SUNLITE program. Sub-Hertz relative frequency stabilization of two diode laser pumped Nd:YAG lasers locked to a Fabry-Perot interferometer

Two laser pumped Nd:YAG lasers were frequency stabilized to a commercial 6.327 GHz free spectral range Fabry-Perot interferometer yielding a best case beatnote linewidth of 330 MHz. In addition, a Fabry-Perot interferometer with a free spectral range of 680 MHz, a linewidth of 25 kHz, and a finesse of 27,500 was built, and when it was substituted in place of the commercial interferometer, it produced a robust and easily repeatable beatnote linewidth of 700 MHz

High energy efficient solid state laser sources

Slab glass performance studies demonstate 18 J of output at 2 Hz with 2.3% wall plug efficiency. The goal is to achieve 10 J per pulse at 10 Hz and 3% wall plug efficiency during the next annual period. The slab concept was extended to Nd:YAG and to Nd:GGG. To date over 80 W of CW output power at 2% efficiency was generated in slab Nd:YAG. A multiplexed slab Nd:YAG pre-amplifier was invented and a Nd:YAG oscillator was demonstrated with 100kHz linewidth for eventual use in wind velocity measurements

Growth and evaluation of AgGaS2 and AgGaSe2 for infrared nonlinear applications

The crystal growth technology for the two chalcopyrite compounds AgGaS2 and AgGaSe2 was studied. These two materials demonstrated their promise as important nonlinear crystals for infrared applications ten years ago. However, at the time, a number of various growth related problems such as cracking, twinning and the occurrence of optical scattering centers made it difficult to obtain high quality specimens in sizes exceeding 1 cm. Using seeding and precision-tapered fused quartz growth ampoules, a Bridgman/Stockbarger growth technology was developed to grow crack and twin-free boules in increasingly larger dimensions with an ultimate goal of 4 cm crystals harvested obliquely from c-axis boules. The post-growth heat treatment procedures were studied to understand the solid state chemical reactions and to avoid crystal damage which frequently occurs during these annealing procedures

Infrared differential absorption for atmospheric pollutant detection

Progress made in the generation of tunable infrared radiation and its application to remote pollutant detection by the differential absorption method are summarized. It is recognized that future remote pollutant measurements depended critically on the availability of high energy tunable transmitters. Futhermore, due to eye safety requirements, the transmitted frequency must lie in the 1.4 micron to 13 micron infrared spectral range

Growth and evaluation of AgGaS2 and AgGaSe2 for infrared nonlinear applications

Significant advances were made in the growth technology of silver thiogallate (AgGaS2) and silver selenogallate (AgGaSe2). High efficiency harmonic generation of carbon dioxide laser radiation and tunable infrared parametric oscillation were demonstrated using these materials. Nonliner frequency conversion in the infrared was limited by the optical properties and the size of the available nonlinear materials. The development of these materials has reduced some of the limitations and generated wide interest. The continued development and application of AgGaS2 and AgGaSe2 now appears assured

Spatial and temporal filtering of a 10-W Nd:YAG laser with a Fabry-Perot ring-cavity premode cleaner

We report on the use of a fixed-spacer Fabry–Perot ring cavity to filter spatially and temporally a 10-W laser-diode-pumped Nd:YAG master-oscillator power amplifier. The spatial filtering leads to a 7.6-W TEMinfinity beam with 0.1% higher-order transverse mode content. The temporal filtering reduces the relative power fluctuations at 10 MHz to 2.8 x 10^-/sqrtHz, which is 1 dB above the shot-noise limit for 50 mA of detected photocurrent

Charge neutralization in vacuum for non-conducting and isolated objects using directed low-energy electron and ion beams

We propose using ions and electrons of energy 1 eV–10 eV for neutralizing the charges on the non-conducting or isolated surfaces of high-sensitivity experiments. The mirror surfaces of the test masses of the laser interferometer gravitational observatory are used as an example of the implementation of this method. By alternatively directing beams of positive and negative charges towards the mirror surfaces, we ensure the neutralization of the total charge as well as the equalization of the surface charge distribution to within a few eV of the potential of the ground reference of the vacuum system. This method is compatible with operation in high vacuum, does not require measuring the potential of the mirrors and is expected not to damage sensitive optical surfaces

Microstructure-based laser-driven free-electron laser

a b s t r a c t We propose an all-dielectric laser-driven undulator. This undulator consists of laser-driven deflection structures where the deflection force from the laser is phase-synchronous with the electron beam. This allows for an undulator period that is much greater than the laser wavelength. Due to the possibility of high peak electric fields from ultra-short pulse lasers on dielectric materials, the proposed undulator is expected to produce phase-synchronous GV/m deflection fields on a relativistic electron bunch and therefore lead to a very compact free-electron-based radiation device

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Although in vitro screens are essential for the initial identification of candidate therapeutic agents, a rigorous assessment of the drug's ability to inhibit tumor growth must be performed in a suitable animal model. The type of animal model that is best for this purpose is a topic of intense discussion. Some evidence indicates that preclinical trials examining drug effects on tumors arising in transgenic mice are more predictive of clinical outcome1and so candidate therapeutic agents are often tested in these models. Unfortunately, transgenic models are not available for many tumor types. Further, transgenic models often have other limitations such as concerns as to how well the mouse tumor models its human counterpart, incomplete penetrance of the tumor phenotype and an inability to predict when tumors will develop