Low loss, high contrast optical waveguides based on CMOS compatible LPCVD processing

A new class of integrated optical waveguide structures is presented, based on low cost CMOS compatible LPCVD processing. This technology allows for medium and high index contrast waveguides with very low channel attenuation. The geometry is basically formed by a rectangular cross-section silicon nitride $(Si_{3}N_{4})$ filled with and encapsulated by silicon dioxide $(SiO_{2})$. The birefringence and minimal bend radius of the waveguide is completely controlled by the geometry of the waveguide layer structures. Experiments on typical geometries will be presented, showing excellent characteristics (channel attenuation ≤0.06 dB/cm, IL ≤0.6 dB, PDL ≤0.2 dB, Bg «1 x $10^{-3}$, bend radius ≤500 μm)

Integrated optical beamformers

This paper discusses the challenges towards the realization of the integrated microwave photonic beamformer based on hybrid integration between InP and TriPleX Si3N4/SiO2

A compact and reconfigurable silicon nitride time-bin entanglement circuit

Photonic chip based time-bin entanglement has attracted significant attention because of its potential for quantum communication and computation. Useful time-bin entanglement systems must be able to generate, manipulate and analyze entangled photons on a photonic chip for stable, scalable and reconfigurable operation. Here we report the first time-bin entanglement photonic chip that integrates time-bin generation, wavelength demultiplexing and entanglement analysis. A two-photon interference fringe with an 88.4% visibility is measured (without subtracting any noise), indicating the high performance of the chip. Our approach, based on a silicon nitride photonic circuit, which combines the low-loss characteristic of silica and tight integration features of silicon, paves the way for scalable real-world quantum information processors.Comment: 4 pages, 5 figure

A real-life cohort study of immunoglobulin light-chain (AL) amyloidosis patients ineligible for autologous stem cell transplantation due to severe cardiac involvement or advanced disease

Objective: To study the outcome of patients with AL amyloidosis who were ineligible for high dose melphalan (HDM) and autologous stem cell transplantation (ASCT).Methods: A real-life retrospective observational cohort study of Dutch patients with AL amyloidosis ineligible for HDM and ASCT was performed at the University Medical Center Groningen from January 2001 until April 2017. Primary outcome measure was overall survival (OS). Secondary outcome measures were hematological response (HR), organ responses, and treatment toxicity.Results: Eighty-four patients were included. Ineligibility was due to NYHA class III/IV (n = 58), otherwise advanced disease (n = 11), advanced age (n = 14), or treatment refusal (n = 1). Early death (<3 months) rate was high (44%). Median OS improved from 4 months in period 2001-2009 (n = 36) to 8 months in period 2009-2017 (n = 48, p = .02). HR was seen in 29%, and 42% of the patients, respectively. Median OS was 36 months after induction treatment with bortezomib (n = 32) and 18 months with immunomodulatory imide drug (IMID) (n = 16), both higher than median OS (7 months) with other regimens (n = 27). Incidence of toxicity was high (51%).Conclusion: OS improved in this high-risk group over the years, especially after introduction of new treatment modalities. However, early death rate remains high, illustrating the need for more effective treatment

Optically switched 56 GBd PAM-4 using a hybrid InP-TriPleX integrated tunable laser based on silicon nitride micro-ring resonators

Tunable lasers are key elements for switching fabrics in future datacenter networks. Experimental results show transmission of 56 GBd PAM-4 data in a switching environment using an integrated silicon nitride micro-ring resonator based tunable laser

Advancement of photonic integration technology for space applications: A x-band scan-on-receive synthetic aperture radar receiver with electro-photonic beamforming and frequency downconversion capability

