Digitisation and 3D reconstruction of 30 year old microscopic sections of human embryo, foetus and orbit

A collection of 2200 microscopic sections was recently recovered at the Netherlands Ophthalmic Research Institute and the Department of Anatomy and Embryology of the Academic Medical Centre in Amsterdam. The sections were created thirty years ago and constitute the largest and most detailed study of human orbital anatomy to date. In order to preserve the collection, it was digitised. This paper documents a practical approach to the automatic reconstruction of a 3- D representation of the original objects from the digitised sections. To illustrate the results of our approach, we show a multi-planar reconstruction and a 3-D direct volume rendering of a reconstructed foetal head

Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro

In a substantial part of adrenal adenomas and hyperplasias from patients with Cushing's syndrome, cortisol production is controlled by the expression of aberrant hormone receptors on adrenocortical cells. We present in vivo and in vitro data of two patients with a LH-responsive Cushing's syndrome based on ACTH-independent bilateral adrenal hyperplasia. Patients 1 and 2 are women who presented with Cushing's syndrome and bilateral adrenal hyperplasia. Endocrine testing demonstrated absence of cortisol diurnal rhythm, insufficient cortisol suppression after 1 mg dexamethasone orally, and undetectable ACTH levels in both patients. Both patients were treated by laparoscopic biadrenalectomy. In in vivo testing, in patients 1 and 2, a profound cortisol rise was found after administration of GnRH [change in cortisol (Delta F), 118 and 106%, respectively], human CG (Delta F, 133 and 44%), LH (Delta F, 73 and 43%), ACTH (Delta F, 89 and 181%), and the 5-hydroxy-tryptamine receptor type 4 (5-HT(4)) agonists cisapride (Delta F, 141 and 148%) and metoclopramide (Delta F, 189 and 95%). In in vitro testing, adrenal cells from patient 2 responded, in a dose-dependent fashion, with cortisol production after exposure to human CG (Delta F, 45%), cisapride (Delta F, 68%), and metoclopramide (Delta F, 81%). ACTH induced cortisol production by cells from both patients (Delta F, 135 and 159%). In receptor studies, LH receptor mRNA was demonstrated in adrenal tissue of both patients but also in control adrenal tissue of two patients with persisting pituitary-dependent Cushing's syndrome treated by biadrenalectomy. In neither patient were mutations found in the ACTH receptor gene. LH-responsive Cushing's syndrome associated with bilateral adrenal hyperplasia may result from aberrant (or possibly increased) adrenal LH receptor expression. This variant is further characterized by adrenal responsiveness to 5-HT4 receptor agonists, po

Financial analysis of the Company and Suggestions for its Improvement

Bakalárska práca je zameraná na zhodnotenie doterajšieho ekonomického vývoja podniku pomocou finančnej analýzy v období 2014 – 2018. Prvá časť bakalárskej práce sa zaoberá teoretickými poznatkami. V druhej časti práce je predstavená charakteristika spoločnosti, výpočty ukazovateľov a zhodnotenie finančnej situácie na základe výsledkov analýz. Záverečná časť je venovaná návrhom, vďaka ktorým je možné dosiahnuť zlepšenie spoločnosti.The bachelor thesis is focused on the evaluation of the present economic business development through financial analysis in years 2014 to 2018. In the first part of the bachelor thesis there are theoretical notes. In the second part there are introduced characteristic of society, calculations of indicators and evaluation of financial situation based on the results of the analysis. The last part concern recommendation, which lead to improvements of investigated status.

Research issues in vector and tensor field visualization

Today, computational fluid dynamics (CFD) research is almost impossible without computer-generated visualizations of the very large amounts of data resulting from numerical simulations. Although good techniques now exist for analysis of scalar data, most existing techniques for the visualization of vector fields-the predominant data type in CFD-meet only part of what is required. Common techniques such as arrow plots, streamlines, and particles work well for 2D applications, but for 3D data sets they often lead to cluttered displays. For tensors, which are much more complex and abstract entities the problem is even more severe. There is a real need for visualization, but there are no simple solutions. Many researchers have recognized this challenge and developed new techniques. We restrict ourselves to open research issues. We proceed in three ways. First, we propose a classification of existing vector and tensor field visualization techniques based on work by Delmarcelle and Hesselink (1994) and point out research gaps in this classification scheme. Second, we discuss feature-based visualization, which shows higher level descriptions derived from elementary data. Third, we consider the role of visualization in the research process, again revealing gaps in our current know-how concerning visualization of vector and tensor fields