996 research outputs found

    Modern Wheat

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    The yields of wheat in the UK and across much of the world have increased massively over the past century, from a few tonnes per hectare at the start of the twentieth century to current UK average yields of between eight and nine tonnes per hectare. Many factors have contributed to these increases, with genetic improvement by plant breeding being particularly important in the second half of the 20th centur

    Analysis of mixed linkage Ī²-glucan content and structure in different wheat flour milling fractions

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    Ī²-glucan is a dietary fibre component with health benefits that relate to its structure and solubility. The polysaccharide structure consists predominantly of Ī²-(1ā€“4) linked cellotriosyl (G3) and cellotetraosyl (G4) units joined together with Ī²-(1,3) linkages. The ratio of G3:G4 blocks affects the solubility with very high or very low ratios causing lower solubility. Wheat, a major staple crop, is a source of Ī²-glucan in the human diet; however, there is a lack of research on Ī²-glucan in wheat, especially white flour which is used in many food products. Here we quantified Ī²-glucan in different wheat milling fractions, showing a low content in the first and second break (white) flour fractions (0.2%) with increasing amounts in bran flour (0.5%), wholemeal (0.8%) and bran (2.8%). A high proportion (30%) of Ī²-glucan in the white flour fractions was soluble, while in bran a far smaller proportion (10%) was soluble. In agreement with differences in solubility, the G3:G4 ratio also differed, with the white flour fractions having lower ratios (āˆ¼2.5) and bran-containing fractions having higher ratios (āˆ¼3.8). We conclude that while total Ī²-glucan in white flour is low, it is substantially soluble, and that high extraction and wholemeal flours have the potential to be a significant source of Ī²-glucan

    Role of Genetic Testing in Kidney Stone Disease: A Narrative Review

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    \ua9 The Author(s) 2024.Purpose of Review: Kidney stone disease (KSD) is a common and potentially life-threatening condition, and half of patients experience a repeat kidney stone episode within 5ā€“10 years. Despite the ~50% estimate heritability of KSD, international guidelines have not kept up with the pace of discovery of genetic causes of KSD. The European Association of Urology guidelines lists 7 genetic causes of KSD as ā€˜high riskā€™. Recent Findings: There are currently 46 known monogenic (single gene) causes of kidney stone disease, with evidence of association in a further 23 genes. There is also evidence for polygenic risk of developing KSD. Evidence is lacking for recurrent disease, and only one genome wide association study has investigated this phenomenon, identifying two associated genes (SLC34A1 and TRPV5). However, in the absence of other evidence, patients with genetic predisposition to KSD should be treated as ā€˜high riskā€™. Further studies are needed to characterize both monogenic and polygenic associations with recurrent disease, to allow for appropriate risk stratification. Durability of test result must be balanced against cost. This would enable retrospective analysis if no genetic cause was found initially. Summary: We recommend genetic testing using a gene panel for all children, adults < 25 years, and older patients who have factors associated with high risk disease within the context of a wider metabolic evaluation. Those with a genetic predisposition should be managed via a multi-disciplinary team approach including urologists, radiologists, nephrologists, clinical geneticists and chemical pathologists. This will enable appropriate follow-up, counselling and potentially prophylaxis

    Improving starch and fibre in wheat grain for humanĀ health

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    Reducing the prevalence of diet- related diseases, including obesity and type 2 diabetes, is a major challenge for health professionals, food manufacturers and governments in both developed and developing countries. Cereals are key targets in meeting this challenge as they are staple foods throughout the world and major sources of energy (derived principally from starch) and dietary fibre. Wheat is the staple cereal in the UK and Europe, and the UK Biotechnology and Biological Sciences Research Council (BBSRC)- supported Designing Future Wheat programme is focused on manipulating the content and composition of starch and fibre to improve health impacts, including reducing the glycaemic response and improving fermentation in the colon. This work is contributing to the development of improved cultivars by breeders and foods by processors. It is also increasing our understanding of the behaviour of these components in the human gastrointestinal (GI) tract and will contribute to the establishment of targets and recommendations for regulatory authorities

    Opinion Exploiting genomics to improve the benefits of wheat: Prospects and limitations

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    Conventional breeding has been immensely successful in increasing crop production to meet the demands of the growing global population, particularly for wheat where production has increased by over threefold over the last 60 years without a significant increase in the area of land used. However, the pace of improvement by conventional breeding is slow and limited by the range of variation present in wheat and species with which it can be crossed. Genomics can be defined as ā€œan interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomesā€ (Wikipedia). As such it has the potential to revolutionise crop improvement, by accelerating the rate of progress and increasing the range of variation that is available. Despite this potential, progress in the application of biotechnology to improve wheat has been slow, particularly when applied to the quality of the grain for processing and nutrition. We will therefore consider the reasons for this and identify priorities for future research
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