Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens

<p>Abstract</p> <p>Background</p> <p>Boswellic acids mixture of triterpenic acids obtained from the oleo gum resin of <it>Boswellia serrata </it>and known for its effectiveness in the treatment of chronic inflammatory disease including peritumor edema. Boswellic acids have been extensively studied for a number of activities including anti inflammatory, antitumor, immunomodulatory, and inflammatory bowel diseases. The present study describes the antimicrobial activities of boswellic acid molecules against oral cavity pathogens. Acetyl-11-keto-β-boswellic acid (AKBA), which exhibited the most potent antibacterial activity, was further evaluated in time kill studies, mutation prevention frequency, postantibiotic effect (PAE) and biofilm susceptibility assay against oral cavity pathogens.</p> <p>Findings</p> <p>AKBA exhibited an inhibitory effect on all the oral cavity pathogens tested (MIC of 2-4 μg/ml). It exhibited concentration dependent killing of S<it>treptococcus mutans </it>ATCC 25175 up to 8 × MIC and also prevented the emergence of mutants of <it>S.mutans </it>ATCC 25175 at 8× MIC. AKBA demonstrated postantibiotic effect (PAE) of 5.7 ± 0.1 h at 2 × MIC. Furthermore, AKBA inhibited the formation of biofilms generated by <it>S.mutans </it>and <it>Actinomyces viscosus </it>and also reduced the preformed biofilms by these bacteria.</p> <p>Conclusions</p> <p>AKBA can be useful compound for the development of antibacterial agent against oral pathogens and it has great potential for use in mouthwash for preventing and treating oral infections.</p

Titanium(IV) & Organotin(IV) Chelates of S-Benzyl-β-N-(2-Hydroxy-phenyl)methylen Dithiocarbazate

130-13

Chelated Titanium(IV) & Organotin(IV) Derivatives of Mixed Azines

73-7

Isopropylation of naphthalene over large pore zeolites

469-472Isopropylation of naphthalene with isopropanol (IPA) proceeds at 200°C over the large pore zeolites HY, Hβ, H-Mordenite and REY in the presence of N2. Over Hβ, conversion is more in N2 than when cyclohexane is used as solvent or in absence of N2. Conversions and selectivities to diisopropyl naphthalenes fall in the sequence Hβ > REY > HM > HY, but 2,6: 2,7 ratio is greatest with HM.With Hβ, conversion is maximum at 200°C, and increasing the IPA : naphthalene ratio leads to deactivation of the catalyst

New Organoxytitanium(IV) & Organotin(IV) Derivatives of N-Salicylidene-N’-Salicylhydrazide

239-24

Zeolite-encapsulated Cu(II)-salen complex as a catalyst for oxidation of cyclohexanol

1-3Cu (salen) complex encapsulated in zeolite Y is characterized by elemental analysis, IR, UV-vis and ESR spectroscopy and is shown to be a catalyst for the selective oxidation of cyclohexanol to cyclohexanone in the presence of H2O2 under much milder conditions (80°C) than those in current practice

Chelated Titanium(IV) & Organotin(IV) Derivatives of Schiff Bases Derived from Isonicotinic Acid Hydrazide & Salicylaldehyde, Acetylacetone, Trifluoroacetylacetone or Thenoylacetone

1137-113

Gas-phase oxidant-free oxidation of cyclohexanol overV₂O₅-MoO₃-M₂O (M = Na, K, Cs) catalysts

43-49Oxidant-free oxidation (dehydrogenation) of cyclohexanol is carried out in a down-flow integral laboratory scale reactor using different alkali doped catalysts. The effect of reaction temperature, contact time (W/F) and doping of alkali metals is studied to check its effect on nature of prominent products of the reaction (cyclohexanone and cyclohexene). At lower temperature the cyclohexanone prevails whereas at higher temperature cyclohexene is observed in prominence. Acid-modified catalysts (with boron and phosphorous) facilitated cyclohexene selectivity whereas alkali modified catalysts facilitated cyclohexanone selectivity. Calcination of sodium modified catalyst at different temperatures under static condition affect characteristic phase intensity and cyclohexanone selectivity. XRD investigation showed formation of different inorganic phases as the characteristic of dopant. Cesium modified catalyst showed better dehydrogenation activity

Chlorotitanium(IV) Derivatives of Salicylaldehyde Hydrazone & o-Hydroxyacetophenone Hydrazone, & Their Addition Compounds with Nitrogen Bases

173-17