Macroeconomia, Habitação e Desenvolvimento Regional:: o Complexo Multimodal Aluízio Campos em Campina Grande-PB

Um dos desafios das políticas públicas no Brasil é gerir o processo habitacional dentro de um contexto de uma urbanização acelerada. Campina Grande passou a enfrentar essa conjuntura com os condomínios populares, projetados pelo extinto Banco Nacional de Habitação (BNH) e, posteriormente, pelo Programa Minha Casa, Minha Vida (PMCMV). O objetivo deste artigo é analisar a fase inicial da implantação do conjunto habitacional localizado no interior do Complexo Multimodal Aluízio Campos (CMAC), com 4.100 unidades habitacionais, em Campina Grande-PB. A pesquisa ancorou-se no plano-projeto do Complexo com suas informações básicas e também pesquisa etnográfica com visitação in loco, coleta de registros fotográficos e entrevistas semiestruturadas com gestores do projeto e indivíduos sorteados com as residências

In-Vitro Subtype-Specific Modulation of HIV-1 Trans-Activator of Transcription (Tat) on RNAi Silencing Suppressor Activity and Cell Death

Human immunodeficiency virus (HIV) is a global health concern affecting millions of individuals with a wide variety of currently circulating subtypes affecting various regions of the globe. HIV relies on multiple regulatory proteins to modify the host cell to promote replication in infected T cells, and these regulatory proteins can have subtle phenotypic differences between subtypes. One of these proteins, HIV-1 Trans-Activator of Transcription (Tat), is capable of RNA interference (RNAi) Silencing Suppressor (RSS) activity and induction of cell death in T cells. However, the subtype-specific RSS activity and induction of cell death have not been explored. We investigated the ability of Tat subtypes and variants to induce RSS activity and cell death. TatB, from HIV-1 subtype B, was found to be a potent RSS activator by 40% whereas TatC, from HIV-1 subtype C, showed 15% RSS activity while subtype TatC variants exhibited varying levels. A high level of cell death (50–53%) was induced by subtype TatB when compared to subtype TatC (25–28%) and varying levels were observed with subtype TatC variants. These differential activities could be due to variations in the functional domains of Tat. These observations further our understanding of subtype-specific augmentation of Tat in HIV-1 replication and pathogenesis

Des stratégies de lutte contre le paludisme à Kinshasa. Cas du quartier Kikimi dans la commune de Kimbanseke. Essai d’analyse sociologique

La lutte contre le paludisme ne constitue pas une nouvelle préoccupation dans le champ des investigations scientifiques. Plusieurs études ont été menées à ce sujet. Quant à la présente recherche, la préoccupation essentielle porte sur les stratégies mises en place et pour ce faire, apprécier le niveau d’appropriation des mécanismes de lutte contre la malaria par les Kinois, au niveau de leurs entités locales