research
Overanticoagulation on coumarin anticoagulants
- Publication date
- 1 January 2001
- Publisher
- Most of the extensive research on oral anticoagulant therapy has focussed on
its pharmacological- and biochemical action, prothrombin time calibration, optimal
therapeutic intensity and hemorrhagic complications. However, whlle the
risks of overanticoagulation are clear, its treatment and determinants have
received little attention. Therefore, the aim of this thesis was to study aspects of
overanticoagulation on coumarin anticoagulants among outpatients of an anticoagulation
clinic. Overanticoagulation was defined as an INR:>6.0, since at this
INR-value the risk of hemorrhage sharply increases (28, 41). Chapter 2 relates
to the treatment of overanticoagulation and describes the course of the INR
in response to oral vitamin K1 in overanticoagulated patients. Chapter 3 concerns
the incidence of and risk factors for overanticoagulation and includes five
studies. Chapter 3.1 focusses on characteristics of antico