15 research outputs found
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School Choice Overseas: Are Parents Citizens or Consumers?
Currently, some Korean parents are educating their children in primary and secondary schools in foreign countries even though Korean schools demonstrate high performance as confirmed by the Programme for International Student Assessment (PISA) Report. Using Hirschman's (1970) framework of "exit" and "voice," this study investigated characteristics of exiting parents and their reasons for educating their child(ren) in foreign schools. This study also examined the organizational, political and educational context of Korea, including the High School Equalization Policy (HSEP), private tutoring, change in the study abroad law, and the role these play in leading some families to leave their domestic local schools. A survey questionnaire was administered to two groups of parents - parents whose children attend school domestically (staying parents) and parents whose children attend school abroad (exiting parents). Purposive sampling was implemented for data collection. Analysis employed logistic regression to assess which factors significantly contributed to the decision to exit or to stay. This study's finding confirmed Hirschman's argument that exit may increase when opportunities for voice are limited. Before choosing schools in foreign countries, exiting Korean parents expressed their voice more actively at the school level than did staying parents. While exiting parents were prone to speak directly to the teachers, principals, and school staff at the school level, staying parents were more likely to vocalize their voice through city and national level elections by actively demonstrating political action by casting ballots. Staying parents were more likely to choose their children's school by residential choice. In evaluating Korean schools, exiting parents gave lower marks to the local schools where their children attended while scoring Korean schools in general higher
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Multiscale Thermal Design for Buildings
This dissertation investigates the principles, processes, and strategies to develop multiscale material systems for buildings that interact with heat in novel ways. The overall theoretical framework consists of (1) utilizing the multiscale configuration of biological material systems as the principle for the design of building element; (2) using the shape and size of heat flow as the key parameter for the design and optimization of the building elements; and (3) applying the principles of materials and material processes for selecting and configuring the material systems. This framework is examined in Part I through literature review and case studies; and implemented in Part II through a series of experiments for the designing, prototyping and testing a thermally augmented building envelope system. The results of the analytical model and the physical testing show strong correlations which validate the usage of the analytical model in the thermal optimization of building elements at a wide range of geometric and temperature variations. To evaluate the performance of the system standards including the recommended U-value for building envelopes and the targeted ventilation and heat recovery rate per occupant is used. The overall dissertation can provide architects with the essential knowledge and strategies for developing thermally augmented building elements. Similarly, the research can also inform the scientists and engineers on the thermal design constraints and opportunities relating to building applications. Although this research is focused on heat as the key environmental factor, the theoretical framework can be extended to other factors such as light and sound
Happiness Education: International Use of Floating Signifiers in Education Policy // ํ๋ณต๊ต์ก: ๊ต์ก์ ์ฑ ์์์ ๋ถ์ ๊ธฐํ์ ์๋์ ์ธ์ด ์ค์ฉ
Over the past decade, the concept of โhappinessโ has been promoted by global agencies and national education authorities as a solution to the social problems of high teenager suicide rates, school bullying, and increasing socioeconomic polarization. This article considers โHEP: Happiness Education Policyโ in Korea, which was initiated by conservative Park Geun-hye administration (2013-2017) and partly succeeded by the subsequent progressive Moon Jae-in administration (2017-2022). The analysis reveals that the definitional ambiguity of happiness education has opened a space for multiple ascriptions of meanings, particularly those that are in line with the Park administrationโs political and economic visions of โcreative economyโ. It also demonstrates that policies introduced as part of the HEP, such as the Free Semester initiative, have continued to be promoted and even expanded by Moon administration (2017-2022) despite their replacement of the signifier โhappinessโ by โinnovationโ and โfutureโ. Therefore, this study suggests happiness education and, more lately, future education as good examples of โfloating signifiersโ; that is, by lacking a clear referent, they minimize political objections and legitimate the introduction and continuation of contested reforms. //
๋ณธ ์ฐ๊ตฌ๋ ์ ์ฑ
์ ์ด ๋ฐ ์ฐจ์ฉ ์ด๋ก ์ ๊ทผ๊ฑฐํ์ฌ ๋ฐ๊ทผํ ์ ๋ถ์ โ๊ฟ๊ณผ ๋ผ๋ฅผ ํค์ฐ๋ ํ๋ณต๊ต์ก ์ ์ค์ฌ์ผ๋ก ์ ์ฑ
๋ช
์นญ๊ณผ ๊ด๋ จ๋ ์ธ์ด์ ์๋์ ์ค์ฉ ํ์์ ๋ํด ๋ถ์ํ์๋ค.
