Motor prognosis and current perspectives in cerebral palsy

A paralisia cerebral é uma sequela de agressão encefálica caracterizada por transtorno motor não evolutivo quanto à sua lesão. De acordo com o local da lesão pode provocar diferentes seqüelas que resultam em incapacidade funcional. OBJETIVO: revisar de forma não sistemática sobre o tema paralisia cerebral, enfocando o seu prognóstico motor, incluindo expectativa de vida e funcionalidade. MÉTODO: utilização das bases de dados Medline e LILACS, dos últimos quinze anos, com os unitermos paralisia cerebral, quadriplegia, diplegia, hemiplegia, prognóstico. RESULTADOS: foram listados 474 artigos científicos, sendo selecionados para esta revisão 34 artigos com base em: título, resumo, assunto, originalidade e disponibilidade de acesso pelo portal da CAPES. Foram identificadas as variáveis que podem influenciar o prognóstico motor nas crianças com paralisia cerebral. O prejuízo motor das crianças com paralisia cerebral está diretamente relacionado com o nível de gravidade da paralisia cerebral, assistência terapêutica e o tipo apresentado pelas crianças. Os pacientes com hemiplegia resultante de paralisia cerebral apresentam um prognóstico motor mais favorável comparado aos diplégicos e quadriplégicos.Cerebral palsy it is a consequence characterized by non-progressive motor disturbance referring to his lesion. According to the lesion area, can promote different outcomes that result in functional disabilities. OBJECTIVE: to review by non-systematic way the theme cerebral palsy focusing motor prognosis, including life expectancy and functionality. METHODS: using the Medline and LILACS, data bases searching for the last fifteen years with the terms cerebral palsy, quadriplegia, diplegia, hemiplegia, prognosis. RESULTS: a total of 474 scientific papers were listed and 34 select based on: title, abstract, subject, original article and access through CAPES homepage. Were identified variables that could affect motor prognosis in children with cerebral palsy. The motor impairment from children is directly related to cerebral palsy severity level, therapeutic assistance and cerebral palsy type presented in children. The patients with hemiplegic cerebral palsy showed most favorable motor outcomes compared to diplegic and quadriplegic ones

Update of the Brazilian consensus recommendations on Duchenne muscular dystrophy

In the last few decades, there have been considerable improvements in the diagnosis and care of Duchenne muscular dystrophy (DMD), the most common childhood muscular dystrophy. International guidelines have been published and recently reviewed. A group of Brazilian experts has developed a standard of care based on a literature review with evidence-based graded recommendations in a two-part publication. Implementing best practice management has helped change the natural history of this chronic progressive disorder, in which the life expectancy for children of the male sex in the past used to be very limited. Since the previous publication, diagnosis, steroid treatment, rehabilitation, and systemic care have gained more significant insights with new original work in certain fields. Furthermore, the development of new drugs is ongoing, and some interventions have been approved for use in certain countries. Therefore, we have identified the need to review the previous care recommendations for Brazilian patients with DMD. Our objective was to create an evidence-based document that is an update on our previous consensus on those topics