2 research outputs found
Overanticoagulation on coumarin anticoagulants
Most of the extensive research on oral anticoagulant therapy has focussed on
its pharmacological- and biochemical action, prothrombin time calibration, optimal
therapeutic intensity and hemorrhagic complications. However, whlle the
risks of overanticoagulation are clear, its treatment and determinants have
received little attention. Therefore, the aim of this thesis was to study aspects of
overanticoagulation on coumarin anticoagulants among outpatients of an anticoagulation
clinic. Overanticoagulation was defined as an INR:>6.0, since at this
INR-value the risk of hemorrhage sharply increases (28, 41). Chapter 2 relates
to the treatment of overanticoagulation and describes the course of the INR
in response to oral vitamin K1 in overanticoagulated patients. Chapter 3 concerns
the incidence of and risk factors for overanticoagulation and includes five
studies. Chapter 3.1 focusses on characteristics of antic
Existing data sources for clinical epidemiology: The pharmo database network
The PHARMO Database Network provides a unique opportunity to gain insight in the complete patient journey and healthcare in the Netherlands. The PHARMO Database Network is a population-based network of electronic healthcare databases and combines anonymous data from different primary and secondary healthcare settings in the Netherlands. Healthcare settings include general practitioners, out-patient and in-patient pharmacies, hospitals and clinical laboratories. Furthermore, databases are linked with external registries suc