De Gherasim Putneanul a Bonifaciu Florescu – um século de tradução romena da literatura francesa

The following paper is a general presentation of those involved in translating at a decisive time for the modernization of Romanian society. In the second half of the 18th century, Wallachia and Moldavia opened to the West, and especially to France, from where the Enlightenment spread throughout Europe. As a result, a series of religious and secular figures translate moralizing and even scientific writings. The following century represents one of the richest chapters in the history of Romanian translation. It is then that the names of the first women translators were recorded. In their effort to integrate our culture among other important cultures of the continent, translators become language and literary models creators and promoters of new ideas in Romanian society.L’article qui suit se veut une présentation générale de ceux qui se sont impliqués dans la réalisation des traductions à une époque décisive pour la modernisation culturelle et politique de la société roumaine. Dans la deuxième moitié du XVIIIe siècle, la Valachie et la Moldavie s’ouvrent vers l’Occident, et surtout vers la France, d’où l’Illuminisme rayonne dans toute l’Europe. Par conséquent, une pléiade de personnalités religieuses et laïques traduit des écrits à caractère moralisateur, voire scientifique. Le siècle suivant représente l’un des plus riches chapitres de l’histoire des traductions roumaines. C’est à la même époque qu’on recense les noms des premières traductrices. Dans l’effort d’intégrer la culture roumaine parmi les autres cultures importantes du continent, les traducteurs deviennent des créateurs de la langue et des modèles littéraires, des formateurs du goût et les promoteurs des idées nouvelles dans la société roumaine.O presente artigo tem por objetivo realizar uma apresentação geral dos envolvidos na tradução em um momento decisivo para a modernização da sociedade romena. Na segunda metade do século XVIII, a Valáquia e a Moldávia se abriram para o Ocidente, e especialmente para a França, de onde o Iluminismo se espalhou por toda a Europa. Como resultado, uma série de laicos e religiosos traduzem escritos moralizantes e até científicos. O século seguinte representa um dos capítulos mais ricos da história da tradução romena. Foi na mesma época que os nomes das primeiras mulheres tradutoras foram registrados. No seu esforço para integrar a nossa cultura entre outras culturas importantes do continente, os tradutores tornam-se criadores de idioma e modelos literários e promotores de novas ideias na sociedade romena

Leczenie akromegalii w Rumunii. Jak blisko jesteśmy uzyskania kontroli nad chorobą?

Introduction: In Romania, no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral centre, which covers an important part of Romanian territory and population of patients with acromegaly. Materials and methods: We reviewed the records of all 164 patients (49 males and 115 females; median age 55 [47, 63.5] years) with newly or previously diagnosed acromegaly, who have been assessed at least once in our tertiary referral centre between January 1, 2012 and March 31, 2016. This sample represents 13.6% of the total expected 1200 Romanian patients with acromegaly and covers 82.9% of the counties in Romania. Control of acromegaly was defined as a random serum growth hormone (GH) < 1 ng/mL and an age-normalised serum insulin-like growth factor-I (IGF-I) value. The GH and IGF-I values used for calculation of the control rate were those at the last evaluation. The same assays for GH and IGF-I measurement were used in all patients. Results: There were 147 treated and 17 untreated patients. Of the 147 patients assessed after therapy, 137 (93.2%) had pituitary surgery, 116 (78.9%) were on medical treatment at the last evaluation, and 67 (45.5%) had radiotherapy. Seventy-one (48.3%) had a random GH < 1 ng/mL, 54 (36.7%) had a normalised, age-adjusted IGF-I, and 42 (28.6%) had both normal random serum GH and IGF-I. Conclusions: In Romania, acromegaly benefits from the whole spectrum of therapeutic interventions. However, the control rate remains disappointing.Wstęp: W Rumunii nie są dostępne ogólnokrajowe dane dotyczące leczenia akromegalii ani wskaźnika kontroli choroby. Badanie przeprowadzono w celu oceny wskaźnika kontroli akromegalii w ośrodku referencyjnym trzeciego stopnia, który obejmuje opieką zdrowotną znaczną część obszaru Rumunii i populacji pacjentów z akromegalią. Materiał i metody: Autorzy dokonali przeglądu danych medycznych wszystkich 164 chorych [49 mężczyzn i 115 kobiet; mediana wieku 55 lat (47; 63,5)] z noworozpoznaną lub wcześniej zdiagnozowaną akromegalią, których przynajmniej jednokrotnie zbadano w ośrodku referencyjnym trzeciego stopnia (miejsce pracy autorów) w okresie od 1 stycznia 2012 roku do 31 marca 2016 roku. Ta próba stanowiła 13,6% całej rumuńskiej populacji chorych na akromegalię szacowaną na 1200 osób i reprezentowała 82,9% okręgów administracyjnych w Rumunii. Kontrolę akromegalii definiowano jako stężenie przygodne hormonu wzrostu (growth hormone, GH) w surowicy wynoszące poniżej 1 ng/ml oraz normalizacja odpowiednio do wieku stężenia insulinopodobnego czynnika wzrostu 1 (insulin-like growth factor-1, IGF-1) w surowicy. Do obliczenia wskaźnika kontroli choroby stosowano wartości GH i IGF-1 z ostatnich pomiarów. U wszystkich pacjentów używano tych samych testów do pomiarów GH i IGF-1. Wyniki: Badanie obejmowało 147 chorych poddanych leczeniu i 17 chorych nieleczonych. Spośród 147 chorych ocenianych po terapii, u 137 (93,2%) zastosowano leczenie chirurgiczne, 116 (78,9%) w momencie ostatniej wizyty kontrolnej stosowało leczenie farmakologiczne, a 67 (45,5%) poddano radioterapii. U 71 chorych (48,3%) przygodne stężenie GH w surowicy wynosiło poniżej 1 ng/ml, u 54 (36,7%) uzyskano normalizację stężenia IGF-1 skorygowanego względem wieku, a u 42 chorych (28,6%) uzyskano normalizację obu parametrów — GH i IGF-1. Wnioski: W Rumunii u chorych na akromegalię stosuje się szerokie spektrum interwencji terapeutycznych, jednak wskaźnik kontroli choroby nadal pozostaje niezadawalający

