5 research outputs found
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The Mitochondrial DNA Af nities of the Prehistoric People of San Clemente Island: An Analysis of Ancient DNA
Native American mitochondrial DNA belongs to one of ve haplogroups de ned by lineage-speci c markers. Haplogroup frequency distribution is non-random among cultures. At historical contact, the Gabrielino occupied the southernmost California Channel Islands and the adjacent Los Angeles Basin. The Chumash thrived on the northern Channel Islands and Santa Barbara mainland. The Gabrielino were linguistically, culturally, and possibly genetically distinct from the Chumash. Haplogroup frequencies were determined for two prehistoric populations from San Clemente Island (Eel Point and the Nursery Site) to investigate Uto-Aztecan migration onto the southern Channel Islands. Analysis included three measures of genetic distance and phylogenetic analysis, as well as Fisher’s exact tests. The Eel Point and Nursery Site frequency distributions were compared to one another, and to extant Uto-Aztecan and Great Basin/California populations. Results suggest that the prehistoric occupants of Eel Point and the Nursery Site were not closely related to one another or to the Chumash
Differential expression of microRNA-320a, -145, and -192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum
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Ancient human parallel lineages within North America contributed to a coastal expansion.
Little is known regarding the first people to enter the Americas and their genetic legacy. Genomic analysis of the oldest human remains from the Americas showed a direct relationship between a Clovis-related ancestral population and all modern Central and South Americans as well as a deep split separating them from North Americans in Canada. We present 91 ancient human genomes from California and Southwestern Ontario and demonstrate the existence of two distinct ancestries in North America, which possibly split south of the ice sheets. A contribution from both of these ancestral populations is found in all modern Central and South Americans. The proportions of these two ancestries in ancient and modern populations are consistent with a coastal dispersal and multiple admixture events
Ancient human parallel lineages within North America contributed to a coastal expansion.
Little is known regarding the first people to enter the Americas and their genetic legacy. Genomic analysis of the oldest human remains from the Americas showed a direct relationship between a Clovis-related ancestral population and all modern Central and South Americans as well as a deep split separating them from North Americans in Canada. We present 91 ancient human genomes from California and Southwestern Ontario and demonstrate the existence of two distinct ancestries in North America, which possibly split south of the ice sheets. A contribution from both of these ancestral populations is found in all modern Central and South Americans. The proportions of these two ancestries in ancient and modern populations are consistent with a coastal dispersal and multiple admixture events