Learning with Biased Complementary Labels

In this paper, we study the classification problem in which we have access to easily obtainable surrogate for true labels, namely complementary labels, which specify classes that observations do \textbf{not} belong to. Let $Y$ and $\bar{Y}$ be the true and complementary labels, respectively. We first model the annotation of complementary labels via transition probabilities $P(\bar{Y}=i|Y=j), i\neq j\in\{1,\cdots,c\}$, where $c$ is the number of classes. Previous methods implicitly assume that $P(\bar{Y}=i|Y=j), \forall i\neq j$, are identical, which is not true in practice because humans are biased toward their own experience. For example, as shown in Figure 1, if an annotator is more familiar with monkeys than prairie dogs when providing complementary labels for meerkats, she is more likely to employ "monkey" as a complementary label. We therefore reason that the transition probabilities will be different. In this paper, we propose a framework that contributes three main innovations to learning with \textbf{biased} complementary labels: (1) It estimates transition probabilities with no bias. (2) It provides a general method to modify traditional loss functions and extends standard deep neural network classifiers to learn with biased complementary labels. (3) It theoretically ensures that the classifier learned with complementary labels converges to the optimal one learned with true labels. Comprehensive experiments on several benchmark datasets validate the superiority of our method to current state-of-the-art methods.Comment: ECCV 2018 Ora

18F-FDG-PET-CT imaging findings of recurrent intracranial haemangiopericytoma with distant metastases

A 42-year-old woman presented with local recurrence and distant lung and liver metastases 7 years after resection of a primary intracranial haemangiopericytoma. Whole-body 18F-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET)-CT scan showed no increased uptake in local recurrence or distant metastases except for a focus of increased FDG uptake within a hepatic metastasis. The hypermetabolic area correlated with an intratumoral hypoenhancing area on the CT scan. PET-CT scan may be useful to allow further understanding of the tumour. © 2010 The British Institute of Radiology.link_to_subscribed_fulltex

High-resolution imaging of two bipolar proto-planetary nebulae

Sub-arcsecond resolution V and I images have been obtained for two proto-planetary nebulae. Both are found to show a definite bipolar morphology. A circumstellar disk is clearly seen in the V - I color image, suggesting that the bipolar lobes are due to starlight scattered into the polar openings. This indicates that bipolar morphologies develop early in the evolution of planetary nebulae, even before the onset of photoionization. © 1996. The American Astronomical Society. All rights reserved.published_or_final_versio

Fully Automatic and Real-Time Catheter Segmentation in X-Ray Fluoroscopy

Augmenting X-ray imaging with 3D roadmap to improve guidance is a common strategy. Such approaches benefit from automated analysis of the X-ray images, such as the automatic detection and tracking of instruments. In this paper, we propose a real-time method to segment the catheter and guidewire in 2D X-ray fluoroscopic sequences. The method is based on deep convolutional neural networks. The network takes as input the current image and the three previous ones, and segments the catheter and guidewire in the current image. Subsequently, a centerline model of the catheter is constructed from the segmented image. A small set of annotated data combined with data augmentation is used to train the network. We trained the method on images from 182 X-ray sequences from 23 different interventions. On a testing set with images of 55 X-ray sequences from 5 other interventions, a median centerline distance error of 0.2 mm and a median tip distance error of 0.9 mm was obtained. The segmentation of the instruments in 2D X-ray sequences is performed in a real-time fully-automatic manner.Comment: Accepted to MICCAI 201

Digit-only sauropod pes trackways from China - evidence of swimming or a preservational phenomenon?

For more than 70 years unusual sauropod trackways have played a pivotal role in debates about the swimming ability of sauropods. Most claims that sauropods could swim have been based on manus-only or manus-dominated trackways. However none of these incomplete trackways has been entirely convincing, and most have proved to be taphonomic artifacts, either undertracks or the result of differential depth of penetration of manus and pes tracks, but otherwise showed the typical pattern of normal walking trackways. Here we report an assemblage of unusual sauropod tracks from the Lower Cretaceous Hekou Group of Gansu Province, northern China, characterized by the preservation of only the pes claw traces, that we interpret as having been left by walking, not buoyant or swimming, individuals. They are interpreted as the result of animals moving on a soft mud-silt substrate, projecting their claws deeply to register their traces on an underlying sand layer where they gained more grip during progression. Other sauropod walking trackways on the same surface with both pes and manus traces preserved, were probably left earlier on relatively firm substrates that predated the deposition of soft mud and silt . Presently, there is no convincing evidence of swimming sauropods from their trackways, which is not to say that sauropods did not swim at all

