Identification of putative cancer genes through data integration and comparative genomics between plants and humans

Coordination of cell division with growth and development is essential for the survival of organisms. Mistakes made during replication of genetic material can result in cell death, growth defects, or cancer. Because of the essential role of the molecular machinery that controls DNA replication and mitosis during development, its high degree of conservation among organisms is not surprising. Mammalian cell cycle genes have orthologues in plants, and vice versa. However, besides the many known and characterized proliferation genes, still undiscovered regulatory genes are expected to exist with conserved functions in plants and humans. Starting from genome-wide Arabidopsis thaliana microarray data, an integrative strategy based on coexpression, functional enrichment analysis, and cis-regulatory element annotation was combined with a comparative genomics approach between plants and humans to detect conserved cell cycle genes involved in DNA replication and/or DNA repair. With this systemic strategy, a set of 339 genes was identified as potentially conserved proliferation genes. Experimental analysis confirmed that 20 out of 40 selected genes had an impact on plant cell proliferation; likewise, an evolutionarily conserved role in cell division was corroborated for two human orthologues. Moreover, association analysis integrating Homo sapiens gene expression data with clinical information revealed that, for 45 genes, altered transcript levels and relapse risk clearly correlated. Our results illustrate how a systematic exploration of the A. thaliana genome can contribute to the experimental identification of new cell cycle regulators that might represent novel oncogenes or/and tumor suppressors

Ecofriendly recycled aggregate concrete and bioreceptivity

Nowadays, it becomes essential to limit environmental impact of building materials and to consider the life cycle of materials used. Recycling of materials from demolition has the dual objective of preserving natural resources and limiting the number of storage sites. The study presented here aims to develop the use of recycled aggregate issued of concrete in total replacement of natural materials (sand and gravel). This work has to be done upstream the studies on bio-corrosion or bio-receptivity of these concrete composed of recycled aggregates. Following an experimental analysis of physical, mechanical and mineralogical properties of recycled aggregates,the influence of these characteristics on choosing formulation parameters of concrete and mortar was studied. It was shown that the use of superplasticizers is necessary to reach satisfactory properties of concrete. The next step of this work will be toanalyse the bio-receptivity of these concrete and compatibilitywith bio-admixture used to decrease bio-receptivity and bio-corrosion; and to develop bio-superplasticizers to replace chemical ones

The Na+/I- cotransporter :a potential autoantigen in thyroid autoimmune disease.

info:eu-repo/semantics/publishe

Etude du contrôle et du rôle physiologique de la cascade du Ca2+-phospatidylinositol du thyrocyte

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Control of the dog thyrocyte plasma membrane iodide permeability.

info:eu-repo/semantics/publishe

Use of Rev-erb family of receptors in screening

Patent application EP1090292 (A1)info:eu-repo/semantics/publishe

METAGENE EXPRESSION SIGNATURE FOR PROGNOSIS OF BREAST CANCER PATIENTS

Application N° / WO2012056047 (A1)info:eu-repo/semantics/publishe

Use of hRORalpha receptors for screening substances useful for the treatment of atherosclerosis

Patent apllication WO9950660 (A1)info:eu-repo/semantics/publishe

Robert Feulgen Lecture 1991. Control and role of major signalling cascades of the thyrocyte.

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Dissociation between the activation of the Ca2+-phosphatidylinositol cascade and the regulation of DNA synthesis in the dog thyrocyte.

info:eu-repo/semantics/publishe