High mortality risk among women with acromegaly still persists

IntroductionThe mortality ratio in patients with acromegaly has improved over the last few decades. We aimed to determine the mortality rate and correlated factors in patients with acromegaly before and after the introduction of national protocols for treatment. In addition, we determined whether there are sex-related differences in mortality of patients with acromegaly.MethodsThis observational retrospective study included 399 consecutive patients with acromegaly between January 2001–December 2022. Paraclinical data included random growth hormone (GH) and insulin-like growth factor-I (IGF1) levels, maximal pituitary tumor diameter at diagnosis, first visit, and last evaluation. Standardized mortality ratio (SMR) was calculated by dividing the observed and expected mortality rates. Cox regression analysis revealed the independent factors associated with mortality.ResultsAt the last visit, 31.07% (124) of patients were cured, 22.05% (88) had controlled acromegaly with medication, and 45.31% (181) had not controlled acromegaly. During follow-up (13.03 ± 5.65 years, 5216.62 person-years), 89 patients died (0.017%), resulting in an SMR of 1.18 [95% CI 0.95–1.45]. The independent factors associated with mortality were the last IGF1 level/last random GH level, absence of surgery, gonadotropin deficiency, and age. Patients with normal IGF1 after treatment showed an SMR of 0.71, whereas patients with IGF1 ratio > 1 showed SMR=1.51. Patients diagnosed between 1975–2007 and 2008–2022 had SMR = 1.25 [95% CI 0.97–1.58] and SMR = 1.09 [95% CI 0.68–1.65], respectively. In females with acromegaly, SMR was 1.63 [95% CI 1.24–2.11]; 1.76 [95% CI 1.30–2.34] in women diagnosed before 2008 and 1.33 [95% CI 0.69–2.33] in those diagnosed after 2008. Males with acromegaly had a mortality ratio similar to males from the general population (SMR = 0.99, [95% CI 0.66–1.41]).ConclusionPatients diagnosed with acromegaly in the last 15 years had lower mortality rates than those diagnosed before 2008, due to the availability of new medications, primarily somatostatin receptor analogs and to a higher proportion of patients undergoing surgery. Females still have a high mortality ratio owing to older age at diagnosis and higher risk of metabolic complications. Therefore, efforts should be made for early diagnosis of acromegaly in women

