MNWS and ZSDS scores and CO levels of the three phenotypic clusters (C1, C2, C3) identified by two-step cluster analysis.

<p>MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale; SD, standard deviation.</p

Linkage disequilibrium map of the seven investigated SNPs.

<p>1 = rs4522666, 2 = rs6090378, 3 = rs3787138; 4 = rs1044396; 5 = rs3787140, 6 = rs2093107, 7 = rs755203.</p

Descriptive characteristics of the study population.

<p>FTND, Fagerström Test for Nicotine Dependence; MNWS, Minnesota Nicotine Withdrawal Scale; COPD, chronic obstructive pulmonary disorder; ZSDS, Zung Self-Rating Depression Scale; SD, standard deviation; MDD, major depressive disorder.</p

Haplotype association tests on C3 phenotypic cluster in GLM and HapScore tests.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^a<i>p_model = 0.018</i>; GLM, general linear model.</p

Frequencies of different haplotypes in phenotypic clusters.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^achi-square test indicated a significantly higher frequency of GCC haplotype in C3 compared to non-C3 clusters.</p

Results of risk analysis of haplotype carrying in different phenotypic clusters.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. OR, odds ratio.</p

Two-step cluster analysis of three phenotypic variables resulted in three significantly different clusters.

<p>Mean scores are represented as percentages of possible maximum points for each measurements. MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale.</p

Kaplan-Meier curves for the OS of clinical variables of metastatic SCLC patients.

<p>(A) age <70 yrs vs. ≥70yrs (p = 0.001), (B) ECOG PS 0–1 vs. ECOG PS >1 (p<0.001), (C) male (vs. female; p = 0.021), and (D) radiation therapy (RT) vs. patients not treated with RT (p<0.001).</p

Kaplan-Meier curves for the OS of metastatic SCLC patients. Effect of FDA approved drugs.

<p>(A) Aspirin (vs. control; p = 0.225), (B) doxazosin and prazosin (vs. control; p<0.479), (C) selective serotonin reuptake inhibitors (SSRIs) (vs. control; p = 0.195), (D) statin treatment vs. control (p = 0.002) and, (E) clomipramine (a tricyclic antidepressant; TCA) vs. control had no effect on OS.</p

MOESM1 of Relationship of suicide rates with climate and economic variables in Europe during 2000–2012

Additional file 1. Web appendix