Simulation System for the Wendelstein 7-X Safety Control System

The Wendelstein 7-X (W7-X) Safety Instrumented System (SIS) ensures personal safety and investment protection. The development and implementation of the SIS are based on the international safety standard for the process industry sector, IEC 61511. The SIS exhibits a distributed and hierarchical organized architecture consisting of a central Safety System (cSS) on the top and many local Safety Systems (lSS) at the bottom. Each technical component or diagnostic system potentially hazardous for the staff or for the device is equipped with an lSS. The cSS is part of the central control system of W7-X. Whereas the lSSs are responsible for the safety of each individual component, the cSS ensures safety of the whole W7-X device. For every operation phase of the W7-X experiment hard- and software updates for the SIS are mandatory. New components with additional lSS functionality and additional safety signals have to be integrated. Already established safety functions must be adapted and new safety functions have to be integrated into the cSS. Finally, the safety programs of the central and local safety systems have to be verified for every development stage and validated against the safety requirement specification. This contribution focuses on the application of a model based simulation system for the whole SIS of W7-X. A brief introduction into the development process of the SIS and its technical realization will be give followed by a description of the design and implementation of the SIS simulation system using the framework SIMIT (Siemens). Finally, first application experiences of this simulation system for the preparation of the SIS for the upcoming operation phase OP 1.2b of W7-X will be discussed

Condom Use Trajectories in Adolescence and the Transition to Adulthood: The Role of Mother and Father Support

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92028/1/jora775.pd

Collinear helium under periodic driving: stabilization of the asymmetric stretch orbit

The collinear eZe configuration of helium, with the electrons on opposite sides of the nucleus, is studied in the presence of an external electromagnetic (laser or microwave) field. We show that the classically unstable "asymmetric stretch" orbit, on which doubly excited intrashell states of helium with maximum interelectronic angle are anchored, can be stabilized by means of a resonant driving where the frequency of the electromagnetic field equals the frequency of Kepler-like oscillations along the orbit. A static magnetic field, oriented parallel to the oscillating electric field of the driving, can be used to enforce the stability of the configuration with respect to deviations from collinearity. Quantum Floquet calculations within a collinear model of the driven two-electron atom reveal the existence of nondispersive wave packets localized on the stabilized asymmetric stretch orbit, for double excitations corresponding to principal quantum numbers of the order of N > 10.Comment: 13 pages, 12 figure

Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis

Juvenile dermatomyositis (JDM) is a pediatric autoimmune disease associated with characteristic rash and proximal muscle weakness. To gain insight into differential lymphocyte gene expression in JDM, peripheral blood mononuclear cells from 4 new-onset JDM patients and 4 healthy controls were sorted into highly enriched lymphocyte populations for RNAseq analysis. NK cells from JDM patients had substantially greater differentially expressed genes (273) than T (57) and B (33) cells. Upregulated genes were associated with the innate immune response and cell cycle, while downregulated genes were associated with decreased ribosomal RNA. Suppressed ribosomal RNA in JDM NK cells was validated by measuring transcription and phosphorylation levels. We confirmed a population of low ribosome expressing NK cells in healthy adults and children. This population of low ribosome NK cells was substantially expanded in 6 treatment-naïve JDM patients and was associated with decreased NK cell degranulation. The enrichment of this NK low ribosome population was completely abrogated in JDM patients with quiescent disease. Together, these data suggest NK cells are highly activated in new-onset JDM patients with an increased population of low ribosome expressing NK cells, which correlates with decreased NK cell function and resolved with control of active disease

Analysing Lyapunov spectra of chaotic dynamical systems

It is shown that the asymptotic spectra of finite-time Lyapunov exponents of a variety of fully chaotic dynamical systems can be understood in terms of a statistical analysis. Using random matrix theory we derive numerical and in particular analytical results which provide insights into the overall behaviour of the Lyapunov exponents particularly for strange attractors. The corresponding distributions for the unstable periodic orbits are investigated for comparison.Comment: 4 pages, 4 figure

Dysregulated NK cell PLCγ2 signaling and activity in juvenile dermatomyositis

Juvenile dermatomyositis (JDM) is a debilitating pediatric autoimmune disease manifesting with characteristic rash and muscle weakness. To delineate signaling abnormalities in JDM, mass cytometry was performed with PBMCs from treatment-naive JDM patients and controls. NK cell percentages were lower while frequencies of naive B cells and naive CD4+ T cells were higher in JDM patients than in controls. These cell frequency differences were attenuated with cessation of active disease. A large number of signaling differences were identified in treatment-naive JDM patients compared with controls. Classification models incorporating feature selection demonstrated that differences in phospholipase Cγ2 (PLCγ2) phosphorylation comprised 10 of 12 features (i.e., phosphoprotein in a specific immune cell subset) distinguishing the 2 groups. Because NK cells represented 5 of these 12 features, further studies focused on the PLCγ2 pathway in NK cells, which is responsible for stimulating calcium flux and cytotoxic granule movement. No differences were detected in upstream signaling or total PLCγ2 protein levels. Hypophosphorylation of PLCγ2 and downstream mitogen-activated protein kinase-activated protein kinase 2 were partially attenuated with cessation of active disease. PLCγ2 hypophosphorylation in treatment-naive JDM patients resulted in decreased calcium flux. The identification of dysregulation of PLCγ2 phosphorylation and decreased calcium flux in NK cells provides potential mechanistic insight into JDM pathogenesis

A Census of the Extended Neutral Hydrogen around 18 MHONGOOSE Galaxies

We present the analysis of the diffuse, low column density H I environment of 18 MHONGOOSE galaxies. We obtained deep observations with the Robert C. Byrd Green Bank Telescope and reached down to a 3σ column density detection limit of NHI = 6.3 × 1017 cm-2 over a 20 km s-1 line width. We analyze the environment around these galaxies, with a focus on H I gas that reaches column densities below NHI = 1019 cm-2. We calculate the total amount of H I gas in and around the galaxies, revealing that nearly all of these galaxies contained excess H I outside of their disks. We quantify the amount of diffuse gas in the maps of each galaxy, defined by H I gas with column densities below 1019 cm-2, and find a large spread in percentages of diffuse gas. However, by binning the percentage of diffuse H I into quarters, we find that the bin with the largest number of galaxies is the lowest quartile (0%-25% diffuse H I). We identified several galaxies that may be undergoing gas accretion onto the galaxy disk using multiple methods of analysis, including azimuthally averaging column densities beyond the disk, and identifying structure within our integrated intensity (moment 0) maps. We measured H I mass outside the disks of most of our galaxies, with rising cumulative flux even at large radii. We also find a strong correlation between the fraction of diffuse gas in a galaxy and its baryonic mass, and we test this correlation using both Spearman and Pearson correlation coefficients. We see evidence of a dark matter halo mass threshold of Mhalo ∼ 1011.1 M⊙ in which galaxies with high fractions of diffuse H I all reside below. It is in this regime that cold-mode accretion should dominate. Finally, we suggest a rotation velocity of vrot ∼ 80 km s-1 as an upper threshold to find diffuse-gas-dominated galaxies