Three-Component Domino Reactions for Selective Formation of Indeno[1,2‑<i>b</i>]indole Derivatives

Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-<i>b</i>]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds <b>6</b> with high <i>syn</i> diastereoselectivity. Both reactions showed attractive features including mild conditions, convenient one-pot operation, short reaction times of 15–32 min, and excellent regio- and/or stereoselectivity

Three-Component Domino Reactions for Selective Formation of Indeno[1,2‑<i>b</i>]indole Derivatives

Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-<i>b</i>]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds <b>6</b> with high <i>syn</i> diastereoselectivity. Both reactions showed attractive features including mild conditions, convenient one-pot operation, short reaction times of 15–32 min, and excellent regio- and/or stereoselectivity

Three-Component Domino Reactions for Selective Formation of Indeno[1,2‑<i>b</i>]indole Derivatives

Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-<i>b</i>]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds <b>6</b> with high <i>syn</i> diastereoselectivity. Both reactions showed attractive features including mild conditions, convenient one-pot operation, short reaction times of 15–32 min, and excellent regio- and/or stereoselectivity

Three-Component Domino Reactions for Selective Formation of Indeno[1,2‑<i>b</i>]indole Derivatives

Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-<i>b</i>]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds <b>6</b> with high <i>syn</i> diastereoselectivity. Both reactions showed attractive features including mild conditions, convenient one-pot operation, short reaction times of 15–32 min, and excellent regio- and/or stereoselectivity

Written on the Floor: Shared Theatre Space as Palimpsest

Efficient domino approaches for the synthesis of multifunctionalized tricyclic fused pyrroles and dibenzo[<i>b</i>,<i>e</i>][1,4]diazepin-1-ones have been established. The reaction pathways were controlled by varying enaminones with different substituted patterns to give a series of new fused pyrroles and dibenzo[<i>b</i>,<i>e</i>][1,4]diazepin-1-ones selectively. The complete <i>anti</i> diastereoselectivity was achieved for the first reaction