dependent on the level of intake, and the relative severity of undernourishment in individual animals is determined by differences in foetal weight.4. The use of certain biochemical parameters as indices of undernourishment was examined in ewes with artificially induced hypoglycaemia. It was concluded that nutritional state is best characterized in terms of that parameter which shows the greatest response per unit change in either nutrient intake or nutrient requirement.5. Biochemical parameters were used to control the nutritional states of individual animals in an experiment on the effects of undernourishment during pregnancy on lamb birth- weight. The results of this experiment indicated that the undernourishment occurring in free- grazing hill ewes during late pregnancy was likely to reduce the birth - weight of single lambs by 10%, and that of twins by 25%.6. The additional energy requirements during pregnancy were estimated to be 100g digestible organic matter per kg foetus

Torts - Invasion of Privacy - Conduct of a Debt Collector

In an action for the balance due on account for merchandise purchased defendants counterclaimed for damages alleging that an agent of the plaintiff, on three separate days, went to the restaurant where the defendant-wife worked as a waitress and in a loud and degrading manner made demands that defendants pay the account. On each occasion many customers were present. Plaintiff\u27s agent accused the defendants of being dead beats and of never intending to pay for the merchandise when it was purchased. The trial court sustained plaintiff\u27s demurrer to this counterclaim. On appeal, held, reversed and remanded. Conduct of a debt collector which degrades and humiliates the debtor in public and which would be deemed offensive to persons of ordinary sensibilities gives rise to a cause of action for invasion of privacy. Biederman\u27s of Springfield v. Wright, (Mo. 1959) 322 S.W. (2d) 892

Phase Stability and Segregation in Alloy 22 Base Metal and Weldments

The current design of the waste disposal containers relies heavily on encasement in a multi-layered container, featuring a corrosion barrier of Alloy 22, a Ni-Cr-Mo-W based alloy with excellent corrosion resistance over a wide range of conditions. The fundamental concern from the perspective of the Yucca Mountain Project, however, is the inherent uncertainty in the (very) long-term stability of the base metal and welds. Should the properties of the selected materials change over the long service life of the waste packages, it is conceivable that the desired performance characteristics (such as corrosion reistance) will become compromised, leading to premature failure of the system. To address this, we will study the phase stability and solute segregation characteristics of Alloy 22 base metal and welds. A better understanding of the underlying microstructural evolution tendencies, and their connections with corrosion behavior will (in turn) produce a higher confidence in the extrapolated behavior of the container materials over time periods that are not feasibly tested in a laboratory. Additionally, the knowledge gained here may potentially lead to cost savings through development of safe and realistic design constraints and model assumptions throughout the entire disposal system

Correlated dynamics of inclusions in a supported membrane

The hydrodynamic theory of heterogeneous fluid membranes is extended to the case of a membrane adjacent to a solid substrate. We derive the coupling diffusion coefficients of pairs of membrane inclusions in the limit of large separation compared to the inclusion size. Two-dimensional compressive stresses in the membrane make the coupling coefficients decay asymptotically as $1/r^2$ with interparticle distance $r$. For the common case, where the distance to the substrate is of sub-micron scale, we present expressions for the coupling between distant disklike inclusions, which are valid for arbitrary inclusion size. We calculate the effect of inclusions on the response of the membrane and the associated corrections to the coupling diffusion coefficients to leading order in the concentration of inclusions. While at short distances the response is modified as if the membrane were a two-dimensional suspension, the large-distance response is not renormalized by the inclusions.Comment: 15 page