Xanthoma Disseminatum: Case Report

Xanthoma disseminatum is a rare, benign, non-Langerhans´ cell histiocytic disorder of unknown etiology. A case is presented of a 71-year-old man with a three- year his tory of disseminated symmetricyel low ish papules and plaques on the skin of the face, neck, flexor regions, trunk, extremities and oral mucosa, with fatty in filtration of the liver and pancreas, and cardiac complaints. Xanthomatous rhinophyma predominated on the face. Clinical, immunohistochemistry and histology findings indicated the diagnosis of xanthoma disseminatum. Although the patient had a positive family history of cardiovascular diseases and a number of symptoms that are often associated with hyperlipidemia, repeat plasma levels were always within the normal limits. The case was in teresting because of a number of etiologic factors that could be connected with the appearance of xanthomas in our patient. Therefore it was difficult to classify the disease into one of well-de fined nosologic entities. The case report is supplemented with a review of rele vant literature

Long-term Follow-up of a Case of Lymphomatoid Papulosis with a Benign Course

No abstract available

Zoon Plasma Cell Balanitis: An Over view and Role of Histopathology

Balanitis circumscripta plasmacellularis or Zoon?s balanitis is an idiopathic, benign condition of the genitalia that mostly presents as a solitary, persistent plaque on the glans of primarily uncircumcised, middle-aged to older men. Its etiology and pathogenesis remains speculative. This article provides an overview of the clinical morphology, microscopic features, differential diagnosis and therapy. Particular attention is paid to histopathologic features. Besides, a case is presented of an uncircumcised man with clinical and histologic features of balanitis circumscripta plasmacellularis who was success fully cured bycircumcision. The dis tinction of this lesion from similar lesions is rather im portant, and a large group of disorders such as premalignant, infective and other in flammatory penile diseases should be definitely taken intoconsideration on the differ ential diagnosis. It seems that circumcision might be the current ´gold standard´ for treatment of this disorder

Dermoscopy of Nodular Melanoma: Review of the Literature and Report of 3 Cases

Nodular melanoma is the most aggressive subtype of melanoma, with rapid growth rate and metastatic potential. It is usually diagnosed at a locally advanced stage (Breslow thickness &lt;2 mm) and is therefore associated with a poor prognosis. Nodular melanoma often does not fit the classic clinical ABCD criteria, but rather the EFG rule or 3 Cs criteria. Missing the diagnosis of nodular melanoma is a dermatologist’s worst nightmare, especially since nodular melanomas can have a non-alarming clinical appearance and imitate a wide range of benign lesions. All evolving nodular lesions, despite their size, symmetry, and color, which cannot be confidently diagnosed as benign, should be excised in order to rule out nodular melanoma. Almost all melanoma-specific dermoscopic criteria are described in context of superficial spreading melanoma. Thus, physicians are not familiar and aware enough of dermoscopic features for early detection of nodular melanomas. Herein we present 3 cases of nodular melanomas from our Department and give a review of the current literature.</p