3,983 research outputs found
Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss.
The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified using this method misses a substantial percentage of extant neurons in a phenotype specific manner. In mice, 24% more hypocretin/orexin (Hcrt) neurons are seen in the night compared to the day, and an additional 17% are seen after inhibiting microtubule polymerization with colchicine. We see no such difference between the number of MCH (melanin concentrating hormone) neurons in dark, light or colchicine conditions, despite MCH and Hcrt both being hypothalamic peptide transmitters. Although the size of Hcrt neurons did not differ between light and dark, the size of MCH neurons was increased by 15% in the light phase. The number of neurons containing histidine decarboxylase (HDC), the histamine synthesizing enzyme, was 34% greater in the dark than in the light, but, like Hcrt, cell size did not differ. We did not find a significant difference in the number or the size of neurons expressing choline acetyltransferase (ChAT), the acetylcholine synthesizing enzyme, in the horizontal diagonal band (HBD) during the dark and light conditions. As expected, colchicine treatment did not increase the number of these neurons. Understanding the function and dynamics of transmitter production within "non-visible" phenotypically defined cells has fundamental implications for our understanding of brain plasticity
Pressure-Induced Anomalous Phase Transitions and Colossal Enhancement of Piezoelectricity in PbTiO
We find an unexpected tetragonal-to-monoclinic-to-rhombohedral-to-cubic phase
transition sequence induced by pressure, and a morphotropic phase boundary in a
pure compound using first-principles calculations. Huge dielectric and
piezoelectric coupling constants occur in the transition regions, comparable to
those observed in the new complex single-crystal solid-solution piezoelectrics
such as Pb(MgNb)O-PbTiO, which are expected to
revolutionize electromechanical applications. Our results show that
morphotropic phase boundaries and giant piezoelectric effects do not require
intrinsic disorder, and open the possibility of studying this effect in simple
systems.Comment: 4 pages, to appear in Phys. Rev. Let
Quaking Aspen Reproduce From Seed After Wildfire in the Mountains of Southeastern Arizona
Quaking aspen regenerated from seed after a stand replacement wildfire in the Chiricahua Mountains of southeastern Arizona. The wildfire had created gaps in the canopy so that aspen were able to establish from seed. Seedlings were found at a mean density of 0.17 m–2, 30 m or more from the nearest potential seed trees. Six clumps of aspen seedlings contained 18–186 trees, occupying areas of 145–500 square meters at densities of 0.09-0.27 m–2. White-tailed deer (Odocoileus virginianus) browsed 14.3% of the seedlings. Occasional sexual reproduction of aspen may be a general trait of the species throughout the western portion of its range in North America
Individual differences in infant fixation duration relate to attention and behavioral control in childhood
Individual differences in fixation duration are considered a reliable measure of attentional control in adults. However, the degree to which individual differences in fixation duration in infancy (0–12 months) relate to temperament and behavior in childhood is largely unknown. In the present study, data were examined from 120 infants (mean age = 7.69 months, SD = 1.90) who previously participated in an eye-tracking study. At follow-up, parents completed age-appropriate questionnaires about their child’s temperament and behavior (mean age of children = 41.59 months, SD = 9.83). Mean fixation duration in infancy was positively associated with effortful control (β = 0.20, R2 = .02, p = .04) and negatively with surgency (β = −0.37, R2 = .07, p = .003) and hyperactivity-inattention (β = −0.35, R2 = .06, p = .005) in childhood. These findings suggest that individual differences in mean fixation duration in infancy are linked to attentional and behavioral control in childhood
Weakly-Supervised 3D Reconstruction of Clothed Humans via Normal Maps
We present a novel deep learning-based approach to the 3D reconstruction of
clothed humans using weak supervision via 2D normal maps. Given a single RGB
image or multiview images, our network infers a signed distance function (SDF)
discretized on a tetrahedral mesh surrounding the body in a rest pose.
Subsequently, inferred pose and camera parameters are used to generate a normal
map from the SDF. A key aspect of our approach is the use of Marching
Tetrahedra to (uniquely) compute a triangulated surface from the SDF on the
tetrahedral mesh, facilitating straightforward differentiation (and thus
backpropagation). Thus, given only ground truth normal maps (with no volumetric
information ground truth information), we can train the network to produce SDF
values from corresponding RGB images. Optionally, an additional multiview loss
leads to improved results. We demonstrate the efficacy of our approach for both
network inference and 3D reconstruction
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