18 research outputs found
Regioselective Cycloaddition of Nitrile Imines to 5-Methylidene-3-phenyl-hydantoin: Synthesis and DFT Calculations
Nitrile imine cycloaddition to hydantoins containing an exocyclic C=C double bond has been previously described in a very limited number of examples. In this work, regioselective synthesis of spiro-pyrazoline-imidazolidine-2,4-diones based on a 1,3-dipolar cycloaddition reaction of nitrile imines to 5-methylidene-3-phenyl-hydantoin have been proposed. It was found that, regardless of the nature of the aryl substituents at the terminal C and N atoms of the C-N-N fragment of nitrile imine (electron donor or electron acceptor), cycloaddition to the 5-methylidenhydantoin exocyclic C=C bond proceeds regioselectively, and the terminal nitrogen atom of the nitrile imine connects to the more sterically hindered carbon atom of the double bond, which leads to the formation of a 5-disubstituted pyrazoline ring. The observed cycloaddition regioselectivity was rationalized using DFT calculations of frontier molecular orbital interactions, global CDFT reactivity indices, and minimum energy paths
The role of phosphate additive in stabilization of sulphuric-acid-based vanadium(V) electrolyte for all-vanadium redox-flow batteries
Catholyte in all-vanadium redox-flow battery (VRFB) which consists of vanadium salts dissolved in sulphuric acid is known to be stabilized by phosphoric acid to slow down the thermal aging at temperatures higher than 40 degrees C. To reveal the role of phosphoric acid, the thermally-induced aggregation is investigated using variable-temperature V-51, P-31, O-17, H-1 nuclear magnetic resonance (NMR) spectroscopy and dynamic light scattering (DLS). The results indicate that the thermal stabilization of vanadium(V) electrolyte is attained by the involvement of monomeric and dimeric vanadium(V) species in the reaction with phosphoric acid which is concurrent to the formation of neutral hydroxo-aqua vanadium(V) precipitation precursor. The dimers are stabilized by counter ions due to association reaction or if such stabilization is not possible, precipitation of vanadium pentoxide is favored. The evolution of particles size distributions at 50 degrees C in electrolyte samples containing 1.6 M vanadium and 4.0 M total sulphate and the pathways of precipitate formation are discussed. The optimal total phosphate concentration is found to be of 0.15 M. However, the induction time is assumed to be dependent not only on the total phosphate concentrations, but also on the ratio of total vanadium(V) to sulphate concentrations
First Example of Fluorinated Phenanthroline Diamides: Synthesis, Structural Study, and Complexation with Lanthanoids
An efficient approach to the synthesis of diamides of 4,7-difluoro-1,10-phenanthroline-2,9-dicarboxylic acid was elaborated. Direct nucleophilic substitution with 4,7-dichloro-1,10-phenanthroline precursors opened access to difluoro derivatives in high yield. As a result, four new fluorinated ligands were prepared in up to 88% yield. Their structure was proved by a combination of spectral methods and X-ray data. A set of lanthanoid complexes was prepared to demonstrate the utility of new ligands. The structure of the complexes was studied in solid state (IR-spectroscopy, X-ray diffraction) and in solution (NMR-spectroscopy)
Phenoxaphosphonium Mixed Ylides in Ring Expansion Reaction
Treatment of mixed phosphonium–iodonium
ylides featuring
a six-membered phenoxaphosphonium fragment with aqueous tetrafluoroboronic
acid induces a rearrangement, resulting in expansion of the phosphacycle
and oxidation of the phosphorus atom. The target difficult-to-access
dibenzo[b,f][1,4]oxaphosphepine
oxides (3 examples) were isolated in excellent yields (up to 95%)
as mixtures of stereoisomers. Hydrolysis of a five-membered mixed
ylide, a dibenzophosphole derivative, predominantly preserves the
phosphole system with cycle expansion occurring as a side process
Dispirooxindole-β-Lactams: Synthesis via Staudinger Ketene-Imine Cycloaddition and Biological Evaluation
In this work, we present the first synthesis of dispirooxindole-β-lactams employing optimized methodology of one-pot Staudinger ketene-imine cycloaddition with N-aryl-2-oxo-pyrrolidine-3-carboxylic acids as the ketene source. Spiroconjugation of indoline-2-one with β-lactams ring is considered to be able to provide stabilization and wide scope of functionalization to resulting scaffolds. The dispipooxindoles obtained demonstrated medium cytotoxicity in the MTT test on A549, MCF7, HEK293, and VA13 cell lines, and one of the compounds demonstrated antibacterial activity against E. coli strain LPTD
Phenoxaphosphonium Mixed Ylides in Ring Expansion Reaction
Treatment of mixed phosphonium–iodonium
ylides featuring
a six-membered phenoxaphosphonium fragment with aqueous tetrafluoroboronic
acid induces a rearrangement, resulting in expansion of the phosphacycle
and oxidation of the phosphorus atom. The target difficult-to-access
dibenzo[b,f][1,4]oxaphosphepine
oxides (3 examples) were isolated in excellent yields (up to 95%)
as mixtures of stereoisomers. Hydrolysis of a five-membered mixed
ylide, a dibenzophosphole derivative, predominantly preserves the
phosphole system with cycle expansion occurring as a side process
Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vector moiety and tripeptide linker with terminal amide and azide groups for subsequent addition of two different therapeutic and diagnostic agents. The optimal method for this molecular platform synthesis includes (a) solid-phase assembly of the polypeptide linker, (b) coupling of this linker with the vector fragment, (c) attachment of 3-aminopropylazide, and (d) amide and carboxylic groups deprotection. A bimodal theranostic conjugate of the proposed platform with a cytostatic drug (docetaxel) and a fluorescent label (Sulfo-Cy5) was synthesized to demonstrate its possible sequential conjugation with different functional molecules
When Applying the Mercury Poisoning Test to Palladacycle-Catalyzed Reactions, One Should Not Consider the Common Misconception of Mercury(0) Selectivity
The
aim of this study was to demonstrate the absolute necessity
of control experiments for a correct interpretation of mercury drop
test results when applied to mechanistic studies of palladacycle-catalyzed
reactions. It was shown that the interaction of diverse azapalladacycles
with metallic mercury leads to the formation of organomercuric chlorides
during the redox-transmetalation process. The structure of these organomercurials
was confirmed by elemental analysis, <sup>1</sup>H, <sup>13</sup>CÂ{<sup>1</sup>H}, and <sup>199</sup>HgÂ{<sup>1</sup>H} NMR spectra, X-ray
diffraction analysis, and DFT calculations. The behavior and properties
of <i>C</i>,<i>N</i>-mercuracycles bearing the
weak and labile N···Hg bond are discussed on the basis
of the temperature dependence of the NMR spectra and calculated thermodynamic
parameters of the dechelation process