15 research outputs found

    Happiness Education: International Use of Floating Signifiers in Education Policy // ํ–‰๋ณต๊ต์œก: ๊ต์œก์ •์ฑ…์—์„œ์˜ ๋ถ€์œ ๊ธฐํ‘œ์™€ ์˜๋„์  ์–ธ์–ด ์˜ค์šฉ

    Get PDF
    Over the past decade, the concept of โ€˜happinessโ€™ has been promoted by global agencies and national education authorities as a solution to the social problems of high teenager suicide rates, school bullying, and increasing socioeconomic polarization. This article considers โ€˜HEP: Happiness Education Policyโ€™ in Korea, which was initiated by conservative Park Geun-hye administration (2013-2017) and partly succeeded by the subsequent progressive Moon Jae-in administration (2017-2022). The analysis reveals that the definitional ambiguity of happiness education has opened a space for multiple ascriptions of meanings, particularly those that are in line with the Park administrationโ€™s political and economic visions of โ€˜creative economyโ€™. It also demonstrates that policies introduced as part of the HEP, such as the Free Semester initiative, have continued to be promoted and even expanded by Moon administration (2017-2022) despite their replacement of the signifier โ€˜happinessโ€™ by โ€˜innovationโ€™ and โ€˜futureโ€™. Therefore, this study suggests happiness education and, more lately, future education as good examples of โ€˜floating signifiersโ€™; that is, by lacking a clear referent, they minimize political objections and legitimate the introduction and continuation of contested reforms. // ๋ณธ ์—ฐ๊ตฌ๋Š” ์ •์ฑ… ์ „์ด ๋ฐ ์ฐจ์šฉ ์ด๋ก ์— ๊ทผ๊ฑฐํ•˜์—ฌ ๋ฐ•๊ทผํ˜œ ์ •๋ถ€์˜ โ€˜๊ฟˆ๊ณผ ๋ผ๋ฅผ ํ‚ค์šฐ๋Š” ํ–‰๋ณต๊ต์œก ์„ ์ค‘์‹ฌ์œผ๋กœ ์ •์ฑ… ๋ช…์นญ๊ณผ ๊ด€๋ จ๋œ ์–ธ์–ด์˜ ์˜๋„์  ์˜ค์šฉ ํ˜„์ƒ์— ๋Œ€ํ•ด ๋ถ„์„ํ•˜์˜€๋‹ค. ํ–‰๋ณต๊ต์œก์˜ ๊ฒฝ์šฐ OECD๊ฐ€ ์ธ๋„์  ์ „ํ™˜(humanitarian turn)์„ ์‹œ๋„ํ•˜๋ฉฐ 2012 ๊ตญ์ œ ํ•™์—…์„ฑ์ทจ๋„ ํ‰๊ฐ€ (PISA)์— ์ฒ˜์Œ ๋„์ž…ํ•œ ํ–‰๋ณต ๋ฐ ์›ฐ๋น™ ๋ฌธํ•ญ๋“ค๋กœ ๊ตฌ์ฒดํ™”๋˜์–ด ์ „์ด ๋˜์—ˆ๋‹ค. ๋Œ€ํ•œ๋ฏผ๊ตญ ํ•™์ƒ๋“ค์˜ ๋‚ฎ์€ ์‚ถ์˜ ๋งŒ์กฑ๋„์— ๋Œ€ํ•œ ์‚ฌํšŒ์  ๋…ผ๋ž€๊ณผ ๋ถ์œ ๋Ÿฝ ๊ต์œก์— ๋Œ€ํ•œ ํ™˜์ƒ์ด โ€˜๋Œ€์„ โ€™์ด๋ผ๋Š” ์ด๋ฒคํŠธ์™€ ๊ฒฐํ•ฉํ•ด โ€˜ํ–‰๋ณต ๊ต์œก ์ด๋ผ๋Š” ๋Œ€์•ˆ์œผ๋กœ ์ฐจ์šฉ๋˜์—ˆ๋‹ค. ์ตœ๊ทผ OECD์—์„œ๋Š” โ€˜ํ–‰๋ณต ๋ฐ โ€˜์›ฐ๋น™ ์ด๋ผ๋Š” ์šฉ์–ด๋“ค์ด ๊ต์œก ์„ฑ๊ณผ์˜ ์ฒ™๋„๋ฅผ ๋„˜์–ด์„œ ๋ฏธ๋ž˜ ์šฐ์ˆ˜ ์ธ๋ ฅ์ด ํ•„์ˆ˜์ ์œผ๋กœ ์ง€๋…€์•ผํ•  ์ž์งˆ ๋ฐ ์—ญ๋Ÿ‰์œผ๋กœ ๊ฐ•์กฐ๋˜๋Š” ๋“ฑ ์ธ๋„์  ์ „ํ™˜์˜ ์ƒ‰์ฑ„๊ฐ€ ์ง€์›Œ์ง€๊ณ  ์žˆ๋‹ค. ํ˜„ ๋ฌธ์žฌ์ธ ์ •๋ถ€์—์„œ๋„ ์ž์œ ํ•™๋…„์ œ ๋“ฑ ์ด์ „ ์ •๋ถ€์˜ ํ–‰๋ณต๊ต์œก ๊ธฐ์กฐ ์•„๋ž˜ ๋“ฑ์žฅํ–ˆ๋˜ ์ •์ฑ…๊ณผ์ œ๋“ค์ด ๊ณ„์†ํ•ด์„œ ์ด์–ด์ง€๊ณ  ์žˆ์œผ๋‚˜, ๊ธฐ์กด โ€˜ํ–‰๋ณต ์ด๋ผ๋Š” ์ˆ˜์‹์–ด๋Š” ๋ฏธ๋ž˜, ํ˜์‹ , ๊ณต์ •, ํ‰๋“ฑ ๋“ฑ ์ƒˆ๋กœ์šด ์šฉ์–ด๋กœ ๋ณ€ํ™”ํ•˜์˜€๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ํ–‰๋ณต๊ต์œก๊ณผ ๋งˆ์ฐฌ๊ฐ€์ง€๋กœ, โ€˜ํ˜์‹  , โ€˜๋ฏธ๋ž˜ ๋“ฑ์˜ ์šฉ์–ด๊ฐ€ ์˜๋ฏธํ•˜๋Š” ๋ฐ”์— ๋Œ€ํ•ด์„œ๋Š” ์˜๋ฏธ๊ฐ€ ๋ถˆ๋ถ„๋ช…ํ•˜์—ฌ ํ•ด์„ ๋ฐ ์‚ฌ์šฉ์ด ์ž์˜์ ์œผ๋กœ ์ด๋ฃจ์–ด์ง€๊ณ  ์žˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์ด๋Ÿฐ ์ˆ˜์‹์–ด๋“ค์ด ๊ต์œก์ •์ฑ… ๋„์ž…์„ ์ •๋‹นํ™”ํ•˜๋Š” ํ•˜๋‚˜์˜ โ€˜๋ถ€์œ  ๊ธฐํ‘œ (floating signifier)๋กœ ์ž‘์šฉํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ์ด์™€ ๊ฐ™์€ ์–ธ์–ด์˜ ์˜๋„์  ์˜ค์šฉ ํ˜„์ƒ์€ ์•”๋ฌต์ ์ธ ์–‘๋‹น์˜ ํ•ฉ์˜ (bipartisanship)๋กœ ๊ฐ•ํ™”๋˜์—ˆ์Œ์„ ๋ฐํ˜”๋‹ค

    Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis

    Get PDF
    Abstract Objectives Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for rheumatoid arthritis (RA). Methods HDAC6 was overexpressed in mouse peritoneal macrophages and RAW 264.7 cells, and the effects of a HDAC6 inhibitor CKD-506 on cytokine production and activity of NF-ฮบB and AP-1 signaling were examined. Peripheral blood mononuclear cells (PBMCs) from RA patients and fibroblast-like synoviocytes (FLS) were activated in the presence of CKD-506. Next, regulatory T cells (Tregs) were induced from RA patients and co-cultured with healthy effector T cells (Teffs) and cell proliferation was analyzed by flow cytometry. Finally, the effects of the inhibitor on the severity of arthritis were assessed in a murine model of adjuvant-induced arthritis (AIA). Results Overexpression of HDAC6 induced macrophages to produce TNF-ฮฑ and IL-6. The inhibitory effect of CKD-506 was mediated via blockade of NF-ฮบB and AP-1 activation. HDAC6 inhibition reduced TNF-ฮฑ and IL-6 production by activated RA PBMCs. CKD-506 inhibited production of MMP-1, MMP-3, IL-6, and IL-8 by activated FLS. In addition, CKD-506 inhibited proliferation of Teffs directly and indirectly by improving iTreg function. In AIA rats, oral CKD-506 improved clinical arthritis in a dose-dependent manner. A combination of sub-therapeutic CKD-506 and methotrexate exerted a synergistic effect. Conclusion The novel HDAC6 inhibitor CKD-506 suppresses inflammatoryresponses by monocytes/macrophages, improves Treg function, and ameliorates arthritis severity in a murine model of RA. Thus, CKD-506 might be a novel and effective treatment option for RA

    Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis

    Get PDF
    Background To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). Methods FLS from RA patients were activated with interleukin (IL)-1ฮฒ in the presence of increasing concentrations of M808, a novel specific HDAC6 inhibitor. Production of ILs, chemokines, and metalloproteinases (MMPs) was measured in ELISAs. Acetylation of tubulin and expression of ICAM-1 and VCAM-1 were assessed by Western blotting. Wound healing and adhesion assays were performed. Cytoskeletal organization was visualized by immunofluorescence. Finally, the impact of HDAC6 inhibition on the severity of arthritis and joint histology was examined in a murine model of adjuvant-induced arthritis (AIA). Results HDAC6 was selectively inhibited by M808. The HDAC6 inhibitor suppressed the production of MMP-1, MMP-3, IL-6, CCL2, CXCL8, and CXCL10 by RA-FLS in response to IL-1ฮฒ. Increased acetylation of tubulin was associated with decreased migration of RA-FLS. Inhibiting HDAC6 induced cytoskeletal reorganization in RA-FLS by suppressing the formation of invadopodia following activation with IL-1ฮฒ. In addition, M808 tended to decrease the expression of ICAM-1 and VCAM-1. In the AIA arthritis model, M808 improved the clinical arthritis score in a dose-dependent manner. Also, HDAC6 inhibition was associated with less severe synovial inflammation and joint destruction. Conclusion Inhibiting HDAC6 dampens the inflammatory and destructive activity of RA-FLS and reduces the severity of arthritis. Thus, targeting HDAC6 has therapeutic potential.This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number:HI14C1277); the Ministry of Science, ICT and Future Planning (NRF2020M3E5E2037430, 2019M3A9A8065574); and the Chong Kun Dang Pharmaceutical Corp. TP was supported by the DFG (FOR2722)

    Editorial

    No full text

    TOPO-Joint: Reliability-based topology optimization framework for 3D-printed building joints

    No full text
    A Reliability-based Topology Optimization framework with the integration of a parametric design process and additive manufacturing technique is proposed in this paper. The proposed method is applied to design architectural and structural joints subjected to uncertain load and material property. Optimal joint designs from various architectural and structural design consideration are discussed through numerical applications. A study is conducted on the comparison between deterministic and reliability-based topology optimization approaches
    corecore