CURRENT MEASURES AGAINST OPHTHALMIC COMPLICATIONS OF DIABETES MELLITUS-A SHORT REVIEW

Diabetes mellitus (DM) is a metabolic disorder, whose prevalence is predicted to rise shortly. The present review focuses on the various ocular complications associated with DM, and the various ophthalmic formulation approaches developed to treat the same. Diabetic macular edema (DME), diabetic retinopathy, cataracts, and glaucoma are some of the major vision-threatening complications linked to DM. The ocular route of drug delivery has undergone several advancements in recent decades, the introduction of various novel drug delivery systems (DDS), various modifications in the existing formulation approaches, development of custom-designed personalized medications, being some of the major developments introduced in the field of ocular drug delivery. Due to the application of state-of-the-art technologies in the field of innovations related to ocular DDS, patients have been immensely benefited by the current modes of ocular treatment imparting fewer side effects, enhanced penetration, sustained drug effect, and so on. The present review includes and emphasizes the gradual development that has occurred from the conventional ophthalmic dosage forms to the currently reported novel ocular drug delivery approaches along with the related clinical research works

The Application of Nanotechnology and Nanomaterials in Depression: An Updated Review

Depression is the most common stress-related mental illness. It has an impact on millions of individuals globally. Genetic, biochemical, environmental, and psychological elements can all play a role in its development. Medications, psychotherapy, and lifestyle changes are frequently used to treat depression. Antidepressant medications work by altering the levels of certain chem-icals in the brain. At the same time, psychotherapy aims to help individuals better understand and manage their emotions and thoughts, which otherwise may lead to depression. The current treatment strategy for the illness has several drawbacks, such as adverse effects, ineffectiveness, long-term use, stigma, and cost-related issues of the medication used. These negative effects un-derscore the need for more successful and novel methods of treating depression, such as the investigation of medication delivery techniques based on nanotechnology. Increased medication effectiveness, fewer side effects, long-lasting medication effects, a good understanding of the neural underpinnings of depression, and the potential for the creation of personalized medicines are some of the potential benefits of using nanotechnology in depressive disorder treatment. In several scientific domains, nanotechnology has many benefits. Nanoparticles are the fundamen-tal building blocks of nanotechnology in this regard. Nanoparticles hold great promise for use in medical applications, as recently developed nanotechnology has shown. This review focuses on the most popular nanomaterials that are used to treat depression, in addition to how well these nanomaterials are at managing depression based on their physical, chemical, and biological properties. We have also talked about the difficulties that the various nanomaterials face, which limit their uses and prevent the development of effective clinical therapies

Beneficial Remedies of Ayurvedic Medicines Against Allopathic Drugs In Peptic Ulcer

Ayurveda has long been regarded as the most dependable and secure medical system. The effectiveness of Ayurvedic Remedies becomes evident after a certain period of time. These remedies operate by enhancing the immune response or eliciting antagonistic reactions. Ayurvedic treatments utilize substances derived from plants, marine sources, and minerals. These remedies tend to have minimal to no observed side effects due to their natural origin. Here, we compared the Allopathic therapies with Ayurvedic remedies for Peptic Ulcer disease

Recent approaches to combat various infections in eye

The prevalence of various eye related disorder is increasing rapidly among the global population and the microorganism borne ocular infections are emerging as biggest threat to the healthy functioning of eye during the past few years. Conjunctivitis, keratitis, endophthalmitis, blepharitis, uveitis, cellulitis, and ocular herpes are a few of the more common ocular illnesses. The arrival of novel technologies including nanotechnology and ocular implant are giving a hope to the healthcare sector via improved therapeutic potential and safety profile in the field of ocular infections treatment. This article enlisted major ocular infections, along with the physiology, prevention and treatment methods. The review article also highlighted information related to the available treatments for various ocular infections and recent patent insight of emerging technologies.        &nbsp

FORMULATION AND EVALUATION OF NIOSOMAL GEL OF AZELAIC ACID FOR ANTIACNE ACTIVITY

Objective: This study aimed to develop niosomes loaded with azelaic acid (AA) to administer in gel form. The primary objective was to achieve controlled and sustained release of the drug while minimizing potential side effects. Methods: Niosomes were fabricated using a combination of various non-ionic surfactants and cholesterol through the application of thin film hydration technique. Furthermore, the processing parameters were optimized and drug excipient compatibility study was conducted using FTIR spectroscopy. The formulations were extensively characterized in terms of entrapment efficiency, particle size, shape, and in vitro release. Subsequently, the improved niosomal dispersions were employed to formulate gels, which underwent analysis to evaluate their visual properties, pH, and rheological behavior. Stability study was also conducted. Results: Total 15 formulations were prepared, out of which 3 formulations F3, F9 and F15 were found to exhibit maximum entrapment efficiency. These formulation were having particle size 260.1 nm, 272.3 nm and 226.3 nm respectively. In vitro drug release was found to be maximum in F9 formulation. The release was found to be dose-dependent across all formulations, with regression values between 0.97 and 0.99, confirming first-order release kinetics. FTIR spectra indicated the absence of any drug-cholesterol-nonionic surfactant interaction in the formulation. The niosomal gel formulations exhibited optimal performance when stored within the temperature range of 4 to 8 oC. Conclusion: This investigation demonstrates the utility of the thin film hydration technique in effectively incorporating poorly water-soluble medications such as azelaic Acid (AA) into niosomes, resulting in high entrapment efficiency. These findings suggest that niosomes containing AA, when topically applied as a gel, have the potential to be an efficacious treatment for acne

Herbodetox agents: Naturally detox our internal organs

From the skin to the liver, the human body has a built-in detoxification mechanism that keeps it running properly on a daily basis. The natural system has been undermined by our contemporary way of life, which includes increased levels of stress, pollution, and poor eating habits. The identification of naturally occurring herbs that may aid in the cleaning of the urinary system and/or other organs is urgently needed. These plants can be found in abundance in the wild. The actions of herbal agents and pollutants increase the body's vigour while also detoxifying the critical organs. The capacity of nature's detox herbs to cleanse the kidney, liver, intestines, skin, and blood of toxins has been revived in this study that aids the lungs, kidneys, digestive system, and skin