25 research outputs found
Mechanical Reinforcement in Thermoplastic Polyurethane Nanocomposite Incorporated with Polydopamine Functionalized Graphene Nanoplatelet
Thermoplastic
polyurethane (TPU) nanocomposites incorporated with
polydopamine functionalized graphene nanoplatelet (PDA-GNP) were prepared
by in situ polymerization. Fourier transform infrared spectroscopy
results indicated that the addition of PDA-GNP could promote the formation
of hydrogen bonding and microphase separation. The microstructure
obtained from small-angle neutron scattering indicated that the addition
of PDA-GNP increased the number while significantly it decreased the
size of hard microdomains. Scanning electron microscopy demonstrated
that PDA-GNP exhibited strong interfacial interactions with TPU matrix.
In particular, the tensile strength, strain at break, and toughness
of TPU/PDA-GNP with as low as 0.5 wt % PDA-GNP increased by 313, 16,
and 279%, respectively. This individualized phenomenon was attributed
to the abundant covalent bonding between PDA-GNP and TPU resulting
in strong interfacial interactions and good compatibility specifically
associated with the changes of TPU microstructure
The Study of an Alcoholysis Reaction of Silicon Tetrafluoride with Alcohols and Magnesium to Prepare Tetraalkoxysilanes and Magnesium Fluoride
<div><p>GRAPHICAL ABSTRACT</p><p></p></div
Could the Extent of Lymphadenectomy Be Modified by Neoadjuvant Chemotherapy in Cervical Cancer? A Large-Scale Retrospective Study
<div><p>Background</p><p>The effect of neoadjuvant chemotherapy (NACT) on topographical distribution patterns of lymph node metastasis in cervical cancer was unknown.</p><p>Methods</p><p>Patients with FIGO stage IB1-IIB who underwent radical surgery with or without NACT were enrolled (3527 patients). A matched-case comparison design was used to compare the effects of NACT on lymph node metastasis.</p><p>Results</p><p>We analyzed groups of 167 and 140 patients who were diagnosed with lymph node metastasis in the matched primary surgery group and NACT group, respectively, and no significant difference was observed (p = 0.081). The incidence of lymph node metastasis was significantly decreased in the NACT-responsive group compared to the non-responsive group (18.4% vs. 38.6%, P<0.001). The metastatic rates for every lymph node group also declined in the NACT-responsive group except for the deep inguinal and the para-aortic lymph node groups. Clinical response, deep stromal, parametrial and lymph vascular invasions were independent risk factors for lymph node metastasis in the NACT group. Furthermore, deep stromal invasion and lymph vascular invasion, but not the response to NACT, were independently associated with upper LNM. The number of lymph nodes involved, response to NACT, tumor histology and a positive vaginal margin were independent prognostic factors affecting DFS or OS rates in node-positive patients treated with NACT plus radical surgery.</p><p>Conclusion</p><p>The frequency and topographic distribution of LNM are not modified by NACT, and clinical non-responders showed more involved LNs. A systemic and extensive lymphadenectomy should be performed in patients treated with NACT plus surgery regardless of the response to NACT.</p></div
Overall survival and disease-free survival of patients in the primary NACT group by the number of lymph nodes involved (A, B) and the number of lymph node groups involved (C, D).
<p>Overall survival and disease-free survival of patients in the primary NACT group by the number of lymph nodes involved (A, B) and the number of lymph node groups involved (C, D).</p
Identified glycosyl transferases and hydrolases by the shotgun glycopeptide capture approach.
<p>Identified glycosyl transferases and hydrolases by the shotgun glycopeptide capture approach.</p
Multivariate analyses of risk factors for lymph node metastasis and upper lymph node metastasis in patients who had received NACT.
<p>Multivariate analyses of risk factors for lymph node metastasis and upper lymph node metastasis in patients who had received NACT.</p
Comparison of incidence and distribution of LNM between the matched NACT and PST group (A-B), clinical responders and clinical non-responders (C-D).
<p>Comparison of incidence and distribution of LNM between the matched NACT and PST group (A-B), clinical responders and clinical non-responders (C-D).</p
Overall survival and disease-free survival of patients in the primary NACT group by the site of lymph nodes involved.
<p>(A-B) negative lymph nodes, lower and upper positive lymph nodes; (C-D) negative lymph nodes, unilateral and bilateral positive lymph nodes.</p
Comparison of incidence of LNM between matched NACT group and PST group, primary NACT group with clinical response and with clinical non-response, respectively, stratified by tumor size, FIGO stage, and histology.
<p>Comparison of incidence of LNM between matched NACT group and PST group, primary NACT group with clinical response and with clinical non-response, respectively, stratified by tumor size, FIGO stage, and histology.</p
Comparison of N-glycoproteome and cell-surface membrane proteome in the identification of ES-cell surface markers.
<p>A) Comparison between our N-glycoproteome (E14Glyco), the curated known ES and the somatic stem-cell markers. B) Comparison between cell-surface membrane proteome (D3) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055722#pone.0055722-Wollscheid1" target="_blank">[22]</a> and the same stem-cell marker sets.</p