An Evaluation into Pilot Proficiency Assessment and the Current State of Training in the Industry

Pilot proficiency assessment has been a debated topic, especially in recent years. Determining effective ways to assess proficiency has been the focus of many industries, including similar high-risk industries such as health care and nuclear power industries. For the purposes of this paper, a comprehensive investigation into the current state of pilot training was conducted to analyze and compare curriculum components, proficiency levels, assessment methods and overall safety outcomes of each instructional program. This analysis includes pilot training programs from the United States, Australia and the European Union, as they relate to pilot licensing. As flight training technology and hour requirements increase, alternate methods of instruction have become more prominent in the industry worldwide. Evaluating the mechanisms that comprise the various international instructional programs, such as the training devices and hours accrued in these devices, is important in understanding how they affect and influence proficiency levels and safety

Pilot Perceptions on Impact of Crew Rest Regulations on Safety and Fatigue

The risk of fatigue on pilot performance and safety is well recognized in aviation. In response to increased safety concerns, the Federal Aviation Administration addressed fatigue risk for passenger airline pilots in Title 14 Code of Federal Regulations Part 117, which included accommodations to address fatigue related risk-factors such as circadian rhythm and the phenomenon commonly described as jet-lag. The rule became effective in January 2014. A survey was conducted in March and April of 2014 to better understand pilot perceptions of the new Part 117 rule. This study analyzed survey responses from 92 self-identified pilots to determine the effect of these new regulations on pilot perception of safety and level of fatigue. The analysis of survey responses to 5-point Likert-scale questions suggested that 43% of pilots felt a positive impact on overall safety, contrasted to 30% of pilots who felt a negative impact on overall safety. Twenty-seven percent of pilots indicated that Part 117 did not have an impact on safety. For perceived level of fatigue, 35% of participants felt a positive impact of Part 117, whereas 33% of participants indicated a negative impact on their fatigue level. Thirty-three percent of participants felt no impact of Part 117 on their overall fatigue level. When asked if cargo operations should be included in the new regulations, 79% of respondents agreed. A qualitative analysis of open-ended comments provided by pilots revealed that negative perceptions of the new regulations were most frequently mentioned

System for and method of performing evaluation techniques on a log or round timber

A system for and method of evaluating a log. The system includes an analysis module having at least one input terminal connectable to the at least one input device. The at least one input terminal is operable to receive at least one signal representing at least one measured property of the log and at least one determined parameter of the log determined in response to an energy being applied to the log. The analysis module further includes a processor coupled to the at least one input terminal. The processor determines a predictive modulus of elasticity (MOE) of the log based at least in part on the at least one measured property and the at least one sensed parameter. The analysis module also includes an output terminal coupled to the processor and connectable to an output device. The output terminal transmits a third signal representing the predictive MOE.https://digitalcommons.mtu.edu/patents/1042/thumbnail.jp

Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever

<p>Abstract</p> <p>Background</p> <p>Lassa fever is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic. Treatment of acute Lassa fever infections has successfully utilized intravenous administration of ribavirin, a nucleotide analogue drug, but this is not an approved use; efficacy of oral administration has not been demonstrated. To date, several potential new vaccine platforms have been explored, but none have progressed toward clinical trials and commercialization. Therefore, the development of a robust vaccine platform that could be generated in sufficient quantities and at a low cost per dose could herald a subcontinent-wide vaccination program. This would move Lassa endemic areas toward the control and reduction of major outbreaks and endemic infections. To this end, we have employed efficient mammalian expression systems to generate a Lassa virus (LASV)-like particle (VLP)-based modular vaccine platform.</p> <p>Results</p> <p>A mammalian expression system that generated large quantities of LASV VLP in human cells at small scale settings was developed. These VLP contained the major immunological determinants of the virus: glycoprotein complex, nucleoprotein, and Z matrix protein, with known post-translational modifications. The viral proteins packaged into LASV VLP were characterized, including glycosylation profiles of glycoprotein subunits GP1 and GP2, and structural compartmentalization of each polypeptide. The host cell protein component of LASV VLP was also partially analyzed, namely glycoprotein incorporation, though the identity of these proteins remain unknown. All combinations of LASV Z, GPC, and NP proteins that generated VLP did not incorporate host cell ribosomes, a known component of native arenaviral particles, despite detection of small RNA species packaged into pseudoparticles. Although VLP did not contain the same host cell components as the native virion, electron microscopy analysis demonstrated that LASV VLP appeared structurally similar to native virions, with pleiomorphic distribution in size and shape. LASV VLP that displayed GPC or GPC+NP were immunogenic in mice, and generated a significant IgG response to individual viral proteins over the course of three immunizations, in the absence of adjuvants. Furthermore, sera from convalescent Lassa fever patients recognized VLP in ELISA format, thus affirming the presence of native epitopes displayed by the recombinant pseudoparticles.</p> <p>Conclusions</p> <p>These results established that modular LASV VLP can be generated displaying high levels of immunogenic viral proteins, and that small laboratory scale mammalian expression systems are capable of producing multi-milligram quantities of pseudoparticles. These VLP are structurally and morphologically similar to native LASV virions, but lack replicative functions, and thus can be safely generated in low biosafety level settings. LASV VLP were immunogenic in mice in the absence of adjuvants, with mature IgG responses developing within a few weeks after the first immunization. These studies highlight the relevance of a VLP platform for designing an optimal vaccine candidate against Lassa hemorrhagic fever, and warrant further investigation in lethal challenge animal models to establish their protective potential.</p

Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury

Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF. METHODS: Using a mouse eccentric limb injury model, we characterized the protective effects of prolyl hydroxylase inhibitor, GSK1120360A. We then extended these studies to examine the impact of EPO modulation and infiltrating immune cell populations on muscle protection. Finally, we extended this study with an experimental medicine approach using eccentric arm exercise in untrained volunteers to measure the muscle-protective effects of a clinical prolyl hydroxylase inhibitor, daprodustat. RESULTS: GSK1120360A dramatically prevented functional deficits and histological damage, while accelerating recovery after eccentric limb injury in mice. Surprisingly, this effect was independent of EPO, but required myeloid HIF1α-mediated iNOS activity. Treatment of healthy human volunteers with high-dose daprodustat reduced accumulation of circulating damage markers following eccentric arm exercise, although we did not observe any diminution of functional deficits with compound treatment. CONCLUSION: The results of these experiments highlight a novel skeletal muscle protective effect of prolyl hydroxylase inhibition via HIF-mediated expression of iNOS in macrophages. Partial recapitulation of these findings in healthy volunteers suggests elements of consistent pharmacology compared to responses in mice although there are clear differences between these two systems

Effectief ontwikkelings­­­be­leid vergt cultuur van leren en betere evaluaties

Het Nederlandse ministerie van Buitenlandse Zaken spant zich in om de impact van ontwikkelingsprojecten te (laten) evalueren. Momenteel worden monitoring en evaluaties hoofdzakelijk ontworpen voor verantwoordingsdoeleinden, en zijn het soms alleen maar ‘afvinkoefeningen’. Hoe zou dit beter kunnen