Octet-baryon masses in finite space

We report on a recent study of finite-volume effects on the lowest-lying octet baryon masses using the covariant baryon chiral perturbation theory up to next-to-leading order by analysing the latest $n_f = 2 + 1$ lattice QCD results from the NPLQCD Collaboration.Comment: 4 pages, 1 figure; parallel talk delivered by XLR at the 14th national conference on nuclear structure, April 12nd - 16th, 2012, Huzhou, Chin

Biologics for the treatment of chronic rhinosinusitis with nasal polyps : state of the art

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex upper airway disease affecting up to 11% of the population of Western Europe. In these western countries, 85% of the CRSwNP disease reveals a type 2 inflammatory pattern. In the last 15 years, several randomized double-blind studies on monoclonal antibodies in CRSwNP were performed. These studies demonstrated for the first time that biologics targeting type 2 immune reactions might be successful in nasal polyps. The target proteins, interleukin (IL)-4, IL-5, IL-13, and IgE were previously identified as key mediators in studies using nasal polyp tissues to measure and to interact in ex-vivo settings. No biomarkers have been identified to predict response to a specific biologic or to monitor treatment success. These studies were characterized by small numbers of patients and heterogeneous populations. They did, however, pave the way for currently performed and analyzed phase 3 studies, which will possibly lead to the registration of the first biologic drug with the indication CRSwNP. The studies already provide indications on the effects to be expected from those biologics; the results of phase-3 studies in larger populations will be decisive for the indications, patient selection, and finally the stopping rules for those drugs in subjects with severe nasal polyps, in whom the current standard of care including topical and oral glucocorticosteroids, antibiotics and surgical procedures failed to control the disease. We may expect that those biologics will open new perspectives for those patients with severe polyposis with, but also independent of asthma, allowing to avoid the possible adverse events resulting from systemic glucocorticosteroids and surgery

Scalar strangeness content of the nucleon and baryon sigma terms

The scalar strangeness content of the nucleon, characterized by the so-called strangeness-nucleon sigma term, is of fundamental importance in understanding its sea-quark flavor structure. We report a determination of the octet baryon sigma terms via the Feynman-Hellmann theorem by analyzing the latest high-statistics $n_f=2+1$ lattice QCD simulations with covariant baryon chiral perturbation theory up to next-to-next-to-next-to-leading order. In particular, we predict $\sigma_{\pi N}=55(1)(4)$ MeV and $\sigma_{sN}=27(27)(4)$ MeV, while the first error is statistical and the second systematic due to different lattice scales. The predicted $\sigma_{sN}$ is consistent with the latest LQCD results and the results based on the next-to-next-to-leading order chiral perturbation theory. Several key factors in determining the sigma terms are systematically taken into account and clarified for the first time, including the effects of lattice scale setting, systematic uncertainties originating from chiral expansion truncations, and constraint of strong-interaction isospin breaking effects.Comment: 6 pages, 2 figures; version to appear in Physical Review