Additional file 3: Table S3. of Modification of the association between recreational physical activity and survival after breast cancer by promoter methylation in breast cancer-related genes

Age-adjusted HRs and 95% CIs for the association between lifetime recreational physical activity (RPA) and 15-year all-cause and breast cancer-specific mortality stratified by gene methylation status (methylated vs. unmethylated tumors) among 803 women diagnosed with a first primary hormone receptor-positive breast cancer and with available gene promoter methylation data, Long Island Breast Cancer Study Project. (DOC 56 kb

Meta-analysis of the association between genetically predicted BMI and breast cancer risk in the BCAC.

<p>The summary OR was calculated by combining individual analysis results from each study in BCAC (<i>p</i> for heterogeneity = 0.06).</p

Sensitivity analyses using pooled data for associations between genetically predicted BMI and breast cancer risk in the BCAC.

<p>(A) Adjusted for age, study sites, and the first eight principal components. (b) Adjusted for age, study sites, the first eight principal components, and additional breast cancer risk factors: age at menarche, parity, use of contraceptive, use of hormone replacement therapy, breast feeding, and smoking status. Weighted: the BMI-GS was constructed using the additive model weighted by external beta reported from previous literatures. Unweighted: the BMI-GS was constructed using the additive model without any weight.</p

Associations of the weighted BMI-GSs with BMI and traditional breast cancer risk factors.

<p>Associations of the weighted BMI-GSs with BMI and traditional breast cancer risk factors.</p

Associations between genetically predicted BMI and breast cancer risk.

<p>Associations between genetically predicted BMI and breast cancer risk.</p

Significant associations detected at <i>p</i> < 0.05 between breast cancer risk and BMI-related SNPs.

<p>Significant associations detected at <i>p</i> < 0.05 between breast cancer risk and BMI-related SNPs.</p