Drug Delivery System Involving Interaction Between Protein or Polypeptide and Hydrophobic Biodegradable Polymer

A drug delivery system for controlled release of a protein or polypeptide comprising a hydrophobic biodegradable polymer and a protein or polypeptide. A physical interaction is present between the polymer and the protein or polypeptide, thus, allowing protection and controlled release of the protein or polypeptide in-vivo. The drug delivery system may be prepared by a polymer precipitation technique or a microsphere technique

Mechanical properties of turbine blade alloys in hydrogen at elevated temperatures

The mechanical properties of single crystal turbine blade alloys in a gaseous hydrogen environment were determined. These alloys are proposed for use in space propulsion systems in pure or partial high pressure hydrogen environments at elevated temperatures. Mechanical property tests included: tensile, creep, low fatigue (LCF), and crack growth. Specimens were in both transverse and longitudinal directions relative to the casting solidification direction. Testing was conducted on solid specimens exposed to externally pressurized environments of gaseous hydrogen and hydrogen-enriched steam

Preparation of Biodegradable Microspheres Useful as Carriers for Macromolecules

A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein

Biodegradable Microspheres as a Carrier for Macromolecules

A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein

Perspectives on Iowa Coal

https://lib.dr.iastate.edu/emrri_reports/1000/thumbnail.jp

Testing the Integrity of Liquid Containing Hermetically Sealed Containers by the Use of Radioactive Markers

A method for detecting leaky ampules filled with a liquid such as a parenteral solution. The ampules to be tested are immersed in a solution containing a short-lived radionuclide, and a pressure differential is imposed between the solution containing the radionuclide and the parenteral solution or other liquid contained in the ampules. The ampules are then removed from solution, decontaminated to remove any solution adhering to the outer surface and pores thereof, dried, and finally examined for electromagnetic radiation, preferably gamma radiation, emanating from the interior of the ampules which would indicate a leaky condition thereof