Philile Matshiza lead guitarist of the Black Slave belts it out at St Stephen's Hall.

Clipping of an artlice with pictures of band members of the Black Slave, Ghetto and Lagunya.Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-ShareAlike" License (http://creativecommons.org/licenses/by-nc-sa/2.0/) (NEVER CAHNGE THIS FIELD

'Cut and push’ as an alternative to endoscopic retrieval of PEG type gastrostomy tubes

PurposePercutaneous Endoscopically placed Gastrostomy (PEG) tubes are frequently used in children. The traditional endoscopic method to remove/change the PEG device requires general anaesthesia in children. A minimally invasive alternative is the ‘Cut and Push’ method (C&amp;P): avoiding the risks/wait times of general anaesthesia and reducing resource burden. Data regarding the safety/effectiveness of C&amp;P in children are lacking with concerns raised about the possibility of gastrointestinal obstruction.MethodsWe retrospectively reviewed all cases of PEG removal / change to button in children (&lt; 18 years) between December 2020 and January 2022. Cases were identified from a prospectively maintained database and all cases of C&amp;P included. Parents/carers were asked if the child had suffered any complications following C&amp;P and if flange was visualised in stools.ResultsDuring the time period, 27 PEGs were either removed or changed to button via C&amp;P. The average waiting time for C&amp;P was 14.29 days, significantly shorter than the minimum 6-month waiting time for elective endoscopy. Our evaluation revealed no complications of C&amp;P at median 70 days (range 25–301). In three cases the flange was visualised in the stool, at 2 days, 3 days and 5 weeks following C&amp;P respectively.DiscussionThese data support the available literature suggesting C&amp;P is an effective means to facilitate minimally invasive and prompt PEG removal/change to button in children. We recommend minimum weight and age parameters for this procedure and further evaluation of the safety and resource implications of this technique.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00383-023-05382-5. <br/

Baseline clinical predictors of antitumor response to the PARP inhibitor olaparib in germline BRCA1/2 mutated patients with advanced ovarian cancer.

BackgroundThe PARP inhibitor olaparib was recently granted Food and Drug Administration (FDA) accelerated approval in patients with advanced BRCA1/2 mutation ovarian cancer. However, antitumor responses are observed in only approximately 40% of patients and the impact of baseline clinical factors on response to treatment remains unclear. Although platinum sensitivity has been suggested as a marker of response to PARP inhibitors, patients with platinum-resistant disease still respond to olaparib.Results108 patients with advanced BRCA1/2 mutation ovarian cancers were included. The interval between the end of the most recent platinum chemotherapy and PARPi (PTPI) was used to predict response to olaparib independent of conventional definition of platinum sensitivity. RECIST complete response (CR) and partial response (PR) rates were 35% in patients with platinum-sensitive versus 13% in platinum-resistant (p&lt;0.005). Independent of platinum sensitivity status, the RECIST CR/PR rates were 42% in patients with PTPI greater than 52 weeks and 18% in patients with PTPI less than 52 weeks (p=0.016). No association was found between baseline clinical factors such as FIGO staging, debulking surgery, BRCA1 versus BRCA2 mutations, prior history of breast cancer and prior chemotherapy for breast cancer, and the response to olaparib.MethodsWe conducted an international multicenter retrospective study to investigate the association between baseline clinical characteristics of patients with advanced BRCA1/2 mutation ovarian cancers from eight different cancer centers and their antitumor response to olaparib.ConclusionPTPI may be used to refine the prediction of response to PARP inhibition based on the conventional categorization of platinum sensitivity