ํ๋ณต๊ต์ก์ ๊ฒฝ์ฐ OECD๊ฐ ์ธ๋์ ์ ํ(humanitarian turn)์ ์๋ํ๋ฉฐ 2012 ๊ตญ์ ํ์
์ฑ์ทจ๋ ํ๊ฐ (PISA)์ ์ฒ์ ๋์
ํ ํ๋ณต ๋ฐ ์ฐ๋น ๋ฌธํญ๋ค๋ก ๊ตฌ์ฒดํ๋์ด ์ ์ด ๋์๋ค. ๋ํ๋ฏผ๊ตญ ํ์๋ค์ ๋ฎ์ ์ถ์ ๋ง์กฑ๋์ ๋ํ ์ฌํ์ ๋
ผ๋๊ณผ ๋ถ์ ๋ฝ ๊ต์ก์ ๋ํ ํ์์ด โ๋์ โ์ด๋ผ๋ ์ด๋ฒคํธ์ ๊ฒฐํฉํด โํ๋ณต ๊ต์ก ์ด๋ผ๋ ๋์์ผ๋ก ์ฐจ์ฉ๋์๋ค.
์ต๊ทผ OECD์์๋ โํ๋ณต ๋ฐ โ์ฐ๋น ์ด๋ผ๋ ์ฉ์ด๋ค์ด ๊ต์ก ์ฑ๊ณผ์ ์ฒ๋๋ฅผ ๋์ด์ ๋ฏธ๋ ์ฐ์ ์ธ๋ ฅ์ด ํ์์ ์ผ๋ก ์ง๋
์ผํ ์์ง ๋ฐ ์ญ๋์ผ๋ก ๊ฐ์กฐ๋๋ ๋ฑ ์ธ๋์ ์ ํ์ ์์ฑ๊ฐ ์ง์์ง๊ณ ์๋ค. ํ ๋ฌธ์ฌ์ธ ์ ๋ถ์์๋ ์์ ํ๋
์ ๋ฑ ์ด์ ์ ๋ถ์ ํ๋ณต๊ต์ก ๊ธฐ์กฐ ์๋ ๋ฑ์ฅํ๋ ์ ์ฑ
๊ณผ์ ๋ค์ด ๊ณ์ํด์ ์ด์ด์ง๊ณ ์์ผ๋, ๊ธฐ์กด โํ๋ณต ์ด๋ผ๋ ์์์ด๋ ๋ฏธ๋, ํ์ , ๊ณต์ , ํ๋ฑ ๋ฑ ์๋ก์ด ์ฉ์ด๋ก ๋ณํํ์๋ค. ๊ทธ๋ฌ๋ ํ๋ณต๊ต์ก๊ณผ ๋ง์ฐฌ๊ฐ์ง๋ก, โํ์ , โ๋ฏธ๋ ๋ฑ์ ์ฉ์ด๊ฐ ์๋ฏธํ๋ ๋ฐ์ ๋ํด์๋ ์๋ฏธ๊ฐ ๋ถ๋ถ๋ช
ํ์ฌ ํด์ ๋ฐ ์ฌ์ฉ์ด ์์์ ์ผ๋ก ์ด๋ฃจ์ด์ง๊ณ ์๋ค. ๋ณธ ์ฐ๊ตฌ๋ ์ด๋ฐ ์์์ด๋ค์ด ๊ต์ก์ ์ฑ
๋์
์ ์ ๋นํํ๋ ํ๋์ โ๋ถ์ ๊ธฐํ (floating signifier)๋ก ์์ฉํ๊ณ ์์ผ๋ฉฐ, ์ด์ ๊ฐ์ ์ธ์ด์ ์๋์ ์ค์ฉ ํ์์ ์๋ฌต์ ์ธ ์๋น์ ํฉ์ (bipartisanship)๋ก ๊ฐํ๋์์์ ๋ฐํ๋ค
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Dynamic daylight control system implementing thin cast arrays of polydimethylsiloxane-based millimeter-scale transparent louvers
The deep building layouts typical in the U.S. have led to a nearly complete reliance on artificial lighting in standard office buildings. The development of daylight control systems that maximize the penetration and optimize the distribution of natural daylight in buildings has the potential for saving a significant portion of the energy consumed by artificial lighting, but existing systems are either static, costly, or obstruct views towards the outside. We report the Dynamic Daylight Control System (DDCS) that integrates a thin cast transparent polydimethylsiloxane (PDMS)-based deformable array of louvers and waveguides within a millimeter-scale fluidic channel system. This system can be dynamically tuned to the different climates and sun positions to control daylight quality and distribution in the interior space. The series of qualitative and quantitative tests confirmed that DDCS exceeds conventional double glazing system in terms of reducing glare near the window and distributing light to the rear of the space. The system can also be converted to a visually transparent or a translucent glazing by filling the channels with an appropriate fluid. DDCS can be integrated or retrofitted to conventional glazing systems and allow for diffusivity and transmittance control.Chemistry and Chemical Biolog
Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis
Abstract
Objectives
Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for rheumatoid arthritis (RA).
