Additional file 4 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 4: Table S3. Expression level changes of genes near integration site

Additional file 8 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 8: Table S7. Detailed pMEI annotations for GSH selection

Additional file 10 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 10. Review history

Additional file 3 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 3: Table S2. Differentially expressed genes in GFP integrated cell lines

Additional file 6 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 6: Table S5. Loss of GFP level based on integration sites

Additional file 7 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 7: Table S6. GFP flow cytometry data of day 1 and day 90 for WT and GFP inserted HUDEP2 clones

Additional file 1 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 1: Supplementary figures: Figure S1. Pipeline workflow for identification of GSH sites. Figure S2: Circos plot representation of GSH sites identified in blood (a) and brain (b) data. Figure S3: PCR validation of GFP inserted cell line. Figure S4: Genome wide gene expression Correlation between GFP integrated cell lines and HUDEP2 cells. Figure S5: Volcano plot representation of Differentially Expressed Genes for four GSH integration sites. Figure S6: GFP maintenance after one month based on different integration sites. Figure S7: GFP expression in Day 1 and Day 90 for 5 GFP clones of BLD_GSH_10. Figure S8: Flow cytometry of GFP and Band3 staining of HUDEP2 GFP clones and HUDEP2 WT cells on day 0 and day 4 of differentiation. Figure S9: Plasmid vector used for the GFP insertion in HUDEP2 cells

Additional file 5 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 5: Table S4. Alternative splicing events detected by rMATS

Additional file 2 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 2: Table S1. gRNA editing efficiency for different loci and primers used for validation of GFP integratio

Additional file 9 of Genomics and epigenetics guided identification of tissue-specific genomic safe harbors

Additional file 9: Table S8. Data used to define repressive and active chromatin regions