Synthetic Aperture Radar is a well-known technique for remote sensing applications with great advantages like uninterrupted imaging capabilities even at night or in presence of cloud cover. However, spaceborne SAR sensors face major challenges such as cost and size, which are among the barriers against their applicability for future constellations of low-Earth observation applications. SAR sensors are not compact and require large or medium-sized satellites, which cost hundreds million dollars. To solve these challenges, the recently started SPACEBEAM project, funded by the European Commission, aims at developing a novel SAR Scan-on-Receive approach, exploiting a hybrid integrated optical beamforming network (iOBFN). The compactness and frequency flexibility of the proposed photonic solution complies with the requirements of future constellations of low-Earth orbit satellites in terms of size, weight, power consumption, and cost (SWaP-C). In the design of the SCORE SAR receiver module, we target the development of an X-band receiver having a large swath width of 50 km (5 times wider than state-of-art spaceborne SAR systems), although at the same time enabling a fine spatial resolution of 1.5 m in both along-track and across-track directions. In this paper, we present specifications and preliminary design of the SCORE-SAR receiver at equipment level, where we aim at the realization of a hermetically packaged hybrid InP/TriPleX™ photonic integrated circuit (PIC) for this application. We target the design for the PIC as well as for the RF front-end and control electronics, enabling the electro-photonic frequency down-conversion of the RF signals and the fast control of iOBFN with &lt;300 ns switching time

Design and Performance Estimation of a Photonic Integrated Beamforming Receiver for Scan-On-Receive Synthetic Aperture Radar

Synthetic aperture radar is a remote sensing technology finding applications in a wide range of fields, especially related to Earth observation. It enables a fine imaging that is crucial in critical activities, like environmental monitoring for natural resource management or disasters prevention. In this picture, the scan-on-receive paradigm allows for enhanced imaging capabilities thanks to wide swath observations at finer azimuthal resolution achieved by beamforming of multiple simultaneous antenna beams. Recently, solutions based on microwave photonics techniques demonstrated the possibility of an efficient implementation of beamforming, overcoming some limitations posed by purely electronic solutions, offering unprecedented flexibility and precision to RF systems. Moreover, photonics-assisted RF beamformers can nowadays be realized as integrated circuits, with reduced size and power consumption with respect to digital beamforming approaches. This paper presents the design analysis and the challenges of the development of a hybrid photonic-integrated circuit as the core element of an X-band scan-on-receive spaceborne synthetic aperture radar. The proposed photonic-integrated circuit synthetizes three simultaneous scanning beams on the received signal, and performs the frequency down-conversion, guaranteeing a compact 15 cm2-form factor, less than 6 W power consumption, and 55 dB of dynamic range. The whole photonics-assisted system is designed for space compliance and meets the target application requirements, representing a step forward toward a deeper penetration of photonics in microwave applications for challenging scenarios, like the observation of the Earth from space

Neurofilament light chain, a biomarker for polyneuropathy in systemic amyloidosis

OBJECTIVE: To study serum neurofilament light chain (sNfL) in amyloid light chain (AL) amyloidosis patients with and without polyneuropathy (PNP) and to corroborate previous observations that sNfL is increased in hereditary transthyretin-related (ATTRv) amyloidosis patients with PNP. METHODS: sNfL levels were assessed retrospectively in patients with AL amyloidosis with and without PNP (AL/PNP+ and AL/PNP-, respectively), patients with ATTRv amyloidosis and PNP (ATTRv/PNP+), asymptomatic transthyretin (TTR) gene mutation carriers (TTRv carriers) and healthy controls. Healthy controls (HC) were age- and sex-matched to both AL/PNP- (HC/AL) and TTRv carriers (HC/TTRv). The single-molecule array (Simoa) assay was used to assess sNfL levels. RESULTS: sNfL levels were increased both in 10 AL/PNP+ patients (p  I) had the highest sNfL levels compared to patients with early PNP (PND-score I) (p = .05). sNfL levels did not differ between TTRv carriers and HC/TTRv individuals. In the group comprising all healthy controls and in the group of TTRv carriers, sNfL levels correlated with age. CONCLUSION: sNfL levels are increased in patients with PNP in both AL and ATTRv amyloidosis and are related to severity of PNP in ATTRv amyloidosis. sNfL is a promising biomarker to detect PNP, not only in ATTRv but also in AL amyloidosis