Impact of Early Relapse within 24 Months after First-Line Systemic Therapy (POD24) on Outcomes in Patients with Marginal Zone Lymphoma: A US Multisite Study

Progression of disease within 24 months (POD24) from diagnosis in marginal zone lymphoma (MZL) was shown to portend poor outcomes in prior studies. However, many patients with MZL do not require immediate therapy, and the time from diagnosis-to-treatment interval can be highly variable with no universal criteria to initiate systemic therapy. Hence, we sought to evaluate the prognostic relevance of early relapse or progression within 24 months from systemic therapy initiation in a large US cohort. The primary objective was to evaluate the overall survival (OS) in the two groups. The secondary objective included the evaluation of factors predictive of POD24 and the assessment of cumulative incidence of histologic transformation (HT) in POD24 versus non-POD24 groups. The study included 524 patients with 143 (27%) in POD24 and 381 (73%) in non-POD24 groups. Patients with POD24 had inferior OS compared to those without POD24, regardless of the type of systemic therapy received (rituximab monotherapy or immunochemotherapy) at diagnosis. After adjusting for factors associated with inferior OS in the univariate Cox model, POD24 remained associated with significantly inferior OS (HR = 2.50, 95% CI = 1.53-4.09, p = 0.0003) in multivariable analysis. The presence of monoclonal protein at diagnosis and those who received first-line rituximab monotherapy had higher odds of POD24 on logistic regression analysis. Patients with POD24 had a significantly higher risk for HT compared to those without POD24. POD24 in MZL might be associated with adverse biology and could be used as an additional information point in clinical trials and investigated as a marker for worse prognosis

A Market-Window Analysis for Crown-Cut Broccoli Produced in Southwest Virginia

This research determines the profitability for farmers of marketing film-wrapped Crown-Cut broccoli in Southwest Virginia. Historical price data was collected in three eastern terminal markets (Atlanta, Baltimore, and Philadelphia) for Crown-Cut and bunched broccoli from October 1998 to January 2005. Cost-of-production budgets were estimated for Crown-Cut broccoli. The economic data was entered into a market window analysis and the profitability of each market was evaluated. The profitability of Crown-Cut broccoli was illustrated by market-window graphics. Market windows were generated using an analysis platform developed by Kalo (1998). The profitability estimates were calculated by posting historical market prices by week in a Microsoft Excel spreadsheet and subtracting corresponding unit costs for transportation and production. Study results show that there is potential profit for producing Crown-Cut broccoli during the first weeks of October. Atlanta proved to have the most profit potential of the three markets studied. Given the frost dates in the area, these production windows favor broccoli production without weather risk. Southwestern Virginia should consider developing Crown-Cut production options: the early open market windows combined with the potential for reducing production costs by double-cropping means that a potential profit opportunity exists

A Market-Window Analysis for Crown-Cut Broccoli Produced in Southwest Virginia

This research determines the profitability for farmers of marketing film-wrapped Crown-Cut broccoli in Southwest Virginia. Historical price data was collected in three eastern terminal markets (Atlanta, Baltimore, and Philadelphia) for Crown-Cut and bunched broccoli from October 1998 to January 2005. Cost-of-production budgets were estimated for Crown-Cut broccoli. The economic data was entered into a market window analysis and the profitability of each market was evaluated. The profitability of Crown-Cut broccoli was illustrated by market-window graphics. Market windows were generated using an analysis platform developed by Kalo (1998). The profitability estimates were calculated by posting historical market prices by week in a Microsoft Excel spreadsheet and subtracting corresponding unit costs for transportation and production. Study results show that there is potential profit for producing Crown-Cut broccoli during the first weeks of October. Atlanta proved to have the most profit potential of the three markets studied. Given the frost dates in the area, these production windows favor broccoli production without weather risk. Southwestern Virginia should consider developing Crown-Cut production options: the early open market windows combined with the potential for reducing production costs by double-cropping means that a potential profit opportunity exists.Crop Production/Industries, Marketing,

Abstracts of Tanzania Health Summit 2020

This book contains the abstracts of the papers/posters presented at the Tanzania Health Summit 2020 (THS-2020) Organized by the Ministry of Health Community Development, Gender, Elderly and Children (MoHCDGEC); President Office Regional Administration and Local Government (PORALG); Ministry of Health, Social Welfare, Elderly, Gender, and Children Zanzibar; Association of Private Health Facilities in Tanzania (APHFTA); National Muslim Council of Tanzania (BAKWATA); Christian Social Services Commission (CSSC); & Tindwa Medical and Health Services (TMHS) held on 25–26 November 2020. The Tanzania Health Summit is the annual largest healthcare platform in Tanzania that attracts more than 1000 participants, national and international experts, from policymakers, health researchers, public health professionals, health insurers, medical doctors, nurses, pharmacists, private health investors, supply chain experts, and the civil society. During the three-day summit, stakeholders and decision-makers from every field in healthcare work together to find solutions to the country’s and regional health challenges and set the agenda for a healthier future. Summit Title: Tanzania Health SummitSummit Acronym: THS-2020Summit Date: 25–26 November 2020Summit Location: St. Gasper Hotel and Conference Centre in Dodoma, TanzaniaSummit Organizers: Ministry of Health Community Development, Gender, Elderly and Children (MoHCDGEC); President Office Regional Administration and Local Government (PORALG); Ministry of Health, Social Welfare, Elderly, Gender and Children Zanzibar; Association of Private Health Facilities in Tanzania (APHFTA); National Muslim Council of Tanzania (BAKWATA); Christian Social Services Commission (CSSC); & Tindwa Medical and Health Services (TMHS)