Hubungan Antara Kepatuhan Minum Obat (MMAS-8) Dan Kualitas Hidup (WHOQOL-BREF) Penderita Tuberkulosis Di Puskesmas Di Kota Bandung

Backgroumd: Tuberculosis (TB) is an infectious disease which is until now has not been able to be threated, i.e., because of patient non-adherence in taking anti-tuberculosis drug (ATD) Objective: The objective of this research is  to study the relationship between patients adherence in taking ATD determined by MMAS-8 questionnaire with QoL of patient determined by WHOQOL questionnaire. Method: Tuberculosis patients who undergo treatment for at least 4 weeks are the subjects in this study. This study was conducted by a cross-sectional method using the MMAS-8 and WHOQOL-BREF questionnaire of tuberculosis patients at Ibrahim Adjiand Gumuruh primary health care during March - August 2018. Result: Based on MMAS-8 questionnaire filled out by 75 patients, there was 69% of high adherence, 15% moderate,  and 16% has low adherence in taking ATD. Of the 6 characteristic factors (i.e., age, sex, occupation, income, education and length of treatment), only gender (p0.01) and occupation (p0.03) factors that influence the patient adherence significantly. Based on MMAS-8 and WHOQOL-BREF questionnaire analyses, there is only psychological health aspect (domain two) that have a significant (p = 0.01) correlated with patient adherence. Conclusion: Based on the results,the psychological health of tuberculosis patients play an important role in patient adherence.

Edukasi Penggunaan Obat Antidiabetes di Bulan Ramadhan pada Masyarakat Desa Buata Kecamatan Botupingge

Permasalahan utama pasien Diabetes Melitus (DM) adalah kepatuhan dalam minum obat dalam jangka Panjang. Pasien diabetes melitus yang mendapat terapi obat antidiabetes oral yang dapat menjalankan ibadah puasa di bulan Ramadhan harus mengikuti aturan baru minum obat, sehingga perlu diberikan informasi mengenai aturan minum obat yang tepat. Pemberian informasi melalui penyebaran brosur merupakan salah satu cara yang paling efektif untuk memperkenalkan aturan pemberian obat yang benar. Kegiatan tersebut berlokasi di Desa Buata, Kecamatan Botupingge, Kabupaten Bone Bolango. Hasil dari kegiatan ini, penderita diabetes melitus lebih siap menghadapi Ramadhan dengan aturan baru minum obat anti diabetes

Pelatihan Pembuatan Tepung Kulit Pepaya sebagai Bahan Dasar Nuget untuk Mencegah Stunting di Desa Huntu Selatan, Kabupaten Bone Bolango

Data stunting di Provinsi Gorontalo berturut-turut mengalami penurunan dari tahun 2018, 32,5% menjadi 29,0% pada tahun 2021, namun masalah stunting masih menjadi persoalan serius di Gorontalo. Desa Huntu Selatan yang berlokasi di Kabupaten Bone Bolango merupakan desa yang berdekatan dengan ibu kota provinsi, walaupun demikian pada tahun 2022 tercatat ada 6 orang balita yang menderita stunting. Pencegahan stunting dapat dilakukan dengan melengkapi nutrisi sejak bayi berada dalam kandungan ibunya, selama proses menyusui hingga masa MPASI pada bayi. Salah satu sumber makanan dengan kandungan gizi yang diperlukan terdapat pada kulit buah pepaya yang banyak ditanam sebagai komoditi lokal di Desa Huntu Selatan. Pemanfaatan buah pepaya menghasilkan limbah kulit pepaya yang terbuang sehingga perlunya suatu pelatihan dalam pengolahan limbah kulit pepaya tersebut. Limbah kulit pepaya dapat diolah menjadi tepung yang dapat digunakan sebagai alternatif tepung terigu. Tepung kulit papaya yang dihasilkan kemudian digunakan sebagai bahan dasar pembuatan nuget untuk meningkatkan cita rasa dan tekstur dari olahan nuget

Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap Di Rumah Sakit

Off-label drugs can be interpreted as drugs that are used not in accordance with drug information, distribution permits and sales licenses from the Marketing Authorization (MA) related to indications, age, dosage, route of administration and contraindications. The use of off-label drugs in children occurs because of incomplete data on pharmacokinetics, pharmacodynamics and side effect of a drug. It is because clinical research in children is quite difficult and not in accordance with research ethics and morals, so it has the potential to cause errors in treatment and unwanted drug reactions. This study aims to describe the use of off-label drugs in hospitalized pediatric patients at RSUD of Dr. M.M Dunda Limboto, Gorontalo District, Gorontalo Province. This is an  observational study using cross sectional design and retrospective data collection. The sampling technique applies a purposive sampling technique with a total of 155 patients who meet the inclusion criteria during the January-June 2020 period. The finding shows that from 155 patient medical records, there are 172 (16,51%) off-label drug used with a total of 1042 drugs. The off-label drugs used in the indication category are 64,53%, the off-label drugs used in dose category are 17,44%, the off-label drugs used in age category are 14,53%, the off-label drugs used in route of administration category are 3,49% and the off-label drugs used in contraindications category are not found. The are the most off-label drugs used in each category, including domperidone (off-label in indications and dose), rhinofed (off-label in age) and salbutamol (off-label in route of administration)

Penetapan kadar Nipagin (Methyl Paraben) pada body lotion yang beredar di Kota Gorontalo secara Spektrofotometri UV-Vis

Body lotion is a skincare cosmetics products that usually contain preservatives as inhibitors of bacteria and fungi growth. According to the Food and Drug Supervisory Agency of Indonesian Republic, 2011: HK.03.1.23.08.11.07517, in which the preservative levels of nipagin (methyl paraben) in a body lotion must be 0.4%, Preservative level over 0.4% may result in skin irritation and allergic reactions. The purpose of this study was to determine the nipagin’s essence and levels in body lotions sold in Gorontalo City. Nipagin’s identification was carried out with a qualitative analysis using Thin Layer Chromatography and color change using 2% of deniges reactor and sodium nitrite, while the quantitative analysis was carried out with spectrophotometry UV-Vis at 258 nm wavelength that was previously extracted with 96% of ethanol solvent. The results of the qualitative study show that four (A, D, E, and F) out of six samples of body lotions: A, B, C, D, E, and F contained preservatives. Quantitatively, the levels of nipagin) on the four samples are sequentially shown as follows: by A:0.38%, D:0.04%, E:0.14%, F:0.14%. All in all, the samples are entirely eligible according to the Regulotions of the National Agency of Drug and Food of Indonesian Republic 2011: HK.03.1.23.08.11.07517

Gambaran Penggunaan Obat Antipsikotik pada Pasien Skizofrenia di Puskesmas Kota Gorontalo

Schizophrenia is one of the most common forms of psychotic mental disorder, with the main symptoms being the absence of self-understanding (insight) and the inability to assess reality (reality testing ability is disturbed). This study aimed to determine the description of the antipsychotic drug's usage, including the drug classes, types, doses, and medication rules in schizophrenia patients at the Kota Selatan Public Health Center, Gorontalo City. This observational study used secondary data and was conducted retrospectively. Further, data obtained from the medical records of 25 schizophrenia patients were analyzed univariately. The results disclosed that schizophrenia was more experienced by men (60%), more prevalent in the age range of 36-45 years (52%), and unmarried (48%)The most widely used antipsychotic drugs were atypical groups (72%). The most widely used type of drug was Risperidone 2 mg with a rule of use of 2 x 1 (39%) and 1 x 1 (9%). Clozapine, 25 mg. with a rule of 2 x 1 was 14%, and 1 x 1 was 9%. Meanwhile, the had 28% consisting typical group only of chlorpromazine 25 mg with tule of use of 1x 1 (12%), haloperidol with a dose of 1.5 mg with a rule of use of 2 sikzonoate 25 mg/ml with 1 x 1 was 5%

Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.)

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics

Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim

God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations