Amniotic fluid insulin-like growth factor binding protein 3 concentration as early indicator of fetal growth restriction.

OBJECTIVE: Insulin-like growth factor-I (IGF-I) is an important regulator of fetal growth and its bioavailability depends on insulin-like growth factor binding proteins (IGFBPs). Genes coding for IGF-I and IGFBP3 are polymorphic. We hypothesized that either amniotic fluid protein concentration at the beginning of the second trimester or genotype of one of these two genes could be predictive of abnormal fetal growth. STUDY DESIGN: Amniotic fluid samples (14-18 weeks of pregnancy) from 123 patients with appropriate for gestational age (AGA) fetuses, 39 patients with small for gestational age (SGA) fetuses and 34 patients with large for gestational age (LGA) were analyzed. Protein concentrations were evaluated by ELISA and gene polymorphisms by PCR. RESULTS: Amniotic fluid IGFBP3 concentrations were significantly higher in SGA compared to AGA group (P=0.030), and this was even more significant when adjusted to gestational age at the time of amniocentesis and other covariates (ANCOVA analysis: P=0.009). Genotypic distribution of IGF-I variable number of tandem repeats (VNTR) polymorphism was significantly different in SGA compared to AGA group (P=0.029). 19CA/20CA genotype frequency was threefold decreased in SGA compared to AGA group and the risk of SGA occurrence of this genotype was decreased accordingly: OR=0.289, 95%CI=0.1-0.9, P=0.032. Genotype distribution of IGFBP3(A-202C) polymorphism was similar in all three groups. CONCLUSIONS: High IGFBP3 concentrations in amniotic fluid at the beginning of the second trimester are associated with increased risks of SGA while 19CA/20CA genotype at IGF-I VNTR polymorphism is associated with reduced risks of SGA. Neither IGFBP3 concentrations, nor IGF-I/IGFBP3 polymorphisms are associated with modified risks of LGA

UAV-based canopy textures assess changes in forest structure from long-term degradation

Degraded tropical forests dominate agricultural frontiers and their management is becoming an urgent priority. This calls for a better understanding of the different forest cover states and cost-efficient techniques to quantify the impact of degradation on forest structure. Canopy texture analyses based on Very High Spatial Resolution (VHSR) optical imagery provide proxies to assess forest structures but the mechanisms linking them with degradation have rarely been investigated. To address this gap, we used a lightweight Unmanned Aerial Vehicle (UAV) to map 739 ha of degraded forests and acquire both canopy VHSR images and height model. Thirty-three years of degradation history from Landsat archives allowed us to sample 40 plots in undisturbed, logged, over-logged and burned and regrowth forests in tropical forested landscapes (Paragominas, Para, Brazil). Fourier (FOTO) and lacunarity textures were used to assess forest canopy structure and to build a typology linking degradation history and current states. Texture metrics capture canopy grain, heterogeneity and openness gradients and correlate with forest structure variability (R2 = 0.58). Similar structures share common degradation history and can be discriminated on the basis of canopy texture alone (accuracy = 55%). Over-logging causes a lowering in forest height, which brings homogeneous textures and of finer grain. We identified the major changes in structures due to fire following logging which changes heterogeneous and intermediate grain into coarse textures. Our findings highlight the potential of canopy texture metrics to characterize degraded forests and thus be used as indicators for forest management and degradation mitigation. Inexpensive and agile UAV open promising perspectives at the interface between field inventory and satellite characterization of forest structure using texture metrics

Energy harvesting from the beating heart by a mass imbalance oscillation generator

Energy-harvesting devices attract wide interest as power supplies of today's medical implants. Their long lifetime will spare patients from repeated surgical interventions. They also offer the opportunity to further miniaturize existing implants such as pacemakers, defibrillators or recorders of bio signals. A mass imbalance oscillation generator, which consists of a clockwork from a commercially available automatic wrist watch, was used as energy harvesting device to convert the kinetic energy from the cardiac wall motion to electrical energy. An MRI-based motion analysis of the left ventricle revealed basal regions to be energetically most favorable for the rotating unbalance of our harvester. A mathematical model was developed as a tool for optimizing the device's configuration. The model was validated by an in vitro experiment where an arm robot accelerated the harvesting device by reproducing the cardiac motion. Furthermore, in an in vivo experiment, the device was affixed onto a sheep heart for 1 h. The generated power in both experiments-in vitro (30 μW) and in vivo (16.7 μW)-is sufficient to power modern pacemakers

European congresses of accounting: a review of their history

The history and scientific development of many professions can be studied from the evidence of their annual or occasional conventions. Typically professions originated in major towns and were brought together nationally through state recognition. Subsequently and especially in the twentieth century, international links and co-ordinating professional bodies have been founded. The accountancy profession has gone through these stages. The processes for national recognition and for statutory powers have been well studied. Less attention has been given, however, to the agendas and effectiveness of accountants' congresses at national, European and international level. Evidence has been available on an American conference in 1904; and this has been declared the first of a series of international accounting congresses which continues today. More frequent and more international congresses based in Europe (and in Brussels in particular) deserve attention now, such as has been denied them for some fifty years. The present review is based largely on secondary sources; but it shows the aims of European conferences, which were often occasioned by international expositions, and which evolved from the qualified success of national accountants' conventions. The achievements of congresses are also discussed, in relation to agendas which reveal contrasting expectancies from state intervention and an inverse defence of professional freedoms. The views expressed by accountants differ according to their country of origin and to changing economic climates and conflicting political views. Continental European accountants rather often betray some envy of the state recognition and protection accorded to British chartered accountants.