134 research outputs found
Rapidly Fatal Acanthamoeba Encephalitis and Treatment of Cryoglobulinemia
We describe a 66-year-old woman with therapy-refractory cryoglobulinemia treated with rituximab, plasmapheresis, and steroids; a case of fatal meningoencephalitis caused by Acanthamoeba spp. then developed. Such infections are rare and show an unusually rapid course (possibly related to rituximab)
On the vertical distribution of carbon monoxide and methane in the stratosphere
info:eu-repo/semantics/publishe
The antimicrobial resistance crisis in hospitals calls for multidisciplinary mobilization
SCOPUS: ed.jinfo:eu-repo/semantics/publishe
„Extended”-spectrum-bètalactamase- en carbapenemaseproducerende Enterobacteriaceae:therapeutische aspecten
Abstract
Extended-spectrum beta-lactamaseand
carbapenemase-producing
Enterobacteriaceae: therapeutic
options
ESBL-producing (ESBL: extended-spectrum
beta-lactamase) Enterobacteriaceae can be
treated with a carbapenem or, to avoid the use
of carbapenems and according to the indication,
with fosfomycin, nitrofurantoin, tigecycline
and temocillin. It is less easy to treat carbapenemase-
producing Enterobacteriaceae (CPE)
as the number of available drugs is limited. Only
infections, but not colonisation with CPE should
be treated. A prudent and restricted use of antibiotics
for in- and outpatients is requested as
well. An infection with a CPE has to be treated
with a combination therapy: a carbapenem with
colistin and/or tigecycline. A complete antibiogram
with MIC-determinations (MIC: „minimal
inhibitory concentration”) is very helpful. If the
MIC of meropenem is ≤ 8/(16) mg/l, a highdose
carbapenem can still be used. The old
antibiotic colistin is also very important because
there are only a few alternatives.
The number of antibiotics developed during
the last 20 years is limited. Most large pharmaceutical
companies have reduced their antibiotic
research program due to insufficient financial
return. Many experts deplore this tragic
evolution.status: publishe
Een geval van koorts, artralgieën en huiduitslag bij terugkeer uit de tropen
In this manuscript, the case of a 58-year-old woman who presented with a fever, arthralgia, a headache and a pustular skin lesion after incurring an insect bite during a stay in Sub-Saharan Africa, is discussed. A rickettsial infection was suspected and a treatment with doxycycline initiated, resulting in a spectacular improvement of the symptoms. The pustule evolved into a black eschar and serologic testing confirmed the diagnosis of a Rickettsia conorii infection. The clinical characteristics of rickettsial infections are briefly reviewed.status: publishe
Comment on: Improving access to appropriate post-exposure doxycycline for Lyme disease prophylaxis: role for community pharmacies
status: publishe
Underlying factors in paediatric invasive pneumococcal disease in Belgium – Authors' reply
SCOPUS: le.jinfo:eu-repo/semantics/publishe
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