Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR/Cas9 gene editing technology

CAR-T cell therapy, a novel immunotherapy, has made significant breakthroughs in clinical practice, particularly in treating B-cell-associated leukemia and lymphoma. However, it still faces challenges such as poor persistence, limited proliferation capacity, high manufacturing costs, and suboptimal efficacy. CRISPR/Cas system, an efficient and simple method for precise gene editing, offers new possibilities for optimizing CAR-T cells. It can increase the function of CAR-T cells and reduce manufacturing costs. The combination of CRISPR/Cas9 technology and CAR-T cell therapy may promote the development of this therapy and provide more effective and personalized treatment for cancer patients. Meanwhile, the safety issues surrounding the application of this technology in CAR-T cells require further research and evaluation. Future research should focus on improving the accuracy and safety of CRISPR/Cas9 technology to facilitate the better development and application of CAR-T cell therapy. This review focuses on the application of CRISPR/Cas9 technology in CAR-T cell therapy, including eliminating the inhibitory effect of immune checkpoints, enhancing the ability of CAR-T cells to resist exhaustion, assisting in the construction of universal CAR-T cells, reducing the manufacturing costs of CAR-T cells, and the security problems faced. The objective is to show the revolutionary role of CRISPR/Cas9 technology in CAR-T cell therapy for researchers

Study on the Relation between the Mn/Al Mixed Oxides Composition and Performance of FCC Sulfur Transfer Agent

A sulfur transfer agent in catalysts can effectively reduce the emission of SO2 with minimum adverse effects on the catalytic cracking ability of the primary catalyst. In this paper, the composition and performance of sulfur transfer agents with different oxidative active components (such as Cu, Fe, Ni, Co, Ba, Zn and Cr) were prepared by acid peptization technique and characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and N2 adsorption-desorption technique. The relationship between the composition and performance of the new sulfur transfer agents was investigated and the regeneration and recycling of the agents were performed. The results indicates that copper is a very good desulfurization active component. Moreover, the presence of CO has no significant effect on the absorption ability of SO2 by the sulfur transfer agent

Synthesis and Applications of SAPO-34 Molecular Sieves

Silicoaluminophosphate zeolite (SAPO-34) has been attracting increasing attention due to its excellent form selection and controllability in the chemical industry, as well as being one of the best industrial catalysts for methanol-to-olefin (MTO) reaction conversion. However, as a microporous molecular sieve, SAPO-34 easily generates carbon deposition and rapidly becomes inactivated. Therefore, it is necessary to reduce the crystal size of the zeolite or to introduce secondary macropores into the zeolite crystal to form a hierarchical structure in order to improve the catalytic effect. In this review, the synthesis methods of conventional SAPO-34 molecular sieves, hierarchical SAPO-34 molecular sieves and nanosized SAPO-34 molecular sieves are introduced, and the properties of the synthesized SAPO-34 molecular sieves are described, including the phase, morphology, pore structure, acid source, and catalytic performance, in particular with respect to the synthesis of hierarchical SAPO-34 molecular sieves. We hope that the review can provide guidance to the preparation of the SAPO-34 catalysts, and stimulate the future development of high-performance hierarchical SAPO-34 catalysts to meet the growing demands of the material and chemical industries

Interfacial structure and photocatalytic degradation performance of graphene oxide bridged chitin-modified TiO2/carbon fiber composites

With the advancement of industrialization, developing efficient photocatalysts are needed to resolve the more serious water pollution problems. In this study, the chitin-modified and graphene oxide (GO) bridged TiO2/ carbon fibers (CGTC) were synthesized by a facile hydrothermal treatment. The CGTC80 (adding 80 mg GO) exhibited high adsorption and higher photodegradation ability than pure TiO2. The results shows that 50 ml of 50 mg L-1 RhB solution could be almost completely degraded (97%) in 60min. The racial trapping examination shows that the photogenerated holes (h+) is the may active species in the photocatalytic system. After 3 cycles degradation, the photocatalyst still has high photocatalytic performance (> 90%). Meanwhile, the high performance of CGTC for pollutants may due to the creation of more adsorption sites by dispersion of chitin and rapid conduction of electrons effected by GO. In general, this visible-light-driven chitin-modified graphene oxide bridged TiO2/CF catalyst exhibits significant potential in terms of stability and reproducibility for sewage treatment applications

Interfacial structure and photocatalytic degradation performance of graphene oxide bridged chitin-modified TiO2/carbon fiber composites

With the advancement of industrialization, developing efficient photocatalysts are needed to resolve the more serious water pollution problems. In this study, the chitin-modified and graphene oxide (GO) bridged TiO2/ carbon fibers (CGTC) were synthesized by a facile hydrothermal treatment. The CGTC80 (adding 80 mg GO) exhibited high adsorption and higher photodegradation ability than pure TiO2. The results shows that 50 ml of 50 mg L-1 RhB solution could be almost completely degraded (97%) in 60min. The racial trapping examination shows that the photogenerated holes (h+) is the may active species in the photocatalytic system. After 3 cycles degradation, the photocatalyst still has high photocatalytic performance (> 90%). Meanwhile, the high performance of CGTC for pollutants may due to the creation of more adsorption sites by dispersion of chitin and rapid conduction of electrons effected by GO. In general, this visible-light-driven chitin-modified graphene oxide bridged TiO2/CF catalyst exhibits significant potential in terms of stability and reproducibility for sewage treatment applications