Une chercheuse à l’énergie durable

Directrice de recherche au CNRS et chargée de mission pour la chimie à l’Institut écologie et environnement (INEE), Isabelle Rico-Lattes coordonne le programme interdisciplinaire du CNRS « Chimie pour le développement durable ». À son palmarès, l’invention et la commercialisation de molécules thérapeutiques utilisées dans le traitement du décollement de la rétine ou celui de peaux atopiques atteintes d’eczéma

Potential blood substitutes synthesis and microemulsification of mixed hydrogenated and fluorinated oils

A synthetic method for preparation of mixed hydrogenated and fluorinated oils of general formula RF-CH2∼CH = CH-Rn in which the fluorinated and hydrogenated parts could be altered at will is described. For the first time, fluorinated oils which have a high capacity for oxygen have been microemulsified using a hydrogenated surfactant (ionic or non-ionic) opening new perspectives for the production of blood substitutes

Synthese d'alkylphenols ethoxyles monodisperses : premier exemple de reaction par transfert de phase catalysee par le formamide

A new simple synthetic method of preparation of ethoxylated octylphenols is described with good yields , using formamide as phase transfer catalyst

A new formulation for blood substitues

The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH-CH-C4H9 with a biocompatible hy-drogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17-CH2-CH = CH-C4H9 was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications