Etude comparative et mise en oeuvre clinique de deux systèmes de radiothérapie asservie à la respiration

LE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Contrôle de qualité et mise en oeuvre d'un logiciel de planification inversé pour la radiothérapie conformationnelle avec modulation d'intensité

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

La radiothérapie conformationnelle (RT3D) du cancer du poumon (du volume tumoral macroscopique au volume traité)

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Utilisation d'un système d'imagerie portale électronique avec détecteur au silicium amorphe pour vérifier la dose reçue par les patients en radiothérapie

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

MODELISATION DE LA DISTRIBUTION DE DOSE EN PROTONTHERAPIE PAR SUPERPOSITION DE FAISCEAUX ELEMENTAIRES

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Radioprotection en scanographie chez l'enfant (évaluation et optimisation des doses délivrées lors des examens multicoupes, impact du contrôle automatique d'exposition et proposition de niveaux de référence diagnostiques pédiatriques)

LE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocSudocFranceF

MISE EN UVRE DE LA MODULATION D'INTENSITE PAR COLLIMATION DYNAMIQUE EN VUE D'UNE UTILISATION CLINIQUE EN RADIOTHERAPIE

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Quality assurance in conformal radiotherapy: DYNARAD consensus report on practice guidelines

Background and purpose: Conformal radiotherapy has only recently been widely implemented. Although not all aspects have yet been adequately proven, it is generally recognized that maintaining a high degree of precision throughout the process is critical to the treatment outcome while the focus for quality assurance and quality improvement will need to concentrate more on human factors, procedures, communication, organization and training. A general consensus document on quality assurance guidelines for institutions that deliver conformal radiotherapy treatments to patients has been elaborated within the framework of the DYNARAD/BIOMED concerted action on conformal radiotherapy. The present paper aims to highlight those issues that were identified as of specific importance to conformal radiotherapy. The work reported here further details this guidance by direct correlation with the issues involved in the special case of conformal radiotherapy. Methods: The DYNARAD document has been drafted in the form of a desktop guide comprising six sets of guidelines and is based on the ESTRO advisory report on 'Quality Assurance in Radiotherapy'. Results and conclusions: The document has been endorsed by the DYNARAD group of institutions. As such it can form the basis for further discussions and enter into the subsequent phase of expanding its consensus basis.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire.

International audienceThe human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-independent response, and gene-expression profiling of the different blood and splenic B-cell subsets, we show here that blood IgM(+)IgD(+)CD27(+) cells correspond to circulating splenic marginal zone B cells. Furthermore, analysis of this peripheral subset in healthy children younger than 2 years shows that these B cells develop and mutate their immunoglobulin receptor during ontogeny, prior to their differentiation into T-independent antigen-responsive cells. It is therefore proposed that these IgM(+)IgD(+)CD27(+) B cells provide the splenic marginal zone with a diversified and protective preimmune repertoire in charge of the responses against encapsulated bacteria