Photograph of live <i>E. clara</i> from the Cahaba River, Shelby County, Alabama.

<p>Photograph of live <i>E. clara</i> from the Cahaba River, Shelby County, Alabama.</p

Photograph of two eggs that were laid by captive <i>L. compacta.</i>

<p>Scale bar = 1 mm.</p

Photograph of live <i>L. compacta</i> from the Cahaba River, Shelby County, Alabama.

<p>Photograph of live <i>L. compacta</i> from the Cahaba River, Shelby County, Alabama.</p

Map of the Cahaba River and select tributaries.

<p>Historical collections sites were sampled in August 2011, but <i>L. compacta</i> was found only at the site of re-discovery.</p

Locality and museum catalogue numbers for <i>L. compacta</i> museum lots analyzed in this study.

*<p>Lot from which radulae were taken.</p

Growth series of <i>L. compacta</i>.

<p>A) <i>L. compacta</i> lectotype (MCZ 072063). B–E) Wild caught individuals. F) Juvenile grown in culture, approximately 4 months old. Scale bar = 5 mm.</p

Species collected in the May 2011 survey at the site of <i>L. compacta</i> re-discovery (33.178601°N, 87.017481°W).

<p><i>Lepyrium showalteri</i> was found, but not collected due its endangered status under the U.S. Endangered Species Act.</p

Shell Photographs

Shell photographs of museum lots relevant to the manuscript "On the identity of <i>Leptoxis taeniata</i> – a misapplied name for the federally threatened Painted Rocksnail (Cerithioidea: Pleuroceridae)"<p></p

Discovery of 4‑Amino‑<i>N</i>‑[(1<i>S</i>)‑1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7<i>H</i>‑pyrrolo[2,3‑<i>d</i>]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against the closely related AGC kinase ROCK. This compound demonstrated good preclinical drug metabolism and pharmacokinetics (DMPK) properties and, after oral dosing, showed pharmacodynamic knockdown of phosphorylation of Akt and downstream biomarkers in vivo, and inhibition of tumor growth in a breast cancer xenograft model