General characteristics of children aged 6 months to 10 years (N = 1111).

a<p>Totals differ from the total number of study children because of missing values.</p

Iron status indicators and prevalence of anemia and other nutritional and non-nutritional conditions in urban Amazonian children^a.

<p>IQR, interquartile ranges.</p>a<p>Totals in brackets differ from the total number of study children by age group because of missing values.</p>b<p>Cut-offs for anemia: <110.0 and <115.0 g/L for 6–59 months and ≥60 months, respectively;</p>c<p>Cut-offs for microcytosis by age: <67, <73, <74, and <76 fl for <24 months, 24–59 months, 5–7.9 years, and 8–11.9 years, respectively;</p>d<p>PF: <12 and <15 µg/L for <59 and ≥60 months, respectively;</p>e<p>sTfR: >8.3 mg/L;</p>f<p>Cut-off for high CRP: >5 mg/L;</p>g<p>CRP index defined as (0.34+0.0043×PF – [2.7×sTfR]/PF+0.00696×CRP+0.05×sTfR);</p>h<p>Serum retinol <0.70µmol/L;</p>i<p>Serum vitamin B₁₂<150 pmol/L;</p>j<p>Serum folate <10 nmol/L;</p>k<p>According to cut-offs for PF or sTfR.</p>l<p>Geohelminths in this population included <i>Ascaris lumbricoides</i> (overall prevalence, 2.4%), <i>Strongyloides stercoralis</i> (0.5%), and <i>Trichuris trichiura</i> (0.8%) - the same subject may be co-infected with more than one species.</p

Multiple linear regression analysis of factors associated with hemoglobin in urban Amazonian children.

a<p>Total differs from total number of study children because of missing values.</p

Attributable fractions (AF) of anemia according to age group in urban Amazonian children.

a<p>Prevalence (%) of cases exposed in each risk factors.</p>b<p>Adjusted prevalence ratio (aPR) estimated from multiple Poisson regression models with additional adjustment for age (in overall analysis), sex, wealth index (quartile), maternal schooling (≤4, 5–8, and ≥9 years), and maternal age (10–21, 22–35, and >35 years).</p>c<p>Attributable fraction defined as p(aPR –1)/aPR.</p

Frequency (%) of iron deficiency (<i>A</i>), iron deficiency anemia (<i>B)</i> and vitamin A deficiency (<i>C</i>) stratified by inflammation status using combined plasma values of CRP and AGP according to ENFAC study groups.

<p>Reference, CRP ≤ 5mg/L and AGP ≤ 1g/L, <i>n</i> = 302 (<i>A</i> and <i>B</i>) or 296 (<i>C</i>) in CG, and <i>n</i> = 275 (<i>A</i> and <i>B</i>) or 274 (<i>C</i>) in IG; Chronic, CRP ≤ 5mg/L and AGP> 1g/L, <i>n</i> = 83 (<i>A</i> and <i>B</i>) or 84 (<i>C</i>) in CG, and <i>n</i> = 59 (<i>A</i>, <i>B</i> or <i>C</i>) in IG; Acute, CRP >5 and AGP> 1g/L mg/L, <i>n</i> = 68 (<i>A</i> and <i>B</i>) or 65 (<i>C)</i> in CG, and <i>n</i> = 30 (<i>A</i> and <i>B</i>) or 27 (<i>C</i>) in IG. Totals differ from the total number of study children due to missing values for biochemical indicators. The symbol * indicates significant differences for the IG compared with CG (Pearson χ² test). AGP, α-1-acid glycoprotein; CG, control group; CRP, C-reactive protein; ENFAC, <i>Estudo Nacional de Fortificação caseira da Alimentação Complementar;</i> IG, intervention group.</p

Flow of participants in the ENFAC study.

<p>CG, control group; ENFAC, <i>Estudo Nacional de Fortificação caseira da Alimentação Complementar</i>; IG, intervention group.</p

Prevalence of anemia and biochemical indicators by study groups at the end of the ENFAC Study^a.

<p>Prevalence of anemia and biochemical indicators by study groups at the end of the ENFAC Study<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151097#t003fn001" target="_blank">^a</a>.</p

Nutrient composition of the MNP used in the ENFAC Study^a.

<p>Nutrient composition of the MNP used in the ENFAC Study<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151097#t001fn001" target="_blank">^a</a>.</p

Characteristics of the participants by ENFAC study groups^a.

<p>Characteristics of the participants by ENFAC study groups<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151097#t002fn001" target="_blank">^a</a>.</p