Research reports on the diagnosis and detection; environment and infection; and evaluation of interventions on infectious diseases.

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Chinese University of Hong Kong portfolio of basic, epidemiological, public health and clinical research on a diverse range of potentially emerging and re-emerging infectious diseases

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The University of Hong Kong portfolio of basic research on emerging infectious diseases

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Beyond sex allocation: the role of mating systems in sexual selection in parasitoid wasps

Despite the diverse array of mating systems and life histories which characterise the parasitic Hymenoptera,sexual selection and sexual conict in this taxon have been somewhat overlooked. For instance, parasitoidmating systems have typically been studied in terms of how mating structure affects sex allocation. In thepast decade, however, some studies have sought to address sexual selection in the parasitoid wasps moreexplicitly and found that, despite the lack of obvious secondary sexual traits, sexual selection has the potentialto shape a range of aspects of parasitoid reproductive behaviour and ecology. Moreover, various characteristicsfundamental to the parasitoid way of life may provide innovative new ways to investigate different processesof sexual selection. The overall aim of this review therefore is to re-examine parasitoid biology with sexualselection in mind, for both parasitoid biologists and also researchers interested in sexual selection and theevolution of mating systems more generally. We will consider aspects of particular relevance that have alreadybeen well studied including local mating structure, sex allocation and sperm depletion. We go on to review whatwe already know about sexual selection in the parasitoid wasps and highlight areas which may prove fruitfulfor further investigation. In particular, sperm depletion and the costs of inbreeding under chromosomal sexdetermination provide novel opportunities for testing the role of direct and indirect benets for the evolutionof mate choice

Senior Recital: Patrick Collins, trumpet and Junior Recital: Ra Sheed Lemon II, trumpet

This recital is presented in partial fulfillment of requirements for the degrees Bachelor of Music in Music Education and Bachelor of Music in Performance. Mr. Collins and Mr. Lemon study trumpet with Douglas Lindsey.https://digitalcommons.kennesaw.edu/musicprograms/2013/thumbnail.jp

Research fund for the control of infectious diseases: commissioned studies

Research Fund for the Control of Infectious Diseases: Research Dissemination Reportspublished_or_final_versio

Dermal fibroblasts from patients with Parkinson’s disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations

Background: Recently, the development of Parkinson’s disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. Methods: We investigated PD and Gaucher Disease (GD) patient derived skin fibroblasts using biochemistry assays. Results: PD patient derived skin fibroblasts have normal glucocerebrosidase (GCase) activity, whilst patients with PD and GBA mutations have a selective deficit in GCase enzyme activity and impaired autophagic flux. Conclusions: This data suggests that only PD patients with a GBA mutation have altered GCase activity and autophagy, which may explain their more rapid clinical progression.We are grateful to an NIHR award of a Biomedical Research Centre to Addenbrookes Hospital and the University of Cambridge. We are also grateful to the Rosetrees Trust, the WT-MRC Stem Cell Institute and the Canadian Institutes of Health Research (CIHR) fellowship (358492) for the funding for this work

Summary of research projects supported by the Health Services Research Fund (HSRF) and the Health Care and Promotion Fund (HCPF)

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