Methods
HDAC6 was overexpressed in mouse peritoneal macrophages and RAW 264.7 cells, and the effects of a HDAC6 inhibitor CKD-506 on cytokine production and activity of NF-ฮบB and AP-1 signaling were examined. Peripheral blood mononuclear cells (PBMCs) from RA patients and fibroblast-like synoviocytes (FLS) were activated in the presence of CKD-506. Next, regulatory T cells (Tregs) were induced from RA patients and co-cultured with healthy effector T cells (Teffs) and cell proliferation was analyzed by flow cytometry. Finally, the effects of the inhibitor on the severity of arthritis were assessed in a murine model of adjuvant-induced arthritis (AIA).
Results
Overexpression of HDAC6 induced macrophages to produce TNF-ฮฑ and IL-6. The inhibitory effect of CKD-506 was mediated via blockade of NF-ฮบB and AP-1 activation. HDAC6 inhibition reduced TNF-ฮฑ and IL-6 production by activated RA PBMCs. CKD-506 inhibited production of MMP-1, MMP-3, IL-6, and IL-8 by activated FLS. In addition, CKD-506 inhibited proliferation of Teffs directly and indirectly by improving iTreg function. In AIA rats, oral CKD-506 improved clinical arthritis in a dose-dependent manner. A combination of sub-therapeutic CKD-506 and methotrexate exerted a synergistic effect.
Conclusion
The novel HDAC6 inhibitor CKD-506 suppresses inflammatoryresponses by monocytes/macrophages, improves Treg function, and ameliorates arthritis severity in a murine model of RA. Thus, CKD-506 might be a novel and effective treatment option for RA
Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis
Background
To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA).
Methods
FLS from RA patients were activated with interleukin (IL)-1ฮฒ in the presence of increasing concentrations of M808, a novel specific HDAC6 inhibitor. Production of ILs, chemokines, and metalloproteinases (MMPs) was measured in ELISAs. Acetylation of tubulin and expression of ICAM-1 and VCAM-1 were assessed by Western blotting. Wound healing and adhesion assays were performed. Cytoskeletal organization was visualized by immunofluorescence. Finally, the impact of HDAC6 inhibition on the severity of arthritis and joint histology was examined in a murine model of adjuvant-induced arthritis (AIA).
Results
HDAC6 was selectively inhibited by M808. The HDAC6 inhibitor suppressed the production of MMP-1, MMP-3, IL-6, CCL2, CXCL8, and CXCL10 by RA-FLS in response to IL-1ฮฒ. Increased acetylation of tubulin was associated with decreased migration of RA-FLS. Inhibiting HDAC6 induced cytoskeletal reorganization in RA-FLS by suppressing the formation of invadopodia following activation with IL-1ฮฒ. In addition, M808 tended to decrease the expression of ICAM-1 and VCAM-1. In the AIA arthritis model, M808 improved the clinical arthritis score in a dose-dependent manner. Also, HDAC6 inhibition was associated with less severe synovial inflammation and joint destruction.
Conclusion
Inhibiting HDAC6 dampens the inflammatory and destructive activity of RA-FLS and reduces the severity of arthritis. Thus, targeting HDAC6 has therapeutic potential.This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number:HI14C1277); the Ministry of Science, ICT and Future Planning (NRF2020M3E5E2037430, 2019M3A9A8065574); and the Chong Kun Dang
Pharmaceutical Corp. TP was supported by the DFG (FOR2722)
Faculty Publications for Academic Year 2018-19
Faculty publications of School of Architecture for the academic year 2018- 201
TOPO-Joint: Reliability-based topology optimization framework for 3D-printed building joints
A Reliability-based Topology Optimization framework with the integration of a parametric design process and additive manufacturing technique is proposed in this paper. The proposed method is applied to design architectural and structural joints subjected to uncertain load and material property. Optimal joint designs from various architectural and structural design consideration are discussed through numerical applications. A study is conducted on the comparison between deterministic and reliability-based topology optimization approaches