STEM materials: a new frontier for an intelligent sustainable world

Materials are addressed as possible enablers for solutions to many global societal challenges. A foresight exercise has been conducted to identify research paths to design, with a new approach, a generation of materials which can provide multi-functionalities. These material systems have been named ???stem???, in analogy to living cells where a base of primitive units can be designed and assembled for self-reacting to external inputs. These materials will embed a concept of ???internet in things???, where their processing capacity will enable the systems to interact with the environment and express diverse functionalities. Stem materials do not exist yet, but many clues from diferent theoretical and experimental results suggest they can be developed, and because living organisms exist. This article aims at launching this new approach and promoting the structuring of a multi-disciplinary community to fll the research gaps

Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT

Purpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.published_or_final_versionSpringer Open Choice, 21 Feb 201

Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor

Erythropoietin (EPO) has protective effects in neurodegenerative and neuroinflammatory diseases, including in animal models of multiple sclerosis, where EPO decreases disease severity. EPO also promotes neurogenesis and is protective in models of toxic demyelination. In this study, we asked whether EPO could promote neurorepair by also inducing remyelination. In addition, we investigated whether the effect of EPO could be mediated by the classical erythropoietic EPO receptor (EPOR), since it is still questioned if EPOR is functional in non-hematopoietic cells. Using CG4 cells, a line of rat oligodendrocyte precursor cells, we found that EPO increases the expression of myelin genes (myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP)). EPO had no effect in wild-type CG4 cells, which do not express EPOR, whereas it increased MOG and MBP expression in cells engineered to overexpress EPOR (CG4-EPOR). This was reflected in a marked increase in MOG protein levels, as detected by western blot. In these cells, EPO induced by 10-fold the early growth response gene 2 (Egr2), which is required for peripheral myelination. However, Egr2 silencing with a siRNA did not reverse the effect of EPO, indicating that EPO acts through other pathways. In conclusion, EPO induces the expression of myelin genes in oligodendrocytes and this effect requires the presence of EPOR. This study demonstrates that EPOR can mediate neuroreparative effects

Radiation dose and cancer risk in retrospectively and prospectively ECG-gated coronary angiography using 64-slice multidetector CT

This study aimed to estimate the radiation dose and cancer risk to adults in England, the USA and Hong Kong associated with retrospectively and prospectively electrocardiogram (ECG)-gated coronary computed tomography angiography (CTA) using currently practised protocols in Hong Kong. The doses were simulated using the ImPACT spreadsheet. For retrospectively ECG-gated CTAwith pitches of 0.2, 0.22 and 0.24, the effective doseswere 27.7, 23.6 and 20.7 mSv, respectively, formales and 23.6, 20.0 and 18.8 mSv, respectively, for females. For prospectively ECG-gated CTA, the effective dose was 3.7 mSv for both males and females. A table of lifetime attributable risks (LAR) of cancer incidence was set up for the English population for the purpose of estimating cancer risk induced by low-dose radiation exposure, as previously reported for US and Hong Kong populations. From the tables, the LAR of cancer incidence for a representative 50-year-old subject was calculated for retrospectively ECG-gated CTA to be 0.112% and 0.227% for English males and females, respectively, 0.103%and 0.228%for USmales and females, respectively, and was comparatively higher at 0.137% and 0.370% for Hong Kong males and females, respectively; for prospectively ECG-gated CTA, the corresponding values were calculated to be 0.014% and 0.035% for English males and females, respectively, and 0.013%and 0.036%for US males and females, respectively, and againwere higher at 0.017%and 0.060% for Hong Kongmales and females, respectively. Our study shows that prospectively ECG-gated CTA reduces radiation dose and cancer risks by up to 87% compared with retrospectively ECG-gated CTA. © 2010 The British Institute of Radiology.link_to_OA_fulltex