Human bone marrow stroma colonies treated with inhibitors continuously for 2 weeks

<p><b>Copyright information:</b></p><p>Taken from "Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism"</p><p>http://www.biomedcentral.com/1471-2407/7/138</p><p>BMC Cancer 2007;7():138-138.</p><p>Published online 25 Jul 2007</p><p>PMCID:PMC1940258.</p><p></p> (A) The number of colonies, (B) average area of the colonies, (C) and the percentage of coverage of the colonies are shown. Cells were treated in the same manner as described in figure 5. Data points represent the mean ± SD of three independent experiments

Human bone marrow stroma colonies treated with inhibitors for the first week and fresh media for the second week

<p><b>Copyright information:</b></p><p>Taken from "Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism"</p><p>http://www.biomedcentral.com/1471-2407/7/138</p><p>BMC Cancer 2007;7():138-138.</p><p>Published online 25 Jul 2007</p><p>PMCID:PMC1940258.</p><p></p> (A) The number of colonies, (B) average area of the colonies, (C) and the percentage of coverage of the colonies are shown. The corresponding concentration of inhibitors were added to the cells which were plated in IMDM-based Long Term Culture Media containing 25% horse serum and incubated in a humidified chamber containing 5% CQ. Data points represent the mean ± SD of three experiments

Inhibition of proliferation in (A and C) MCF-7 WT or (B and D) MCF-7 ADR cultures with lipoxygenase inhibitors; MK59I, MK886, NDGA for A and B; curcumin, ketoconazole, and AA88I for C and D

<p><b>Copyright information:</b></p><p>Taken from "Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism"</p><p>BMC Cancer 2007;7():138-138.</p><p>Published online 25 Jul 2007</p><p>PMCID:PMC1940258.</p><p></p> Cells were plated in IMEM culture fluid containing 8% FBS, 0.5% penicillin and streptomycin sulfate,0.5% kanamycin sulfate, and 1% MEM Vitamin Solution. Inhibitors were added after 24 hours and the cells were incubated in a humidified chamber of 5% CQfor an additional 48 hours. Thymidine was incorporated 16 hours prior to harvest and the cells were harvested using Packard Unifilter System. Values are expressed as % of the control. Data points represent the mean ± SD of three experiments with samples run in replicates of six

Induction of apoptosis in MCF-7 WT cells with (B) Curcumin, (C) NDGA and (D) MK 886

<p><b>Copyright information:</b></p><p>Taken from "Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism"</p><p>http://www.biomedcentral.com/1471-2407/7/138</p><p>BMC Cancer 2007;7():138-138.</p><p>Published online 25 Jul 2007</p><p>PMCID:PMC1940258.</p><p></p> MCF-7 WT cells were plated in Labtek 8 chamber glass slides for 24 hours and then incubated with the inhibitors for 48 hours. Cells were fixed using paraformaldehyde and stained with HOECHST 33258 dye for 30 minutes. Cells with bright, fragmented, condensed nuclei were identified as apoptotic cells

Cells were treated with each inhibitor and the lipoxygenase activity was determined in treated and control cells

<p><b>Copyright information:</b></p><p>Taken from "Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism"</p><p>http://www.biomedcentral.com/1471-2407/7/138</p><p>BMC Cancer 2007;7():138-138.</p><p>Published online 25 Jul 2007</p><p>PMCID:PMC1940258.</p><p></p> Data points represent the mean ± SD of three experiments with samples run in triplicate

Cluster view of gene expression profiles showing altered regulation of genes induced by VEEV in PBMC

<p><b>Copyright information:</b></p><p>Taken from "Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques ()"</p><p>http://www.virologyj.com/content/4/1/82</p><p>Virology Journal 2007;4():82-82.</p><p>Published online 29 Aug 2007</p><p>PMCID:PMC2042503.</p><p></p> Blood was collected at various time point post exposure to VEEV. RNA was isolated, hybridized to human cDNA arrays, scanned and data analyzed using Gene Spring. Red shows up regulated and green represents down regulated genes compared to control unexposed animals. Cluster analysis was performed using the Hierarchical cluster and Tree view

A comparative analysis of four selected genes using array analysis and Real-time PCR

<p><b>Copyright information:</b></p><p>Taken from "Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques ()"</p><p>http://www.virologyj.com/content/4/1/82</p><p>Virology Journal 2007;4():82-82.</p><p>Published online 29 Aug 2007</p><p>PMCID:PMC2042503.</p><p></p> RNA binding motif protein 9 and collagen, type XV, were down regulated in VEEV infected animals while programmed cell death 4 was down regulated

Expression patterns of androgen related genes: The androgen receptor and the Prostate androgen-regulated transcript 1 (PART1) were both down regulated by the VEEV in the blood of infected animals

<p><b>Copyright information:</b></p><p>Taken from "Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques ()"</p><p>http://www.virologyj.com/content/4/1/82</p><p>Virology Journal 2007;4():82-82.</p><p>Published online 29 Aug 2007</p><p>PMCID:PMC2042503.</p><p></p

Expression patterns of pro-inflammatory genes: RNA samples were isolated and hybridized on the cDNA microarray slides as detailed in materials and methods

<p><b>Copyright information:</b></p><p>Taken from "Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques ()"</p><p>http://www.virologyj.com/content/4/1/82</p><p>Virology Journal 2007;4():82-82.</p><p>Published online 29 Aug 2007</p><p>PMCID:PMC2042503.</p><p></p> Images were analyzed using GenePix 4.0 and data were analyzed using GeneSpring 7.

The genomic candidates associated with three top-ranked neurological diseases: movement disorder (MvD), Alzheimer's disease (AD) and Parkinson's disease (PD).

<p>The genes are identified by the Entrez ID and gene symbol. The log ratio indicates the log_1.5 transformed of the average transcriptomic expression from FD-/SD-fed mice.</p