Design & development of a novel house hold compressing device for a wheelie bin

This project consists of researching, designing, developing, prototyping and testing a device that clamps onto a wheelie bin and easily compresses the waste inside. Once attached, by pulling on the lever, the device will compress the contents inside allowing for disposal of more waste. The design is easily assembled, light and sturdy enough so that any household individual can use it. Prototype testing was performed to identify the required forces necessary to compress a sufficient amount of waste and identifying which materials or types of waste can be compressed. The prototype testing showed that the device is capable of compressing the normal household wastes (compressing plastic bottles, cardboards, tin cartons) up to 45% off the original volume. The paper discusses the design, development and testing of this device to appreciate the proof of the concept as well as discussing it in terms of saving the cost of recycling as well

Application of context knowledge in supporting conceptual design decision making

Conceptual design is the most important phase of the product life cycle as the decisions taken at conceptual design stage affect the downstream phases (manufacture, assembly, use, maintenance, and disposal) in terms of cost, quality and function performed by the product. This research takes a holistic view by incorporating the knowledge related to the whole context (from the viewpoint of product, user, product's life cycle and environment in which the product operates) of a design problem for the consideration of the designer to make an informed decision making at the conceptual design stage. The design context knowledge comprising knowledge from these different viewpoints is formalised and a new model and corresponding computational framework is proposed to support conceptual design decision making using this formalised context knowledge. Using a case study, this paper shows the proof of the concept by selecting one concept among different design alternatives using design context knowledge thereby proactively supporting conceptual design decision making for an informed and effective decision making

Structural studies of the DNA partitioning protein IncC from the plasmid RK2

Plasmid DNA partitioning is a crucial process for the transfer of at least a single copy of plasmid to the daughter cells during bacterial cell division. Partitioning for various low-copy number plasmids involves a DNA-binding protein (ParB), a centromere-like DNA site ( parS) and a ParA-family protein. Interestingly, the RK2 plasmid encodes two ParA proteins of different lengths. The longer protein is IncC1 (364 a.a), while IncC2 lacks a N- terminal domain of 105 amino acids (IncC NTD). The secondary structure of IncC NTD by NMR spectroscopy and other biophysical methods has been determined as random coil. It appears to bind DNA weakly and non-specifically. The expression and purification of IncC1 and IncC2 proteins was optimized. The two proteins and IncC NTD were characterized using various biophysical methods including Circular Dichroism, Analytical Ultracentrifugation, Small Angle X-ray Scattering, Size Exclusion Chromatography-Multi Angle Light Scattering, and EMSAs. Bacterial two hybrid assays and chemical crosslinking showed the two IncC proteins form homo- and hetero-dimers and interact with KorB protein. IncC1 and IncC2 proteins bind to DNA, non-specifically. IncC1 binds DNA weakly in the absence of nucleotides but IncC2 protein was found to bind DNA only in the presence of nucleotides (ADP, ATP)

Revisiting the nexus between exchange rate, exports and economic growth: further evidence from Asia

The economic growth of developing countries has been associated with their exports, and the existing research suggests that exchange rates significantly influence the exports. This study used panel data to investigate the potential nexus of gross domestic product (GDP), exports and exchange rates in Asian countries over the period of 1981–2016. The results portray that nexus between exchange rate and exports holds true for Export-led Growth (ELG) and Growth-led Exports (GLE) hypotheses. This study used the Wald test under Vector Error Correction Model (VECM) with all necessary specifications tests to identify the possible nexus of variables, and applied the fixed effects model along with control variables. The results imply that an undervalued currency enhances exports and has a significant impact on economic growth. Additionally, the results of Fully Modified Ordinary Least Squares (FMOLS) model with financial crises dummy suggested that the estimations are robust. Keeping in view the aforementioned findings, a timely and balanced policy can play a pivotal role in improving the long term nexus of exchange rates, exports and economic growth