The 108th AAA Group invaded Fortress Europe 27 June 1944

Headquarters and Headquarters Battery 1 08th Antiaircraft Artillery Group, a new organization in the annals of United States military history, has had a rich and important part in the successful prosecution of this Second Great War just ended. Activated 1 March 1942 at Camp Davis, North Carolina, as Headquarters and Headquarters Battery 514th Coast Artillery (Antiaircraft) the Group had had the responsibility for providing demonstration, instruction and maintenance personnel for the Antiaircraft School and Antiaircraft Board until October 1943.https://digicom.bpl.lib.me.us/ww_reg_his/1004/thumbnail.jp

Modulation of Pain with Transcranial Direct Current Stimulation and Diffuse Noxious Inhibitory Controls

Background: While pain is essential for physiological functioning, chronic or pathologic pain is responsible for a major burden of disease in society. Novel approaches to treating acute and chronic pain have employed neuromodulatory tools to target the central and peripheral neural structures that mediate pain. Transcranial direct current stimulation (tDCS), for example, is a safe, non-invasive brain stimulation technique that has been shown in preliminary studies to reduce chronic pain when applied to the primary motor cortex. In contrast to this exogenous neuromodulatory approach, diffuse noxious inhibitory controls (DNIC) refers to endogenous pain regulatory mechanisms that decrease pain following introduction of heterotopic noxious stimuli. This thesis explores whether combining these exogenous and endogenous pain modulation approaches synergistically increases the threshold at which pain is perceived. Methods: We conducted a double-blinded, randomized, placebo-controlled trial with a crossover design to investigate the effects of tDCS and DNIC on pain thresholds in 15 healthy human subjects. Pain thresholds were assessed prior to and following administration of active tDCS, sham tDCS, cold-water-induced DNIC, and combined active tDCS and DNIC. Using magnetic resonance spectroscopy, we examined whether baseline concentrations of brain metabolites such as N-acetylaspartate in pain-related regions of interest were associated with responses to the varying neuromodulatory conditions. Results: Pain thresholds significantly increased following both active tDCS and the DNIC paradigm. These modulatory approaches appeared to have additive effects when combined. Pain threshold increases after active tDCS were positively correlated with baseline levels of N-acetylaspartate, a marker of good neural function, in the anterior cingulate cortex and negatively correlated with baseline levels of glutamine in the thalamus. Conclusions: Combining endogenous pain regulatory mechanisms with exogenous stimulation of the motor cortex can more effectively increase pain thresholds in healthy humans. Future studies should examine whether existing pain therapies may be enhanced with noninvasive brain stimulation and activation of DNIC. They should also assess whether brain metabolite levels can be utilized to predict clinical response to therapeutic interventions

Resonance Broadening Induced Nonlinear Saturation of Kinetic Alfven Turbulence in the Interplanetary Plasma

The saturation of ion cyclotron Alfven turbulence excited by beam particles is investigated using resonance broadening theory. The stochastic scattering which decorrelates particles, includes both random acceleration by electric fields and a turbulent magnetic mirroring effect. Turbulent mirroring is shown to yield non-Gaussian corrections to the orbits even if the random electric and magnetic fields are Gaussian. The predicted steady-state turbulence level exhibits a peaked anglular distribution, with a maximum near Theta ~ 60 degrees.Comment: 5 pages (including 2 figures

Keratinocyte cytoskeletal roles in cell sheet engineering

Background: There is an increasing need to understand cell-cell interactions for cell and tissue engineering purposes, such as optimizing cell sheet constructs, as well as for examining adhesion defect diseases. For cell-sheet engineering, one major obstacle to sheet function is that cell sheets in suspension are fragile and, over time, will contract. While the role of the cytoskeleton in maintaining the structure and adhesion of cells cultured on a rigid substrate is well-characterized, a systematic examination of the role played by different components of the cytoskeleton in regulating cell sheet contraction and cohesion in the absence of a substrate has been lacking. Results: In this study, keratinocytes were cultured until confluent and cell sheets were generated using dispase to remove the influence of the substrate. The effects of disrupting actin, microtubules or intermediate filaments on cell-cell interactions were assessed by measuring cell sheet cohesion and contraction. Keratin intermediate filament disruption caused comparable effects on cell sheet cohesion and contraction, when compared to actin or microtubule disruption. Interfering with actomyosin contraction demonstrated that interfering with cell contraction can also diminish cell cohesion. Conclusions: All components of the cytoskeleton are involved in maintaining cell sheet cohesion and contraction, although not to the same extent. These findings demonstrate that substrate-free cell sheet biomechanical properties are dependent on the integrity of the cytoskeleton network