第809回千葉医学会例会・第一外科教室談話会 64.

<p>RR, relative risk.</p

Examples of online research initiatives.

<p>Quoted information was downloaded from the organizations' websites on July 1, 2012.</p>a<p>Beta version.</p>b<p>Acquired by 23andMe.</p

Recommendations for communicating opportunities and limitations of research conducted using data obtained through online communities.

<p>Recommendations for communicating opportunities and limitations of research conducted using data obtained through online communities.</p

Biases in observational studies and their potential effect when using self-report data from self-selected individuals [12].

<p>Biases in observational studies and their potential effect when using self-report data from self-selected individuals <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001328#pmed.1001328-DelgadoRodrguez1" target="_blank">[12]</a>.</p

Additional file 1: of Reclassification of genetic-based risk predictions as GWAS data accumulate

The following additional data are available with the online version of this paper. Table S1a. Reclassification results for BrCa. Table S1b. Reclassification in cases for BrCa. Table S2aa Reclassification results for CHD. Table S2b. Reclassification in cases for CHD. Table S3a. Reclassification results for T2D. Table S3b. Reclassification in cases for T2D. Table S4a. Reclassification results for PrCa. Table S4b. Reclassification for cases for PrCa. Table S5. Proportion of Higher Risk individuals reclassified from Higher Risk to Lower Risk categories. Table S6. Reclassification in cases when sample size doubled. (DOCX 24 kb

Baseline characteristics of patients with acute ischemic stroke/transient ischemic attack.

<p>Baseline characteristics of patients with acute ischemic stroke/transient ischemic attack.</p

Number of GPIb and GPIIb/IIIa receptors in patients with acute ischemic stroke/transient ischemic attack, as well as patients with chronic cerebrovascular disease and healthy volunteers by univariate and multivariate analysis.

<p>Number of GPIb and GPIIb/IIIa receptors in patients with acute ischemic stroke/transient ischemic attack, as well as patients with chronic cerebrovascular disease and healthy volunteers by univariate and multivariate analysis.</p

Predictors of GPIb and GPIIb/IIIa receptor numbers in patients with acute ischemic stroke/transient ischemic attack by multivariate analysis.

<p>Predictors of GPIb and GPIIb/IIIa receptor numbers in patients with acute ischemic stroke/transient ischemic attack by multivariate analysis.</p

A genome-wide association study of energy intake and expenditure - Fig 2

<p>A) QQ plot for the SNP effect on daily energy expenditure for lean women and men. B) Manhattan plot for the SNP effect on daily energy expenditure for lean women and men. C) LocusZoom plot of the region associated with daily energy expenditure for lean women and men on chromosome 2q22.1.</p

TAFI deficiency does not improve outcome after experimental stroke in mice.

<p>Infarct size and functional outcome in <i>TAFI^-/-</i> mice and controls (WT, wild-type) 24h after 60 min transient middle cerebral artery occlusion (tMCAO). (A) (top) Representative 2,3,5-Triphenyltetrazoliumchloride (TTC)-stained coronal brain sections from the two animal groups. Ischemic infarctions appear white and regularly include the neocortex and basal ganglia as confirmed by hematoxylin and eosin (H&E) staining (bar represents 250 µm, dotted white line indicates the border between the cortex and the basal ganglia). (bottom) Infarct volumes on day 1 after tMCAO in <i>TAFI^-/-</i> mice and controls as determined by planimetry (n = 11–12/group). Non-parametric Mann Whitney test. (B) Neurological Bederson score and grip test score on day 1 after tMCAO in <i>TAFI^-/-</i> mice and controls. In line with the results on infarct volumes, no significant functional differences became apparent. Non-parametric Mann Whitney test (C) Accumulation of fibrin(ogen) in the infarcted (+) and contralateral (−) cortices of <i>TAFI^-/-</i> mice and controls. Fibrin(ogen) was analyzed by immunoblotting 24 h after ischemia. Two representative immunoblots of each group are shown.</p