264 research outputs found

    Zwey Buecher Theophrasti Paracelsi des erfar, nesten ... von der Pestilentz und ihren ZĆŻfaellen / durch ... Adamen von Bodenstein, in Druck verfertiget ...

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    https://digitalcommons.wustl.edu/paracelsus/1011/thumbnail.jp

    Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities

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    The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to perceived obstacles of cost and analysis. One barrier to examining transcriptional dose responses is that existing methods for microarray data analysis can identify patterns, but provide no quantitative pharmacological information. We developed analytical methods that identify transcripts responsive to dose, calculate classical pharmacological parameters such as the EC50, and enable an in-depth analysis of coordinated dose-dependent treatment effects. The approach was applied to a transcriptional profiling study that evaluated four kinase inhibitors (imatinib, nilotinib, dasatinib and PD0325901) across a six-logarithm dose range, using 12 arrays per compound. The transcript responses proved a powerful means to characterize and compare the compounds: the distribution of EC50 values for the transcriptome was linked to specific targets, dose-dependent effects on cellular processes were identified using automated pathway analysis, and a connection was seen between EC50s in standard cellular assays and transcriptional EC50s. Our approach greatly enriches the information that can be obtained from standard transcriptional profiling technology. Moreover, these methods are automated, robust to non-optimized assays, and could be applied to other sources of quantitative data

    Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

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    This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

    Aureoli Philippi Theophrasti Bombasts von Hohenheim Paracelsi ... Opera. [Theil 1]

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    Elektronische Reproduktion von: Aureoli Philippi Theophrasti Bombasts von Hohenheim Paracelsi ... Opera : BĂŒcher und Schrifften, so viel deren zur Handt gebracht, und vor wenig Jahren mit und auß ihren glaubwĂŒrdigen eigener hangeschriebenen Originalien collacioniert, vergliechen, verbessert / und durch Ioannem Huserum Brisgoium in zehen unterschiedliche Theil in Truck gegeben. Theil [1]. - Jetzt von newem mit vleiß ubersehen ... in zwey unterschiedliche Tomos und Theil gebracht ... - Straßburg : Zetzner, 1603. - [6] Bl., 1127 S., [1] S., [26] Bl. ; 2°. - Standort: UniversitĂ€t Marburg, UniversitĂ€tsbibliothek. - Signatur: 085 4 2023/00196. - Fingerprint: erls xths asbs matu 3 1603R 1. - Anmerkung: Vorlageform des Erscheinungsvermerks: Straßburg, In verlegung Lazari Zetzners BuchhĂ€ndlers. Anno. M. DCIII. - Bibliographischer Nachweis: Verzeichnis der im deutschen Sprachbereich erschienenen Drucke des 17. Jahrhunderts, 12:168467C. - Digitalisiert 202
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