Additional file 1: Table S1. of Copy number variations in 119 Chinese children with idiopathic short stature identified by the custom genome-wide microarray

List of 1469 height-associated candidate genes analyzed by genome-wide association studies. Table S2. Summary of type III and IV CNVs. Table S3. Primers of qPCR. Figure S1. Screenshots of chromosome microarray and qPCR. (DOC 7216 kb

Functional impacts of <i>FTO</i> and <i>SH2B1</i> rare non-synonymous mutations.

<p>PROVEAN: Protein Variation Effect Analyzer; SIFT: Sorts Intolerant From Tolerant; Polyphen-2: Polymorphism Phenotyping v2.</p

The anthropological characteristics of children with early-onset obesity and lean control.

<p>Data are means±SD unless otherwise indicated.</p

Prevalence of rare non-synonymous mutations in <i>FTO</i> in obese and lean children.

<p>Rare non-synonymous mutations denote variations with frequency<0.01.</p

Distribution of rare non-synonymous variants along FTO functional domains.

<p>FTO protein is consisted of a N-terminal domain (NTD, residue 32–326) and a C-terminal domain (CTD, residue 327–505). Different non-synonymous mutations with frequency in parenthesis were presented both for obese children and control population.</p

Difference on prevalence of <i>FTO</i> rare non-synonymous mutation between boys and girls with obesity.

<p>Difference on prevalence of <i>FTO</i> rare non-synonymous mutation between boys and girls with obesity.</p

Prevalence of <i>FTO</i> and <i>SH2B1</i> rare non-synonymous mutations in different populations.

<p>ESP: NHLBI Exome Sequencing Project; CHC: Chinese Han children; FC/EC: French children/English children from Meyre's cohort <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067039#pone.0067039-Ren2" target="_blank">[22]</a>; EA: European American; AA: African American.</p