Participant flow through the trial.

<p>Participant flow through the trial.</p

Difference at baseline between students at high risk and low risk.

a<p>these variable were used in the logistic regression model to classify students and show significant differences per definition.</p

Estimated means for intervention and control group, by risk status and results of the linear mixed models analysis.

<p>Estimated means for intervention and control group, by risk status and results of the linear mixed models analysis.</p

Outline of trait-focused intervention content.

<p>Outline of trait-focused intervention content.</p

Analysis of contrasts between baseline and 12-week follow-up.

a<p>A Bonferroni correction was applied.</p

Demographic Characteristics of Participants at Baseline.

<p>Demographic Characteristics of Participants at Baseline.</p

Proposal for a four-step evaluation and approval process of prevention interventions for health-compromising behaviours.

<p>Proposal for a four-step evaluation and approval process of prevention interventions for health-compromising behaviours.</p

Criteria used in most widespread registries of evidence-based prevention interventions.

<p>This table is partly based on the work by Gandhi et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001740#pmed.1001740-Gandhi1" target="_blank">[22]</a>, with the addition of the EMCDDA Best Practice Portal <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001740#pmed.1001740-Bo1" target="_blank">[23]</a> and the Dutch Recognition System <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001740#pmed.1001740-Brug1" target="_blank">[24]</a>.</p>a<p>The application describes how the intervention is integrated into schools' educational mission.</p><p>Abbreviations: EMCDDA, European Monitoring Centre for Drugs and Drug Abuse; NIDA, National Institute on Drug Abuse; SAMHSA, Substance Abuse and Mental Health Services Administration; ED, US Department of Education; N/A, not available.</p><p>Criteria used in most widespread registries of evidence-based prevention interventions.</p

Population mean (Mean) and population variance (Standard deviation, SD) for Percent BOLD Signal Change (Ambiguous Facial expressions vs. Control Stimuli) and the Degree of Functional Connectivity (number of regions correlated with an r>0.3).

<p>Population mean (Mean) and population variance (Standard deviation, SD) for Percent BOLD Signal Change (Ambiguous Facial expressions vs. Control Stimuli) and the Degree of Functional Connectivity (number of regions correlated with an r>0.3).</p

Relationships between SNP-based estimates of heritability, population variance in functional connectivity and the BOLD response.

<p>A) Relationship between GREML-based heritability estimates (Genetic Variance/Phenotypic Variance) and the population variance (standard deviation, SD) of functional connectivity (node degree) across 25 ROIs for the Ambiguous face viewing contrast. B) Relationship between the population variance (SD) and the population mean of degree across the 25 ROIs. C) Relationship between population mean of the brain response (percent BOLD signal change, %BSC) and the population variance (SD) of degree across the 25 ROIs. For all three plots, colour is scaled according to the GREML results for %BSC (cyan for low values and red for high values). VG, Genetic Variance; Vp, Phenotypic Variance.</p