Competing feedback in an idealized tide-influenced delta network

The morphodynamic evolution of river deltas is intimately tied to flow and sediment partitioning at bifurcations. In this work, the long-term equilibrium configuration of a simple delta network is investigated by means of an analytical model, which accounts for the effect of small tidal oscillations. Differently from individual bifurcations where tidal action is always a stabilizing factor, in the case of a tree-like delta with multiple bifurcations a dual response emerges. Specifically, depending on the values of four reference parameters functions of tidal amplitude, upstream flow conditions, and channels geometry, tides can either promote or discourage an unbalanced discharge distribution. This behavior primarily concerns the apex bifurcation, which is affected by the variations of the relative tidal amplitude at the internal nodes. In turn these variations depend on how flow and sediment are diverted upstream. The stability of steady-state solutions is found to be governed by the sign and magnitude of the slope asymmetry between channels. This work provides a basic modeling framework for the interpretation of the autogenic response of multiple coupled micro-tidal bifurcations, which can potentially be extended to include in a unified scheme erosional and depositional processes typical of fluvio-deltaic systems

The 3Rs: reduction and refinement through a multivariate statistical analysis approach in a behavioural study to unveil anxiolytic effects of natural extracts of Tilia Tomentosa.

Proceedings of the second Centro 3R Annual Meeting - Young Scientists | June 20-21, 2019, Genoa (Italy

Use of an animal model to evaluate anxiolytic effects of dietary supplementation with tilia tomentosa moench bud extracts

Anxiety disorders are common and complex psychiatric syndromes affecting a broad spectrum of patients. On top of that, we know that aging produces an increase in anxiety vulnerability and sedative consumption. Moreover, stress disorders frequently show a clear gender susceptibility. Currently, the approved pharmacological strategies have severe side effects such as hallucinations, addiction, suicide, insomnia, and loss of motor coordination. Dietary integration with supplements represents an intriguing strategy for improving the efficacy and the safety of synthetic anxiolytics. Accordingly, a recent article demonstrated that glyceric bud extracts from Tilia tomentosa Moench (TTBEs) exert effects that are consistent with anxiolytic activity. However, the effects of these compounds in vivo are unknown. To examine this question, we conducted behavioral analysis in mice. A total of 21 days of oral supplements (vehicle and TTBEs) were assessed by Light Dark and Hole Board tests in male and female mice (young, 3 months; old, 24 months). Interestingly, the principal component analysis revealed gender and age-specific behavioral modulations. Moreover, the diet integration with the botanicals did not modify the body weight gain and the daily intake of water. Our results support the use of TTBEs as dietary supplements for anxiolytic purposes and unveil age and gender-dependent responses

Amenazas de depósitos de laderas en ambientes áridos. La revegetación como acción preventiva (Bromeliaceae - Deuterocohnia longipetala (Baker) Mez.)

Se efectuó un estudio de los subsistemas físico y biótico, en la región central de la vertiente occidental de la PrecordilleraOriental, para reconocer amenazas potenciales de aluviones o debris flow, mediante el análisis de lóbulos o depósitos deabanicos aluviales y poder brindar medidas preventivas de control mediante la dispersión de vegetación nativa. El análisisgeomorfológico muestra numerosos depósitos con distintos tipos de dinámicas y en diferentes posiciones topográficas,correspondientes a distintos ciclos sedimentarios acontecidos durante el Cenozoico tardío. La vegetación relevada contieneespecies y coberturas vegetales diferentes en los depósitos fanglomerádicos, destacándose el predominio de Deuterocohnialongipetala (Baker- Mez.). Los depósitos de canales actuales y activos tienen un predominio de Bulnesia retama y Larreadivaricata mientras que los inactivos tienen un dominio de chaguares (Deuterocohnia longipetala). Se recomienda ladispersión y revegetación en los lóbulos semiactivos con la planta citada en último término por su alta resistencia a lascondiciones xéricas y buena capacidad de fijación y formación de suelos

Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data

Romidepsin is an epigenetic agent approved for the treatment of patients with cutaneous or peripheral T-cell lymphoma (CTCL and PTCL). Here we report data in all patients treated on the National Cancer Institute 1312 trial, demonstrating long-term disease control and the ability to retreat patients relapsing off-therapy. In all, 84 patients with CTCL and 47 with PTCL were enrolled. Responses occurred early, were clinically meaningful and of very long duration in some cases. Notably, patients with PTCL receiving romidepsin as third-line therapy or later had a comparable response rate (32%) of similar duration as the total population (38%). Eight patients had treatment breaks of 35months to 10years; in four of six patients, re-initiation of treatment led to clear benefit. Safety data show slightly greater haematological and constitutional toxicity in PTCL. cDNA microarray studies show unique individual gene expression profiles, minimal overlap between patients, and both induction and repression of gene expression that reversed within 24h. These data argue against cell death occurring as a result of an epigenetics-mediated gene induction programme. Together this work supports the safety and activity of romidepsin in T-cell lymphoma, but suggests a complex mechanism of action