Representative MPG western blot assays of an RA patient and a control patient.

<p>Representative MPG western blot assays of an RA patient and a control patient.</p

Distribution of MPG copy number variation (CNV) in RA patients (n = 235) and controls (n = 223).

<p>Distribution of MPG copy number variation (CNV) in RA patients (n = 235) and controls (n = 223).</p

Genotype and allele frequencies of MPG genetic polymorphisms in RA patients (n = 365) and controls (n = 375).

<p>Genotype and allele frequencies of MPG genetic polymorphisms in RA patients (n = 365) and controls (n = 375).</p

Serum level of MPG protein in RA patients (n = 40) and controls (n = 39).

<p>Serum level of MPG protein in RA patients (n = 40) and controls (n = 39).</p

Relationships between MPG-3644 (rs2858056) genotype and clinical signs and findings in patients with RA.

<p>Relationships between MPG-3644 (rs2858056) genotype and clinical signs and findings in patients with RA.</p

Additional file 1: of Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-ÎşB and mitogen-activated protein kinase pathways

Figure S1. Representative base peak chromatograms of aqueous extract of RPR positive (A) and negative (B) ion modes obtained from Bruker HCT Ultra Ion Trap MS spectrometer. Detailed experimental conditions were shown in the text. (PDF 10 kb

Additional file 2: of Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-ÎşB and mitogen-activated protein kinase pathways

Figure S2. Chemical structures of the major components identified from the aqueous extract of Radix Paeoniae Rubra. (PDF 7 kb