Improvement of acromegaly control with multimodal therapy in Romania

Introduction: In Romania, there is no acromegaly national register and there are no nationwide data available. However, some studies have reported the control rates in the country’s main referral centres. Our aim was to assess the overall control rate in our tertiary referral centre. Also, we assessed the control rate in the last three years, and we compared the results with our previous reports. Material and methods: We reviewed the charts of 186 patients with acromegaly assessed in our department between January 1st, 2012 and May 31st, 2019. We also compared the control rates for patients treated between April 1st, 2016 and May 31st, 2019 with historical controls (assessed between January 1st, 2012 and March 31st, 2016). Results: Primary analysis: There were 19 untreated and 167 treated patients, mean age 52.46 years, surgery being the most commonly used treatment. The surgical cure rate was 14.8%, and disease control with medical treatment was 35.3%. Secondary analysis: In the first group there were 45 patients, surgery also being the most commonly used treatment. The surgical cure rate was 26.9%, and disease control was 30.4%. In the second group (historical controls) there were 42 patients, surgery being the most commonly used treatment. The surgical cure rate was 9.7%, and disease control with medical treatment was 15.4%. Random GH and IGF-1 after surgery were lower in the first group (p < 0.05) Conclusions: Changes in the Romanian protocol and highly specialised pituitary centres has improved the cure rate and disease control in patients with acromegaly.

Oral Rehabilitation Therapies in A Patient with Facial Dysmorphia and Psychiatric Profile - Clinical Case Report

This article describes rehabilitation of one case, complex psychiatric treatment, facial asimetry, with mandibular and maxilla missing teeth and dental disharmony, with a fixed and also removable hybrid prosthesis. Rehabilitation with fixed or removable prosthesis is even more challenging when the edentulous span is long and the ridge is irregular deformities and unfavorable biomechanics encountered at the prosthetic field for complex rehabilitation.In such situation, a fixed-removable prosthesis allows favorable biomechanical stress distribution along with restoration of esthetics, phonetics, comfort, hygiene, and better postoperative care and maintenance</em

INFLUENCE OF FINISHING TECHNIQUES OF TI-BASED ALLOYS USED IN PROSTHETIC RESTORATIONS ON THE FORMATION OF CANDIDA ALBICANS BIOFILM

Surface roughness plays an important role in the formation of specific oral cavity biofilm. The paper aims at analyzing the influence of mechanical finishing techniques on the formation of Candida albicans biofilms. We studied two different Ti-based alloys used in prosthetic restorations and two finishing techniques: mechanical polishing with rubber polisher and mechanical polishing with cotton polisher and polishing paste. Examinations on roughness have made reference to Rz. The ability to adhere and to form the Candida albicans biofilms onto the rough surfaces of the studied samples was highlighted by scanning electron microscopy (SEM). Microbiological analysis indicates the strong relationship between the surface quality of dental alloys used in prosthetic restorations and the ability of the fungal pathogen of Candida albicans type to adhere to these metal surfaces

COMPARATIVE STUDY REGARDING THE MICRO-HARDNESS OF SOME AESTHETIC RESTORATIVE MATERIALS

Background In recent years and mainly after 2000, the trends in terms of the structure of dental composites have addressed the progressive decrease of filler particle size down to nanometric level. All these result from the need to continuously improve the properties of the composite material such as their hardness, mechanical resilience, contraction to polymerization and polymerization stress. The present study aimed to test the microhardness and to determine its variation in case of some coronary esthetic restorative materials commonly used in dental practice. Material and methods Experimental researches concerning the determination of the microhardness variations were performed on four direct dental restorative light-curing composite (Herculite XRV Ultra, Synergy D6 and Brilliant - nanohybrid composite and Latelux -microhybrid composite). Specimens, with a diameter of 10 × 10 mm and 4 mm thick, were developed in the Dental Materials laboratory of the Dental Medicine Faculty of "Gr. T. Popa " University of Medicine and Pharmacy of Iasi, in accordance with the manufacturer indications. Micro-hardness testing was performed in the Department of Material Engineering and Industrial Security of the Faculty of Materials Science and Engineering from “Gheorghe Asachi” Techncial University of Iaşi. Results Tests have revealed that direct composite resin Brilliant from Coltene Whaledent presents the highest values of Vickers micro-hardness. Conclusions For the selection and use of direct composite resins dentist must take into account the composition, clinical performance, handling characteristics and their biomechanical behavior, an important parameter being the micro-hardness