Effect of therapeutic exercise on joint range and strength in throwing athletes with dyskinesia. A systematic review

El objetivo de este estudio fue determinar los efectos del ejercicio terapéutico (ET) sobre los cambios de rangos de movimiento (ROM) y la fuerza muscular (FM) en deportistas lanzadores que presentan disquinesia escapular (DE). Se realizó la búsqueda en Pubmed, Scopus, Web of Science, ScienceDirect de los últimos cinco años según la metodología PRISMA, considerando estudios que describieran los efectos de los programas de ejercicio terapéutico en rango articular y fuerza muscular de deportistas lanzadores. Se incluyeron un total de seis artículos relacionado con deportistas lanzadores con disquinesia escapular. Se encontraron resultados favorables dentro de las intervenciones que contaban con ET, el cual obtuvo un efecto significativo en las variables de ROM y fuerza muscular en deportistas lanzadores. En conclusión, los ejercicios de estiramientos terapéuticos son la herramienta más favorable y eficaz frente a cualquier otro tipo de intervención, teniendo un efecto sobre la FM y el ROM de los atletas lanzadores, ayudando así a su rendimiento competitivo.The aim of this study was to determine the effect of using therapeutic exercise (TE) on changes in the range of motion (ROM) and muscle strength (MS) in throwing athletes with scapular dyskinesis (SD).A systematic review was carried out in databases (Pubmed, Scopus, WoS, ScienceDirect) over the last five years, searching for randomized clinical trials, cohort studies, meta-analyses and concept reviews that met the inclusion, exclusion, and methodological quality criteria.A total of six articles related to throwing athletes with scapular dyskinesia were included. Favorable results were found within the interventions that included TE, which obtained a significant effect on the variables of ROM and muscle strength in throwing athletes.In conclusion,therapeutic stretching exercises are the most favorable and effective tool compared to any other type of intervention, having an effect on the MS and ROM of throwing athletes, thus helping their competitive performance

Efecto del ejercicio terapéutico sobre rango articular y fuerza muscular en deportistas lanzadores con disquinesia. Una revisión sistemática

The aim of this study was to determine the effect of using therapeutic exercise (TE) on changes in the range of motion (ROM) and muscle strength (MS) in throwing athletes with scapular dyskinesis (SD). A systematic review was carried out in databases (Pubmed, Scopus, WoS, ScienceDirect) over the last five years, searching for randomized clinical trials, cohort studies, meta-analyses and concept reviews that met the inclusion, exclusion, and methodological quality criteria. A total of six articles related to throwing athletes with scapular dyskinesia were included. Favorable results were found within the interventions that included TE, which obtained a significant effect on the variables of ROM and muscle strength in throwing athletes. In conclusion, therapeutic stretching exercises are the most favorable and effective tool compared to any other type of intervention, having an effect on the MS and ROM of throwing athletes, thus helping their competitive performance.El objetivo de este estudio fue determinar los efectos del ejercicio terapéutico (ET) sobre los cambios de rangos de movimiento (ROM) y la fuerza muscular (FM) en deportistas lanzadores que presentan disquinesia escapular (DE). Se realizó la búsqueda en Pubmed, Scopus, Web of Science, ScienceDirect de los últimos cinco años según la metodología PRISMA, considerando estudios que describieran los efectos de los programas de ejercicio terapéutico en rango articular y fuerza muscular de deportistas lanzadores. Se incluyeron un total de seis artículos relacionado con deportistas lanzadores con disquinesia escapular. Se encontraron resultados favorables dentro de las intervenciones que contaban con ET, el cual obtuvo un efecto significativo en las variables de ROM y fuerza muscular en deportistas lanzadores. En conclusión, los ejercicios de estiramientos terapéuticos son la herramienta más favorable y eficaz frente a cualquier otro tipo de intervención, teniendo un efecto sobre la FM y el ROM de los atletas lanzadores, ayudando así a su rendimiento competitivo

Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression

Immunoregulatory cytokine interleukin-10 (IL-10) is elevated in sera from patients with systemic lupus erythematosus (SLE) correlating with disease activity. The established association of IL10 with SLE and other autoimmune diseases led us to fine map causal variant(s) and to explore underlying mechanisms. We assessed 19 tag SNPs, covering the IL10 gene cluster including IL19, IL20 and IL24, for association with SLE in 15,533 case and control subjects from four ancestries. The previously reported IL10 variant, rs3024505 located at 1 kb downstream of IL10, exhibited the strongest association signal and was confirmed for association with SLE in European American (EA) (P = 2.7×10-8, OR = 1.30), but not in non-EA ancestries. SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls. Using nuclear extracts of peripheral blood cells from SLE patients for electrophoretic mobility shift assays, we identified specific binding of transcription factor Elk-1 to oligodeoxynucleotides containing the risk (G) allele of rs3122605, suggesting rs3122605 as the most likely causal variant regulating IL10 expression. Elk-1 is known to be activated by phosphorylation and nuclear localization to induce transcription. Of interest, phosphorylated Elk-1 (p-Elk-1) detected only in nuclear extracts of SLE PBMCs appeared to increase with disease activity. Co-expression levels of p-Elk-1 and IL-10 were elevated in SLE T, B cells and monocytes, associated with increased disease activity in SLE B cells, and were best downregulated by ERK inhibitor. Taken together, our data suggest that preferential binding of activated Elk-1 to the IL10 rs3122605-G allele upregulates IL10 expression and confers increased risk for SLE in European Americans.Peer Reviewe

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA

Objectives Systemic lupus erythematosus (SLE; OMIM 152700) is characterised by the production of antibodies to nuclear antigens. We previously identified variants in complement receptor 2 (CR2/CD21) that were associated with decreased risk of SLE. This study aimed to identify the causal variant for this association. Methods Genotyped and imputed genetic variants spanning CR2 were assessed for association with SLE in 15 750 case-control subjects from four ancestral groups. Allele-specific functional effects of associated variants were determined using quantitative real-time PCR, quantitative flow cytometry, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP)-PCR. Results The strongest association signal was detected at rs1876453 in intron 1 of CR2 (pmeta=4.2×10-4, OR 0.85), specifically when subjects were stratified based on the presence of dsDNA autoantibodies (case-control pmeta=7.6×10-7, OR 0.71; case-only pmeta=1.9×10-4, OR 0.75). Although allele-specific effects on B cell CR2 mRNA or protein levels were not identified, levels of complement receptor 1 (CR1/CD35) mRNA and protein were significantly higher on B cells of subjects harbouring the minor allele (p=0.0248 and p=0.0006, respectively). The minor allele altered the formation of several DNA protein complexes by EMSA, including one containing CCCTC-binding factor (CTCF), an effect that was confirmed by ChIP-PCR. Conclusions These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to lupus. Since the minor allele at rs1876453 is preferentially associated with reduced risk of the highly specific dsDNA autoantibodies that are present in preclinical, active and severe lupus, understanding its mechanisms will have important therapeutic implications

100 Cartas para Paulo Freire de quienes pretendemos Enseñar

Realizar un texto colectivo como “100 Cartas para Paule Freire de quienes pretendemos Enseñar”, es un desafío al reunir el aprehender desde el sentido profesional de la educación y con el espíritu de transformación, desde la educación como un espacio endógeno de revolución y exógeno a las comunidades y sociedades, en busca de un sentido de identidad. Hoy desde una crítica decolonial, antirracista, feminista y ecologica en la construcción de un sentido real que busque enfrentar el sistema hegemónico y destructivo que se ha impuesto con explotación, sangre y libertades de nuestro pueblo