Arousing and attracting millennial talents

Arousing and attracting millennial talents is a research paper that will investigate the shift of generational dominance between the baby boomers and the Millennials. This generational shift comes with serious implications for the large and the start-up organizations. This shift coincides with an important shake-up in our current economy situation. The consumer becomes less faithful and ever more demanding, encouraging the burgeoning of start-ups that tries to fill the gaps in the market. This trend contains important repercussions for large organizations that do not innovate at such a fast pace. These two main factors are the reason why the research focuses on topics of “Millennials” and “change”. Based on these topics a review of the literature showed that people and their awareness and will to change are essential for the prosperity of the different types of companies. This research focuses on the addition of the young Millennial talent in order for the change to happen within the company. These Millennial talents have proven to be excellent change agents and can be the outside motivation for the companies to innovate

Nitrate concentration in wetlands: assessing the contribution of deeper groundwater from anions

International audienceDenitrification in wetlands is useful for removing nitrate from the surface water, although it can be difficult to assess wetland functioning particularly where it overlies a hard-rock aquifer whose fractures and joints form pathways that mix waters with different chemical composition. The variability of NO3 concentrations in such waters, which partly transit through wetlands, can obscure the effect of denitrification. To address this question, we monitored groundwater chemistry at different depths on three pilot sites overlying (mica)schist aquifers with almost no NO3 contamination at depth, probably due to denitrification. The spatial variability of NO3 concentrations, both along the flowpath and with depth, is related in each site to at least one of the following factors: (1) upward flux of deeper NO3-free groundwater; (2) in situ heterotrophic denitrification; (3) application of different types of fertilizer and other amendments. These factors are efficiently discriminated by the monitoring of just three, easily affordable, parameters: NO3, SO4 and Cl

Cooperation between SSTC NRS and the EU in the area of nuclear safety

The paper first briefly outlines the main characteristics of the EU assistance programs aimed to enhance nuclear safety in the Beneficiary countries. Then EU assistance provided to the Ukrainian regulator (SNRIU) is detailed, with specific emphasis on projects enhancing the capabilities of SSTC NRS as technical support organisation (TSO) to SNRIU, including training and tutoring (T&T) activities. The changing role of SSTC NRS in the cooperation activities is described as well. The broad range of cooperation is then illustrated by some selected projects focusing on various technical areas (e.g. severe accident management and mitigation, radioactive waste and spent fuel management, NPP service time extension, plant performance monitoring and operating experience feedback). Finally, the paper briefly discusses the future perspectives of the nuclear safety cooperation between the EU and Ukraine.JRC.G.I.4-Nuclear Reactor Safety and Emergency Preparednes

Localization of primary pancreatic neuroendocrine tumors by endoscopic ultrasonography and somatostatin receptor scintigraphy

Localization of primary pancreatic neuroendocrine tumors by endoscopic ultrasonography and somatostatin receptor scintigraph

Comparative thrombolytic properties of tissue-type plasminogen activator (t-PA), single-chain urokinase-type plasminogen activator (u-PA) and K1K2Pu(a t-PA/u-PA Chimera) in a combined arterial and venous thrombosis model in the dog

AbstractThe chimeric molecule K1K2Pu, comprising the two kringle domains (K1and K2) of tissue-type plasminogen activator (t-PA) and the COOH-terminal region with the serine protease domain (Pu) of urokinase-type plasminogen activator (u-PA), was previously shown to have a 5- to 10-fold reduced clearance rate with maintained specific thrombolytic activity, resulting in an increased thrombolytic potency in animal models of venous and arterial thrombosis.To document the thrombolytic potential of K1K2Pu, the thrombolytic potency and fibrin specificity were studied in a combined platelet-rich arterial eversion graft thrombosis and venous whole blood clot model in heparinized dogs (100 U/kg bolus and 50 U/kg per h infusion). Dose-response effects of bolus injections of K1K2Pu(0.032 to 0.25 mg/kg) were compared with those of recombinant t-PA (rt-PA) and of recombinant single chain u-PA (rscu-PA) (0.25 to 1.0 mg/kg each) in groups of five or six dogs, each given hcparin with or without the thromboxane synthase inhibitor/prostaglandin endoperoxide receptor antagonist ridogrel. Heparin and ridogrel in the absence of a thrombolytic agent did not produce arterial reflow or venous clot lysis in five dogs. Addition of K1K2Pu, rt-PA or rscu-PA resulted in a dose-dependent induction of arterial reflow and of venous clot lysis in the absence of systemic fibrinolytic activation and fibrinogen breakdown.Consistent arterial reflow required 0.063 mg/kg of K1K2Puand 0.5 mg/kg of rt-PA or of rscu-PA. The thrombolytic potency for venous clot lysis, expressed as percent lysis per mg compound administered per kg body weight, was (mean ± SEM) 750 ± 160 for K1K2Pu, 68 ± 17 for rscu-PA (p < 0.001 vs. K1K2Pu) and 110 ± 29 for rt-PA (p < 0.001 vs. K1K2Pu). The plasma clearance rates were significantly lower for K1K2Puthan for rscu-PA and rt-PA. In the absence of ridogrel, arterial reflow was significantly slower and was followed by cyclic reocclusion and reflow; however, venous clot lysis was unaffected. Template bleeding times were not significantly altered in the absence but were markedly prolonged in the presence of ridogrel.These results confirm and establish that, when given as a bolus injection, K1K2Puhas an approximately 10-fold higher thrombolytic potency for arterial and venous thrombolysis than does rt-PA or rscu-PA. Thrombolysis with K1K2Puis obtained in the absence of systemic fibrinolytic activation and fibrinogen breakdown. These properties suggest that K1K2Puoffers potential for thrombolytic therapy by bolus administration in patients with thromboembolic disease